在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Hypermethylated in cancer 1 protein (Hic1)

Recombinant Mouse Hypermethylated in cancer 1 protein (Hic1)

  • 中文名稱：
    小鼠Hic1重組蛋白
  • 貨號：
    CSB-YP870826MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hic1重組蛋白
  • 貨號：
    CSB-EP870826MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hic1重組蛋白
  • 貨號：
    CSB-EP870826MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hic1重組蛋白
  • 貨號：
    CSB-BP870826MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hic1重組蛋白
  • 貨號：
    CSB-MP870826MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hic1
  • Uniprot No.：
  • 別名：
    Hic1Hypermethylated in cancer 1 protein; Hic-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-733
  • 氨基酸序列
    MTFPEADILL KSGECAGQTM LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI IVVQNALFRA HKNVLAASSA YLKSLVVHDN LLNLDHDMVS PAVFRLVLDF IYTGRLTDSV EAAAAAAVAP GAEPSLGAVL AAASYLQIPD LVALCKKRLK RHGKYCHLRG GGSGGGGYAP YGRPGRGLRA ATPVIQACYS SPAGPPPPPA AEPPSGPDAA VNTHCAELYA SGPGPAASLC APERRCSPLC GLDLSKKSPP GSSVPERPLS ERELPPRPDS PPGAGPAVYK EPSLALPPLP PLPFQKLEEA VPTPDPFRGS GGSPGPEPPG RPDGSSLLYR WMKHEPGLGS YGDELVRDRG SPGERLEERG GDPAASPGGP PLGLVPPPRY PGSLDGPGTG ADGDDYKSSS EETGSSEDPS PPGGHLEGYP CPHLAYGEPE SFGDNLYVCI PCGKGFPSSE QLNAHVEAHV EEEEALYGRA EAAEVAAGAA GLGPPFGGGG DKVTGAPGGL GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC GKKFTQRGTM TRHMRSHLGL KPFACDACGM RFTRQYRLTE HMRIHSGEKP YECQVCGGKF AQQRNLISHM KMHAVGGAAG AAGALAGLGG LPGVPGPDGK GKLDFPEGVF AVARLTAEQL SLKQQDKAAA AELLAQTTHF LHDPKVALES LYPLAKFTAE LGLSPDKAAE VLSQGAHLAA GPDSRTIDRF SPT
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. Involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
  • 基因功能參考文獻：
    1. Intestinal innate lymphoid cells express HIC1 in a vitamin A-dependent manner. PMID: 29470558
    2. this study identified a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions PMID: 28327618
    3. HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition. PMID: 28466555
    4. identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb-like proteins. PMID: 22315224
    5. Data show that Hic1 expression is absent in polyps from DH mice, with concomitant increased expression of two transcriptional repression targets of Hic1, Sirt1 and Sox9. PMID: 21297660
    6. A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. PMID: 20154726
    7. mice disrupted in the germ line for only one allele of Hic1 develop many different spontaneous malignant tumors, including a predominance of epithelial cancers in males and lymphomas and sarcomas in females PMID: 12539045
    8. In human osteosarcomas, hypermethylation of HIC1 is frequent only in tumors with p53 mutation PMID: 15488761
    9. Inactivation of HIC1 results in upregulated SIRT1 expression in normal or cancer cells; this deacetylates and inactivates p53, allowing cells to bypass apoptosis and survive DNA damage. PMID: 16269335
    10. For the Hic-1 gene, but not p16, the p53 gene might protect against aberrant methylation. The iNOS gene might not be involved in methylation of the Hic-1 gene, whereas the promoter region of p16 could be prone to methylation in MEFs lacking the iNOS gene. PMID: 18751382

    顯示更多

    收起更多

  • 相關疾病：
    Defects in Hic1 are the cause of perinatal death with serious developmental anomalies, including acrania, exencephaly, cleft palate, omphalocele, craniofacial and limb anomalies.
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family, Hic subfamily
  • 組織特異性：
    Ubiquitously expressed with highest levels in heart and lung.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产一卡三卡四卡无卡精品| 熟妇好大好深好满好爽| 老熟女毛茸茸浓毛| 日韩av无码社区一区二区三区| 亚洲欧洲综合有码无码| 欧美老熟妇乱xxxxx| 无码免费毛片手机在线无卡顿 | 久久成人网站亚洲综合| 青青草原亚洲| 欧洲熟妇色xxxxx欧美老妇伦| 大桥未久亚洲一区二区| 久久只有这里有精品4| 激情欧美成人久久综合| 精品人妻伦一二三区久久| 精品麻豆丝袜高跟鞋av| 亚洲欧美日产综合在线| 无码毛片内射白浆视频| 热久久美女精品天天吊色| 日本毛茸茸的丰满熟妇| 狠狠噜天天噜日日噜视频跳一跳| 好吊色欧美一区二区三区视频| 国产精品乱码人妻一区二区三区| 亚洲无日韩码精品| 国产精品 欧美 亚洲 制服 | 亚洲一区二区女搞男| 国产超碰人人做人人爽av动图| 亚洲综合区图片小说区| 国语精品一区二区三区| 国产成人欧美亚洲日韩电影| 天天爽天天爽天天片a| 情侣做性视频在线播放| 欧美大片va欧美在线播放| 人妻丰满熟妇a无码区| 少妇愉情理伦片bd| 成人午夜视频精品一区| 2021久久精品国产99国产精品| 欧美成人www免费全部网站| 少妇无码吹潮| 青草青草久热国产精品| 日本高清无卡码一区二区| 强行糟蹋人妻hd中文字幕 |