在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Homeobox protein Meis2 (Meis2)

Recombinant Mouse Homeobox protein Meis2 (Meis2)

  • 中文名稱：
    小鼠Meis2重組蛋白
  • 貨號：
    CSB-YP013687MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Meis2重組蛋白
  • 貨號：
    CSB-EP013687MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Meis2重組蛋白
  • 貨號：
    CSB-EP013687MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Meis2重組蛋白
  • 貨號：
    CSB-BP013687MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Meis2重組蛋白
  • 貨號：
    CSB-MP013687MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Meis2
  • Uniprot No.：
  • 別名：
    Meis2; Mrg1; Stra10; Homeobox protein Meis2; Meis1-related protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-477
  • 氨基酸序列
    MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM GMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMVM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms Meis2B and Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription.
  • 基因功能參考文獻(xiàn)：
    1. Study identifies Meis2 as a subclass-specific marker for 5-HT3AR-containing interstitial interneurons and demonstrates that the transcriptional and anatomical parcellation of cortical interneurons is developmentally coupled. PMID: 28134272
    2. identified Meis2 as critical to MN1-induced leukemia, with essential roles in proliferation, self-renewal, impairment of differentiation and disease progression in vitro and in vivo. PMID: 28960191
    3. MEIS2 associates with chromatin-bound PBX1, recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber. PMID: 28739678
    4. An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer. PMID: 28041912
    5. Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression. PMID: 27287804
    6. Meis2-null mice are embryonic lethal. The results reveal a critical role of Meis2 during cranial and cardiac neural crest cells development in mouse. PMID: 26545946
    7. Data suggest that the RING1-MEIS1/2 axis is regulated by early PD signals and contributes to the initiation or maintenance of the distal signal circuitry. PMID: 26674308
    8. Interaction of Meis2 promoter with midbrain enhancer depends on RING1. PMID: 24374176
    9. Meis2 cooperates with Pax6 in generic neurogenesis and dopaminergic fate specification in the adult subventricular zone-olfactory bulb system. PMID: 24284204
    10. These data identify Meis2 as a marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during AM cell differentiation. PMID: 17729288

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, perinuclear region.
  • 蛋白家族：
    TALE/MEIS homeobox family
  • 組織特異性：
    Displays spatially restricted expression patterns in the developing nervous system, limbs, face, and in various viscera. In adult, it is mainly expressed in the brain and female genital tract, with a different distribution of the alternative splice forms
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 成熟女人特级毛片www免费| 亚洲日韩一区二区三区| 18禁裸体女免费观看| 亚洲中文字幕久久无码| 狠狠躁夜夜躁人人爽天天| а√天堂www在线а√天堂资源 | 国产美女精品视频线播放| 亚洲欧美精品午睡沙发| 成人免费视频一区二区| 97视频精品全国免费观看| 国产l精品国产亚洲区| 久久国产成人精品av| 久久不见久久见中文字幕免费| 无码专区 丝袜美腿 制服师生| 国产熟妇人妻精品一区二区动漫| 少妇无码一区二区三区免费| 人人妻人人狠人人爽| 亚洲亚洲熟妇色l图片20p| 中文字字幕在线精品乱码| 欧美三级午夜理伦三级| 久久99精品久久久久婷婷| 国产成人精品福利一区二区三区| 久久久国产99久久国产久一| 国产精品va在线观看无码不卡| 色老久久精品偷偷鲁| 欧美日韩一卡2卡三卡4卡 乱码欧美孕交| av国産精品毛片一区二区视频 | 国产综合18久久久久久| 性久久久久久久| 国产精品理论片在线观看| 国产成人亚洲精品无码车a| 日韩无套无码精品| 婷婷四房综合激情五月| 午夜精品久久久久久久四虎| 强行从后面挺进人妻| 亚洲精品国产精品国自产| 亚洲处破女av日韩精品| 日本工口里番无遮█彩色| 中文字幕亚洲一区二区三区| 国产精品9999久久久久仙踪林 | 精品999日本久久久影院|