在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Histone-lysine N-methyltransferase SETDB1 (Setdb1), partial

Recombinant Mouse Histone-lysine N-methyltransferase SETDB1 (Setdb1), partial

  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-YP021110MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-EP021110MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-EP021110MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-BP021110MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Setdb1重組蛋白
  • 貨號：
    CSB-MP021110MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Setdb1; Eset; Kiaa0067; Histone-lysine N-methyltransferase SETDB1; EC 2.1.1.-; ERG-associated protein with SET domain; ESET; SET domain bifurcated 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway. Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily
  • 組織特異性：
    Ubiquitously expressed. Strong expression in liver and testis. Expressed in the brain, lungs, kidneys, uterus and seminal vesicles.
  • 數據庫鏈接：


主站蜘蛛池模板： 久久国产精品无码hdav| 欧美丰满熟妇xx猛交| 国产精品久久久久av福利动漫| 日本不卡不码高清视频| 成 人影片 免费观看在线| 精品一卡2卡三卡4卡免费网站| 最近更新中文字幕| 午夜性开放午夜性爽爽| 亚洲乱码中文论理电影| 国内精品一区二区三区| 极品少妇xxxx| 欧美阿v天堂视频在99线| 18禁精品久久久国产精品久久久| 国产精品无码av一区二区三区| 日本免费一区二区三区四区五六区| 三级做a全过程在线观看| 56pao国产成视频永久| 无套中出丰满人妻无码| 欧美性生交大片免费看| 亚洲乱码卡一卡二卡| 久久精品国产亚洲αv忘忧草| 色婷婷综合激情综在线播放| 又粗又硬整进去好爽视频| 久久久亚洲欧洲日产国码二区| 一本久久精品一区二区| 亚洲阿v天堂在线| 日韩精品无码免费专区午夜不卡 | 奇米影视第4色| 欧美 亚洲 国产 日韩 综aⅴ| 国产亚洲另类无码专区| 男人添女人囗交做爰视频| 色又黄又爽18禁免费网站现观看| 西西人体大胆啪啪实拍| 亚洲熟妇无码av不卡在线| 少妇极品熟妇人妻无码| 成人亚欧欧美激情在线观看| 欧美成人无码a区视频在线观看| 明星性猛交ⅹxxx乱大交| 久艹视频免费看| 在线看午夜福利片国产| 久久天天躁狠狠躁夜夜avapp|