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  4. Recombinant Mouse Kv channel-interacting protein 1 (Kcnip1)

Recombinant Mouse Kv channel-interacting protein 1 (Kcnip1)

  • 中文名稱：
    小鼠Kcnip1重組蛋白
  • 貨號：
    CSB-YP881316MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kcnip1重組蛋白
  • 貨號：
    CSB-EP881316MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kcnip1重組蛋白
  • 貨號：
    CSB-EP881316MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kcnip1重組蛋白
  • 貨號：
    CSB-BP881316MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kcnip1重組蛋白
  • 貨號：
    CSB-MP881316MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnip1
  • Uniprot No.：
  • 別名：
    Kcnip1; Kchip1; Kv channel-interacting protein 1; KChIP1; A-type potassium channel modulatory protein 1; Potassium channel-interacting protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-227
  • 氨基酸序列
    MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL EQLEAQTNFT KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST YAHYLFNAFD TTQTGSVKFE DFVTALSILL RGTVHEKLRW TFNLYDINKD GYINKEEMMD IVKAIYDMMG KYTYPVLKED TPRQHVDVFF QKMDKNKDGI VTLDEFLESC QEDDNIMRSL QLFQNVM
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents. In vitro, modulates KCND1/Kv4.1 currents. Increases the presence of KCND2 at the cell surface.
  • 基因功能參考文獻：
    1. KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission. PMID: 20678225
    2. Differential expression of KCh1P1 splice variants can shape the function of Kv4.2 channels involved in protection against back propagating action potentials in dendritic spines. PMID: 14572458
    3. KChIP1 was expressed in a subpopulation of neurons widely distributed in brain and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei. PMID: 15363885
    4. aromatic cluster in exon1b modulates the transitions towards and from the closed inactivated states and the steady state distribution over the respective states PMID: 17640927
    5. KChIP1 deletion showed increased susceptibility to anti-GABAergic convulsive drug pentylenetetrazole-induced seizure, indicating that KChIP1 might play pivotal roles in the GABAergic inhibitory system. PMID: 19352544

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, dendrite.
  • 蛋白家族：
    Recoverin family
  • 組織特異性：
    Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.
  • 數據庫鏈接：


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