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  4. Recombinant Mouse Interferon regulatory factor 6 (Irf6)

Recombinant Mouse Interferon regulatory factor 6 (Irf6)

  • 中文名稱：
    小鼠Irf6重組蛋白
  • 貨號：
    CSB-YP011821MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Irf6重組蛋白
  • 貨號：
    CSB-EP011821MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Irf6重組蛋白
  • 貨號：
    CSB-EP011821MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Irf6重組蛋白
  • 貨號：
    CSB-BP011821MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Irf6重組蛋白
  • 貨號：
    CSB-MP011821MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Irf6; Interferon regulatory factor 6; IRF-6
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-467
  • 氨基酸序列
    MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ EEENTIFKAW AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT KEVPMNPVKI YQVCDIPQTQ GSVINPGSTG SAPWDEKDND VDEDEEEDEL EQSQHHVPIQ DTFPFLNING SPMAPASVGN CSVGNCSPES VWPKTEPLEM EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT MTVSNPQGCR LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR GLILEVSGHA IYAIRLCQCK VYWSGPCAPS LAAPNLIERQ KKVKLFCLET FLSELIAHQK GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR MIYEMFSGDF TRSFDSGSVR LQISTPDIKD NIVAQLKQLY RILQTQESWQ PMQPAPSMQL PQALPAQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription.
  • 基因功能參考文獻：
    1. we identified IRF6 as a novel PPARgamma co-suppressor that serves a key role in suppressing PPARgamma-mediated cerebrovascular endothelial cytoprotection following ischemia. PMID: 28526834
    2. IRF6 expression in basal epithelium partially rescues Irf6 knockout mice PMID: 28643456
    3. Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha and Irf6. PMID: 27302476
    4. IRF6 suppresses PPARgamma through binding IRF recognition sites located upstream of the PPARgamma coding region. Taken together, the results suggest that an IRF6/PPARgamma regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue. PMID: 28645193
    5. These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP and indicate a direct role for the major CLP gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice. PMID: 27927890
    6. role in tooth number, crown and root morphology and amelogenesis PMID: 27369589
    7. that downregulation of interferon regulatory factor 6 affords protection against TNI through Akt-eNOS pathway-mediated antioxidative and anti-inflammatory activity PMID: 27306759
    8. Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro. PMID: 27035130
    9. Data suggest that Irf6 functions through the RhoA pathway to regulate cellular migration. PMID: 24777480
    10. These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting. PMID: 24357509
    11. Irf6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue. PMID: 23451037
    12. Irf6 plays a critical role in regulating epithelial invagination PMID: 22366192
    13. IRF6 and SMAD4 synergistically regulate the fate of the medial edge epithelium (MEE), and TGFbeta-mediated Irf6 activity is responsible for MEE degeneration during palatal fusion in mice. PMID: 23406900
    14. Overexpression of Irf6 in wild-type keratinocytes was insufficient to induce expression of markers of differentiation under growing conditions. PMID: 21918538
    15. Data show that the Irf6(clft1) allele provides the first mouse model for the study of an etiologic IRF6 missense mutation observed in a human VWS family. PMID: 20196077
    16. Plays a role during the fusion events that occur during development of the lip and palate. PMID: 16245336
    17. New role for an IRF family member in epidermal development. PMID: 17041601
    18. IRF6 increases in quiescent, differentiated lobuloalveolar cells of the lactating mammary gland compared to its expression in proliferating ductal & glandular epithelial cells during pregnancy. PMID: 18212048
    19. IRF6 and Jagged2 is essential for controlling palatal adhesion. PMID: 19439425
    20. The results support the hypothesis that IRF6 and Maspin are important for mammary epithelial cell differentiation. PMID: 19527266

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    IRF family
  • 組織特異性：
    High levels of expression along the medial edge of the fusing palate, tooth buds, hair follicles, genitalia and skin.
  • 數據庫鏈接：


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