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  4. Recombinant Mouse Huntingtin-interacting protein K (Hypk)

Recombinant Mouse Huntingtin-interacting protein K (Hypk)

  • 中文名稱：
    小鼠Hypk重組蛋白
  • 貨號：
    CSB-YP863434MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hypk重組蛋白
  • 貨號：
    CSB-EP863434MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hypk重組蛋白
  • 貨號：
    CSB-EP863434MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hypk重組蛋白
  • 貨號：
    CSB-BP863434MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hypk重組蛋白
  • 貨號：
    CSB-MP863434MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hypk
  • Uniprot No.：
  • 別名：
    Hypk; Huntingtin-interacting protein K; Huntingtin yeast partner K
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-129
  • 氨基酸序列
    MRRRGEIEMA TEGDVELELE TETSGPERPP EKPRKHDSGA ADLERVTDYA EEKEIQSSNL ETAMSVIGDR RSREQKAKQE REKELAKVTI KKEDLELIMT EMEISRAAAE RSLREHMGNV VEALIALTN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of several N-terminal acetyltransferase complexes. Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex. May play a role in the NatA complex-mediated N-terminal acetylation of PCNP.
  • 基因功能參考文獻：
    1. HYPK can act as negative regulator of heat shock response by repressing transcriptional activity of HSF1. PMID: 27017930
    2. specific interaction of HYPK with HTT-N17 is crucial for the chaperone activity of HYPK PMID: 25446099
    3. HYPK has roles in regulating cell growth, cell cycle, unfolded protein response and cell death PMID: 23272104
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 數據庫鏈接：


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