在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Histone-lysine N-methyltransferase SETDB1 (Setdb1), partial

Recombinant Mouse Histone-lysine N-methyltransferase SETDB1 (Setdb1), partial

  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-YP021110MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-EP021110MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-EP021110MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-BP021110MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-MP021110MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Setdb1; Eset; Kiaa0067; Histone-lysine N-methyltransferase SETDB1; EC 2.1.1.-; ERG-associated protein with SET domain; ESET; SET domain bifurcated 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway. Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily
  • 組織特異性：
    Ubiquitously expressed. Strong expression in liver and testis. Expressed in the brain, lungs, kidneys, uterus and seminal vesicles.
  • 數據庫鏈接：


主站蜘蛛池模板： 中文字幕无码无码专区| 国产在线观看免费视频软件 | 97爱亚洲综合成人| 天天躁日日躁狠狠躁欧美老妇| 国产69久久精品成人看| 一本色道久久88综合日韩精品| 国产精品亚洲w码日韩中文| 欧美做受视频播放| 人妻熟女一区二区三区app下载| 中文字幕日韩一区二区三区不卡| 色综合久久中文娱乐网| 国产无遮挡乱子伦免费精品| 午夜亚洲精品久久一区二区| 无码av免费一区二区三区| 日韩乱码人妻无码系列中文字幕| 亚洲已满18点击进入在线观看| 人妻被按摩到潮喷中文不卡| 免费人成视频x8x8| 国产亚洲精品久久久久5区| 永久免费的啪啪网站免费观看| 亚洲成a∧人片在线播放无码| 色欲国产麻豆一精品一av一免费 | 激情av无码后入| 影音先锋男人av鲁色资源网| 色婷婷日日躁夜夜躁| 一二三四视频社区3在线高清| 日韩精品电影综合区亚洲| 波多野结衣不打码视频| 肉大榛一进一出免费视频| 人人澡人人曰人人摸看| 人妻丰满熟av无码区hd| 久久这里只精品国产免费10 | 日日噜噜噜夜夜爽爽狠狠视频| 精品国产一区二区av麻豆不卡| 亚洲精品综合欧美一区二区| 色婷婷欧美在线播放内射| 色与欲影视天天看综合网| 国偷自产一区二区三区在线视频| 夜夜躁天天躁很很躁| 国产精品v欧美精品∨日韩| 亚洲国产精品无码中文在线|