在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Huntingtin-interacting protein 1 (Hip1), partial

Recombinant Mouse Huntingtin-interacting protein 1 (Hip1), partial

  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-YP848681MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-EP848681MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-EP848681MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-BP848681MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-MP848681MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hip1; Kiaa4113Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein I; HIP-I
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
  • 基因功能參考文獻：
    1. we show that M. tuberculosis impairs dendritic cell cytokine secretion, maturation, and antigen presentation through the cell envelope-associated serine hydrolase, Hip1. PMID: 24659689
    2. HIP1 association with and phosphorylation mediated by EGFR and EGFRvIII. PMID: 23836884
    3. Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit PMID: 21697888
    4. Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathw PMID: 11788820
    5. HIP1 is the first endocytic protein to be directly implicated in tumor formation PMID: 12781365
    6. disuprtion results in neurological deficits and decreased AMPA receptor trafficking PMID: 12839988
    7. three different mutations lead to hematopoietic abnormalities reflected by diminished early progenitor frequencies PMID: 14998932
    8. mice deficient in both HIP1 and HIP1r have accelerated development of abnormalities seen in Hip1 -deficient mice, including kypholordosis and growth defects PMID: 15121852
    9. The various abnormalities corroborate reduced fertility levels in HIP1(-/-) mice and suggest a role for HIP1 in stabilizing actin and microtubules, enabling normal spermatid and Sertoli cell morphology and function. PMID: 16967501
    10. we have shown that HIP1 influences important NMDAR functions and that both HIP1 and htt participate in NMDA-induced cell death. PMID: 17329427
    11. Degenerative phenotypes seen in knockout mice are due mainly to HIP1 and HIP1r protein deficiency rather than altered expression of neighboring genes or disrupted intronic elements. PMID: 17452370
    12. Presynaptic function is altered in hippocampal brain slices of HIP1-deficient mice demonstrating delayed recovery from synaptic depression and a reduction in paired-pulse facilitation. PMID: 17928447
    13. The presence of a 110-kDa form of HIP1 in tumor cells was discovered. Upon sequencing of Hip1 DNA and message from these tumors, it was seen that this 110-kDa form of HIP1 is the product of splicing of a cryptic U12-type AT-AC intron. PMID: 18281481
    14. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain PMID: 18790740

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane.
  • 蛋白家族：
    SLA2 family
  • 組織特異性：
    Most abundantly expressed in brain. In brain, expressed in cortical tissue, hippocampus, the molecular layer of the cerebellum and olfactory bulb. Also expressed in spinal cord and bone marrow (at protein level). Expressed in reproductive tissues.
  • 數據庫鏈接：


主站蜘蛛池模板： 无码一区二区| 丰满白嫩人妻中出无码| 中文字幕美人妻亅u乚一596| 97免费人妻无码视频| 色婷婷国产精品高潮呻吟av久久| 无码一区二区三区av免费蜜桃| 久久久亚洲一区二区三区| 日本真人做爰免费的视频| 国产高清乱码又大又圆| 亚洲人成人无码网www电影首页| 人妻熟女一区二区aⅴ千叶宁真 | 久久青草费线频观看| 老熟女高潮一区二区三区| 很黄很色的动态图580期| 久久亚洲道色宗和久久| 免费国产黄网站在线观看可以下载| 中文字幕无线码中文字幕免费| 成品人视频ww入口| 亚洲三区在线观看内射后入 | 玩50岁四川熟女大白屁股直播| 国精产品一区二区三区有限公司| 国产男女免费完整视频| 非洲黑人性xxxx精品| 亚洲欧美日韩国产国产a| 综合 欧美 亚洲日本| 久久精品无码一区二区无码| 欧美香蕉爽爽人人爽| 亚洲第一福利网站在线观看| 狠狠cao日日穞夜夜穞av| 日本人妻伦在线中文字幕| 日本高清在线www3344| 18禁免费吃奶摸下激烈视频| 欧美精品久久天天躁| 加勒比无码人妻东京热| 亚洲国产区男人本色vr| 99久热re在线精品99 6热视频 | 亚洲色成人网站www永久蜜芽| 国产av国片精品有毛| 久久精品国产丝袜人妻| 亚洲熟妇无码八av在线播放| 天堂在线最新版资源www|