在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Interleukin-23 receptor (Il23r), partial

Recombinant Mouse Interleukin-23 receptor (Il23r), partial

  • 中文名稱：
    小鼠Il23r重組蛋白
  • 貨號：
    CSB-YP814324MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Il23r重組蛋白
  • 貨號：
    CSB-EP814324MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Il23r重組蛋白
  • 貨號：
    CSB-EP814324MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Il23r重組蛋白
  • 貨號：
    CSB-BP814324MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Il23r重組蛋白
  • 貨號：
    CSB-MP814324MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Il23rInterleukin-23 receptor; IL-23 receptor; IL-23R
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
  • 基因功能參考文獻：
    1. Results suggest that the use of vectors carrying Soluble Interleukin-23 Receptor (sIL-23R) to block the interleukin-23/IL-23R interaction may be a new therapeutic strategy for the treatment of multiple sclerosis. PMID: 28593439
    2. RBPJ binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 production in Th17 cells. PMID: 27346359
    3. Epithelial IL-23R signaling enables protective IL-22 responses in experimental colitis. PMID: 27524624
    4. Study highlights the importance of IL-23R expression level and the instability of Foxp3+ regulatory T cells in the development of inflammatory bowel diseases. PMID: 27498708
    5. Differential splicing generates antagonistic soluble IL-23R (sIL-23R) variants, which might limit IL-23-mediated immune responses. Here, ectodomain shedding of IL-23R was identified as an alternative pathway for the generation of sIL-23R. PMID: 26961870
    6. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. PMID: 26242299
    7. IL-23 plus T-cell receptor signalling results in significant upregulation of IL-23 receptor expressed predominantly on CD4(hi)CD8(hi)CD3(+)alphabetaTCR(+) thymocytes, and leads to RORgammat-dependent apoptosis. PMID: 25001511
    8. Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota. PMID: 25201978
    9. Characterization of potent IL-23R small-peptide modulator, 2305 (teeeqqly), that decreases inflammatory response. PMID: 25354400
    10. Although they share a common subunit, IL-23 and IL-12 receptors are not expressed on the same cell populations PMID: 24586521
    11. IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. PMID: 23715173
    12. the balance between the enhancing and inhibitory effects of gamma-delta T cells is regulated by their level of IL-23R expression. PMID: 23797670
    13. Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor. PMID: 23673666
    14. study indicates the importance of IL-23 pathway in Th17 development and the negative regulation of Th17 development by IL23R-CHR PMID: 23029144
    15. The IL-23 receptor is necessary for lymphoid hyperplasia, production of pathogenic autoantibodies, and infiltration of kidneys by IL-17-expressing cells in lupus-prone mice. PMID: 20308633
    16. suppression of T-bet ameliorates EAE by limiting the differentiation of autoreactive Th1 cells, as well as inhibiting pathogenic Th17 cells via regulation of IL-23R. PMID: 17237380
    17. IL-23R deficiency inhibited terminal differentiation of interleukin 17-producing effector T helper cells. PMID: 19182808
    18. These results suggest that the induction of IL-23R and Th17 differentiation by IL-6 and IL-23 is mediated through endogenously produced TGF-beta. PMID: 19501566

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 組織特異性：
    Expressed by Th1, Th2 and dendritic cells.
  • 數據庫鏈接：


主站蜘蛛池模板： 又色又爽又黄的gif动态图| 国产又大又黑又粗免费视频| 超碰97久久国产精品牛牛| 国产欧美久久一区二区| 丰满少妇被猛烈进入| 99在线 | 亚洲| 国产一卡二卡四卡无卡免费| 日韩人妻无码精品久久久不卡| 国产亚洲精品久久久久秋霞| 国产精品人妻久久毛片| 少妇爽到呻吟的视频| 亚洲丁香婷婷久久一区二区| 国产熟睡乱子伦视频| 国产精品人妻久久毛片| 亚洲精品国产一二三无码av| 欧美日韩精品| 无码中文av有码中文av| 亚洲精品国产精品无码国模| 国产在线高清视频无码| 宅女午夜福利免费视频| 亚洲国产精品特色大片观看完整版 | 任你躁久久精品6| 亚洲精品图片区小说区| 久久人妻av一区二区软件| 丰满少妇被猛烈进入| 久久国产精品2020免费| 国产肉体xxxx裸体784大胆| 欧美午夜精品一区二区三区电影 | 欧洲精品va无码一区二区三区| 亚洲一卡二卡三卡四卡无卡麻豆| 女人大荫蒂毛茸茸视频| 国产精品黄页免费高清在线观看 | 老司机深夜18禁污污网站| 国产在线乱子伦一区二区| 性视频播放免费视频| 久章草在线精品视频免费观看| 国产精品视频观看裸模| 国产成人综合在线视频| av人摸人人人澡人人超碰小说| 日韩69永久免费视频| 国产偷窥熟女高潮精品视频|