在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Interferon-induced 35 kDa protein homolog (Ifi35)

  • 中文名稱:
    小鼠Ifi35重組蛋白
  • 貨號:
    CSB-YP887549MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Ifi35重組蛋白
  • 貨號:
    CSB-EP887549MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Ifi35重組蛋白
  • 貨號:
    CSB-BP887549MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Ifi35重組蛋白
  • 貨號:
    CSB-MP887549MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Ifi35
  • Uniprot No.:
  • 別名:
    Ifi35Interferon-induced 35 kDa protein homolog; IFP 35; Ifi-35
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 表達區域:
    1-286
  • 氨基酸序列
    MSVTLQTVLY SLQEEQARLK MRLQELQQLK RERTGSPGAK IPFSVPEVPL VFQGQTKQGR QVPKFVVSNL KVCCPLPEGS ALVTFEDPKV VDRLLQQKEH RVNLEDCRLR VQVQPLELPV VTNIQVSSQP DNHRVLVSGF PAGLRLSEEE LLDKLEIFFG KAKNGGGDVE TREMLQGTVM LGFADEEVAQ HLCQIGQFRV PLDRQQVLLR VSPYVSGEIQ KAEIKFQQAP HSVLVTNIPD VMDAQELHDI LEIHFQKPTR GGGEVEALTV VPSGQQGLAI FTSESS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as a signaling pathway regulator involved in innate immune system response. In response to interferon IFN-alpha, associates in a complex with transcriptional regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation. In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production. In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries. Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion. Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines.
  • 基因功能參考文獻:
    1. High Expression of Ifi35 is associated with exacerbates lung inflammation and H5N1 influenza disease. PMID: 29698474
    2. Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways. PMID: 29038465
  • 亞細胞定位:
    Cytoplasm. Nucleus. Secreted.
  • 蛋白家族:
    NMI family
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲人成电影在线天堂色| 美乳丰满人妻无码视频| 国产精品亚洲а∨怡红院| 国农村精品国产自线拍| 久久精品人妻无码一区二区三区| 天堂av男人在线播放| 影音先锋人妻每日资源站| 丰满少妇被猛烈进av毛片| 亚洲成av人片不卡无码| 久久久天堂国产精品女人| 欧美人与禽zozzo性伦交| 在线播放国产精品三级| 国产韩国精品一区二区三区久久 | 国产专区国产av| 国产精品久久福利网站| 国精品人妻无码一区二区三区蜜柚| 亚洲精品gv天堂无码男同| 性猛交ⅹxxx富婆视频| 亚洲国产高清在线一区二区三区| 国产午夜福利精品一区| 欧美人和黑人牲交网站上线| 国产午夜伦鲁鲁| 日本免费一区二区三区日本| 久久不见久久见免费视频观看| 少妇系列之白嫩人妻| 亚洲一卡2卡三卡四卡精品| 亚洲精品中文字幕久久久久下载| 一本色综合亚洲精品蜜桃冫| 亚洲码国产精品高潮在线| 伊人色综合久久天天网| 伊人婷婷六月狠狠狠去| 老熟妇高潮一区二区三区| av无码久久久久不卡蜜桃| 国产精品高潮呻吟av久久男男| 人妻少妇中文字幕乱码| 在线天堂www在线国语对白| 日韩少妇激情一区二区| 免费观看美女裸体网站| 日韩中文字幕区一区有砖一区| 熟女俱乐部五十路六十路| 日本欧美视频在线观看|