在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Huntingtin-interacting protein 1 (Hip1), partial

Recombinant Mouse Huntingtin-interacting protein 1 (Hip1), partial

  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-YP848681MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-EP848681MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-EP848681MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-BP848681MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hip1重組蛋白
  • 貨號：
    CSB-MP848681MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hip1; Kiaa4113Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein I; HIP-I
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
  • 基因功能參考文獻：
    1. we show that M. tuberculosis impairs dendritic cell cytokine secretion, maturation, and antigen presentation through the cell envelope-associated serine hydrolase, Hip1. PMID: 24659689
    2. HIP1 association with and phosphorylation mediated by EGFR and EGFRvIII. PMID: 23836884
    3. Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit PMID: 21697888
    4. Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathw PMID: 11788820
    5. HIP1 is the first endocytic protein to be directly implicated in tumor formation PMID: 12781365
    6. disuprtion results in neurological deficits and decreased AMPA receptor trafficking PMID: 12839988
    7. three different mutations lead to hematopoietic abnormalities reflected by diminished early progenitor frequencies PMID: 14998932
    8. mice deficient in both HIP1 and HIP1r have accelerated development of abnormalities seen in Hip1 -deficient mice, including kypholordosis and growth defects PMID: 15121852
    9. The various abnormalities corroborate reduced fertility levels in HIP1(-/-) mice and suggest a role for HIP1 in stabilizing actin and microtubules, enabling normal spermatid and Sertoli cell morphology and function. PMID: 16967501
    10. we have shown that HIP1 influences important NMDAR functions and that both HIP1 and htt participate in NMDA-induced cell death. PMID: 17329427
    11. Degenerative phenotypes seen in knockout mice are due mainly to HIP1 and HIP1r protein deficiency rather than altered expression of neighboring genes or disrupted intronic elements. PMID: 17452370
    12. Presynaptic function is altered in hippocampal brain slices of HIP1-deficient mice demonstrating delayed recovery from synaptic depression and a reduction in paired-pulse facilitation. PMID: 17928447
    13. The presence of a 110-kDa form of HIP1 in tumor cells was discovered. Upon sequencing of Hip1 DNA and message from these tumors, it was seen that this 110-kDa form of HIP1 is the product of splicing of a cryptic U12-type AT-AC intron. PMID: 18281481
    14. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain PMID: 18790740

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane.
  • 蛋白家族：
    SLA2 family
  • 組織特異性：
    Most abundantly expressed in brain. In brain, expressed in cortical tissue, hippocampus, the molecular layer of the cerebellum and olfactory bulb. Also expressed in spinal cord and bone marrow (at protein level). Expressed in reproductive tissues.
  • 數據庫鏈接：


主站蜘蛛池模板： 四川骚妇无套内射舔了更爽| 亚洲人成精品久久久久| 中文字幕日韩精品亚洲一区 | 久久精品天天中文字幕人妻| 亚洲熟女www一区二区三区| 国产网红主播无码精品| 亚洲中文字幕av不卡无码| 97夜夜澡人人双人人人喊| 野花社区在线观看视频| 女人裸体性做爰视频| 国内精品久久久久影院老司机 | 亚洲精品456在线播放 | 欧美成aⅴ人高清免费| 日韩亚洲国产高清免费视频| 国产波霸爆乳一区二区| 午夜时刻免费入口| 国内精品美女a∨在线播放| 国产精品无码嫩草地址更新| 特大巨黑吊xxxx高潮| 国产在线精品99一卡2卡| 69风韵老熟女口爆吞精| 东北老女人高潮大叫对白| 欧洲熟妇色xxxx欧美老妇| aa区一区二区三无码精片| 国产牛仔裤网站精品| 综合网日日天干夜夜久久| 国产又色又爽又黄好看的视频| 成在人线av无码免费看网站| 天天干天天日夜夜操| 欧美人与物videos另类xxxxx| 综合激情亚洲丁香社区| 少妇富婆高级按摩出水高潮| 夜夜爽妓女8888视频免费观看| 中无码人妻丰满熟妇啪啪| 精品无码久久久久久尤物| 欧美老人巨大xxxx做受| 人人妻一区二区三区| 日韩国产亚洲一区二区三区| 99久久久精品免费观看国产| 亚洲国产成人片在线观看无码| 久久青草成人综合网站|