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  4. Recombinant Mouse Latent-transforming growth factor beta-binding protein 3 (Ltbp3), partial

Recombinant Mouse Latent-transforming growth factor beta-binding protein 3 (Ltbp3), partial

  • 中文名稱：
    小鼠Ltbp3重組蛋白
  • 貨號：
    CSB-YP730754MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ltbp3重組蛋白
  • 貨號：
    CSB-EP730754MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ltbp3重組蛋白
  • 貨號：
    CSB-EP730754MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ltbp3重組蛋白
  • 貨號：
    CSB-BP730754MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ltbp3重組蛋白
  • 貨號：
    CSB-MP730754MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ltbp3
  • Uniprot No.：
  • 別名：
    Ltbp3Latent-transforming growth factor beta-binding protein 3; LTBP-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
  • 基因功能參考文獻：
    1. Marfan syndrome mice lacking LTBP-3 have improved survival, essentially no aneurysms, reduced disruption and fragmentation of medial elastic fibers, and decreased Smad2/3 and Erk1/2 activation in their aortas. PMID: 26494287
    2. These data indicate that LTBP-3 and -4 perform partially overlapping functions only in the lungs. PMID: 20945348
    3. Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability PMID: 11790802
    4. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta propeptide. PMID: 12062452
    5. Disruption of Ltbp-3 gene by homologous recombination in mice yields mutant animals displaying multiple skeletal abnormalities and retarded growth. Severe involution of thymus and spleen and reduction in CD4/CD8 double positive T-cells in thymus. PMID: 12811825
    6. Lack of Ltbp-3 results in decreased levels of TGF-beta in bone and cartilage, which leads to compromised osteoclast function and decreased bone turnover. PMID: 15878314
    7. Loss of Ltbp-3 is associated with lung alveolar septation and developmental emphysema. PMID: 16049328

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  • 亞細胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    LTBP family
  • 數據庫鏈接：


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