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  4. Recombinant Mouse Laminin subunit alpha-1 (Lama1), partial

Recombinant Mouse Laminin subunit alpha-1 (Lama1), partial

  • 中文名稱：
    小鼠Lama1重組蛋白
  • 貨號：
    CSB-YP012725MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Lama1重組蛋白
  • 貨號：
    CSB-EP012725MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Lama1重組蛋白
  • 貨號：
    CSB-EP012725MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Lama1重組蛋白
  • 貨號：
    CSB-BP012725MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Lama1重組蛋白
  • 貨號：
    CSB-MP012725MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Lama1; Lama; Lama-1; Laminin subunit alpha-1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻：
    1. laminin-1 does not have a positive effect on ENCC migration in HD mice on E12.5, in contrast to the phenomenon seen in normal mice gut specimens, where laminin-1 promotes ENCC migration during the same period. PMID: 29018955
    2. Altered LAMA1 expression in the aganglionic region may contribute to impaired ENCC migration, resulting in HD. These data could help in understanding the pathophysiologic interactions between LAMA1 and ENCC migration PMID: 28983681
    3. Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture. PMID: 27964993
    4. Laminin differentially regulates the stemness of type I and type II pericytes. PMID: 28173861
    5. Laminin regulates PDGFRbeta cell differentiation, fate determination, cell stemness and muscle development via gpihbp1. PMID: 27138650
    6. while MMP-9 is not essential for hypoxic-induced cerebral angiogenesis, it plays an important role in post-hypoxic vascular pruning by degrading laminin and claudin-5 PMID: 25812799
    7. These findings suggest that LAMA1 plays a critical role in kidney function and kidney aging by regulating the mesangial cell population and mesangial matrix deposition through TGF-beta/Smad signaling. PMID: 24720953
    8. Mutations in Lama1 allow developing retinal vessels to enter the vitreous where they anastomose with vessels of the hyaloid system which persist and expand PMID: 21999428
    9. #NAME? PMID: 22270369
    10. Our data show that the absence of Lama1 has an impact on the Bergmann glia scaffold that aberrantly develops. PMID: 22274713
    11. Laminin alpha1 is essential for mouse cerebellar development. PMID: 21983115
    12. Laminin promotes epithelial formation of XEN cells, and up-regulation of visceral endoderm markers. PMID: 22027433
    13. Laminin alpha1 chain is not responsible for muscle disease in the mdx mouse model for Duchenne muscular dystrophy PMID: 21435454
    14. The results show that laminin alpha1LG domains and consequently their receptors have disparate functions in the neuromuscular system PMID: 20657839
    15. we analyze the lifespan of laminin alpha2 chain-deficient mice with transgenic overexpression of laminin alpha1 chain PMID: 20544910
    16. This first report of viable Lama1 mouse mutants emphasizes the importance of this gene in retinal development, and data suggest that hypomorphic mutations in human LAMA1 could lead to retinal disease. PMID: 20048158
    17. Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression. PMID: 11827968
    18. Expression and distribution of laminin alpha1 in embryonic and adult mouse tissues PMID: 11969289
    19. mouse laminin alpha 1 gene has an upstream enhancer that defines its expression in parietal endoderm cells PMID: 12519763
    20. Data suggest that surface-exposed, conserved residues of the laminin gamma1 chain interact with the N-terminal domain of agrin via hydrophobic and ionic interactions. PMID: 12554653
    21. The absence of a alpha3(IV), alpha4(IV), alpha5(IV) network may stimulate reexpression of laminin-1 by Alport mouse endothelial cells and podocytes PMID: 12631063
    22. the first characterization of the Lama1 promoter; identification of a regulatory elements that may account for the expression pattern of the endogenous protein in the mouse intestine PMID: 14634001
    23. Mouse embryonic stem cells seeded on laminin formed hemispheric epithelial structures whose outermost layer terminally differentiated to an epithelium that resembled the visceral endoderm. PMID: 15452149
    24. Deletion of binding domains impair fetal development by preventing conversion of stem cells to polarized epithelium. PMID: 15668394
    25. The transient expression of laminin alpha1 may promote formation of sinusoids after partial hepatectomy. PMID: 15777791
    26. Grb2-binding to syntrophin is increased by addition of either laminin-1 or isolated laminin alpha1 globular domain modules LG4-5. LG4-5 sequences are the region of laminin responsible for signaling. Alpha-dystroglycan is the laminin-signaling receptor. PMID: 16475793
    27. suggest that LNalpha1 chain in part ameliorates the development of LNalpha2 chain deficient muscular dystrophy by retaining the binding sites for integrin alpha7Bbeta1D and alpha-dystroglycan, respectively PMID: 16504180
    28. analysis of structure and activities reveal differences in laminin G-like domain interactions that should enable dissection of biological roles of different laminin ligands PMID: 17307732
    29. Upregulation of Lama5 transcription and concentration of laminin alpha1 and alpha5 within Alport glomerular basement membrane thickenings contribute to abnormal permeabilities. PMID: 17699809
    30. define sites for the interaction of acetylcholinesterase and laminin and suggest that the interaction plays a role in cell adhesion PMID: 18215127
    31. The nonsulfated HNK-1 epitope on laminin-1 may regulate its binding and play a role in maintenance of the proper structure in the kidney basal lamina. PMID: 18263654
    32. Data examined expression of laminin-1, perlecan, tenascin-C, and CSPGs and found a coordinated pattern of expression of these cues in the olfactory pathway. These appear to restrict axons to the pathway while promoting axon outgrowth within. PMID: 18570250
    33. Our data suggest that doxycycline may provide a neuroprotection against global cerebral ischemia since it reduces perineuronal laminin degradation by inhibiting MMP-9 activity. PMID: 19200854
    34. Data suggest that laminin alpha1 domains LG4-5 provide an autocrine signal necessary for the complete differentiation of a functional visceral endoderm and vital signals for the polarization of the epiblast. PMID: 19657675
    35. Recovery of Lama1 expression or addition of exogenous laminin-111 to Shh(-/-);Gli3(-/-) embryos restores the myotomal basement membrane, demonstrating that laminin-111 is necessary and sufficient to initiate assembly of the myotomal basement membrane. PMID: 19783738
    36. Residues 'sinnnrwhsiyitrfgnmgs' promote adhesion in a heparin-sensitive but integrin-independent manner and binds approx. 155 kDa and 180 kDa cell surface proteins. PMID: 9124607
    37. Adhesion site formed by 'sinnnrwhsiyitrfgnmgs' is involved in formation of lung 'alveoli' in vitro. PMID: 8132708

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  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 數據庫鏈接：


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