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Recombinant Mouse Hyaluronan-binding protein 2 (Habp2)

  • 中文名稱:
    小鼠Habp2重組蛋白
  • 貨號:
    CSB-YP814290MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Habp2重組蛋白
  • 貨號:
    CSB-EP814290MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Habp2重組蛋白
  • 貨號:
    CSB-EP814290MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Habp2重組蛋白
  • 貨號:
    CSB-BP814290MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Habp2重組蛋白
  • 貨號:
    CSB-MP814290MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Habp2
  • Uniprot No.:
  • 別名:
    Habp2; Phbp; Hyaluronan-binding protein 2; EC 3.4.21.-; Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    24-311
  • 氨基酸序列
    LSLMSFI APPDPDWTPD DYYYSYEQSS PDEDPSVTQT TPENPDWYYE DDDPCQSNPC EHGGDCIIRG DTFSCSCPAP FSGSRCQTAQ NKCKDNPCVH GDCLITQKHP YYRCACKYPY TGPDCSKVLP ACRPNPCQNG GVCSRHRRRS RFTCACPDQY KGKFCEIGPD DCYVGDGYSY RGKVSKTVNQ NPCLYWNSHL LLQETYNMFM EDAETHGIAE HNFCRNPDGD HKPWCFVKVN SEKVKWEYCD VTVCPVPDTP NPVESLLEPV MELPGFESCG KTEVAEHAVK R
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.
  • 基因功能參考文獻:
    1. FSAP deficiency causes an increase in CCL2 expression and CCL2-mediated infiltration of leukocytes into the injured vessel PMID: 27431088
    2. the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta, was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD binding sites. PMID: 27462075
    3. Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice. PMID: 25427855
    4. Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT pathway PMID: 25615590
    5. Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury. PMID: 22989567
    6. Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2). PMID: 23341458
    7. Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA/Rho kinase signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability. PMID: 20042707

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  • 亞細胞定位:
    Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
  • 蛋白家族:
    Peptidase S1 family
  • 組織特異性:
    Liver and kidney.
  • 數據庫鏈接:

    KEGG: mmu:226243

    UniGene: Mm.25791



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