在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Histone-lysine N-methyltransferase EHMT1 (Ehmt1), partial

Recombinant Mouse Histone-lysine N-methyltransferase EHMT1 (Ehmt1), partial

  • 中文名稱：
    小鼠Ehmt1重組蛋白
  • 貨號：
    CSB-YP685633MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ehmt1重組蛋白
  • 貨號：
    CSB-EP685633MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ehmt1重組蛋白
  • 貨號：
    CSB-EP685633MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ehmt1重組蛋白
  • 貨號：
    CSB-BP685633MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ehmt1重組蛋白
  • 貨號：
    CSB-MP685633MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ehmt1
  • Uniprot No.：
  • 別名：
    Ehmt1; Euhmtase1; Glp; Kmt1dHistone-lysine N-methyltransferase EHMT1; EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 1; Eu-HMTase1; G9a-like protein 1; GLP; GLP1; Lysine N-methyltransferase 1D
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader Baz2b.
  • 基因功能參考文獻：
    1. reduced levels of EHMT1 protein in Ehmt1(+/-) mice does not result in general learning deficits in a touchscreen-based battery, but leads to increased adult cell proliferation in the hippocampus and enhanced pattern separation ability. PMID: 28071689
    2. EHMT1 deficiency impaired neural network activity during the transition from uncorrelated background action potential firing to synchronized network bursting. Spontaneous bursting and excitatory synaptic currents were transiently reduced, whereas miniature excitatory postsynaptic currents were not affected. PMID: 27767173
    3. GLP/G9a H3K9 methyltransferase complex is an enzyme counteracting Jmjd1a-mediated H3K9 demethylation at the Sry locus in gonadal somatic cells PMID: 28949961
    4. miR-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathological hypertrophy PMID: 27893464
    5. EHMT1 Mediates Homeostatic Synaptic Scaling PMID: 27373831
    6. The stress-induced Brg1-G9a/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals. PMID: 26952936
    7. data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 are epigenetic regulators involved in gamma-globin repression and represent a novel therapeutic target for SCD. PMID: 26320100
    8. histone methyltransferase activities of GLP and G9a are stimulated by neighboring nucleosomes that are premethylated at H3K9 PMID: 25637356
    9. Prdm16 was required in young mice to suppress the expression of white-fat-selective genes in BAT through recruitment of the histone methyltransferase Ehmt1. PMID: 24703692
    10. G9a and GLP have an essential role in normal morphogenesis of the atrioventricular septum through regulation of the size of the atrioventricular cushion. PMID: 23892084
    11. Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice. PMID: 24362066
    12. EHMT1 is an essential BAT-enriched lysine methyltransferase in the PRDM16 transcriptional complex and controls brown adipose cell fate PMID: 24196706
    13. These data demonstrate that Ehmt1 haploinsufficiency in mice leads to learning deficits and synaptic dysfunction, providing a possible mechanism for the ID phenotype in patients with Kleefstra syndrome PMID: 23175442
    14. Metallothionein 1 h tumour suppressor activity in prostate cancer is mediated by euchromatin methyltransferase 1. PMID: 23355073
    15. EHMT1 protein binds to nuclear factor-kappaB p50 and represses gene expression. PMID: 22801426
    16. These studies demonstrate, for the first time, that sitagliptin exerts direct, DPP-IV-independent effects on intestinal L cells, activating cAMP and ERK1/2 signaling and stimulating total GLP-1 secretion. PMID: 22186413
    17. LSH is essential for developmentally programmed de novo DNA methylation at the promoters of protein coding genes and recruitment of G9a/GLP complex to a subset of genomic loci. PMID: 21149390
    18. These observations make it plausible that the Ehmt1(+/-) mouse is a faithful mammalian model for the autistic-like behavioral features of patients with the 9q34.3 subtelomeric deletion syndrome. PMID: 19896504
    19. Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells. PMID: 16702210

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Note=Associates with euchromatic regions.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品亚洲а∨天堂免下载| 色偷偷888欧美精品久久久| 欧美一区二区| 免费1级a做爰片观看| 人人婷婷人人澡人人爽| 99久久久无码国产精品免费砚床| 人人超人人超碰超国产97超碰| 97se亚洲国产综合自在线观看| 新版天堂资源中文www连接| 亚洲不卡1卡2卡三卡入口| 青青草原精品99久久精品66| 国产在线 | 中文| 麻豆精产一二三产区| 国产亚洲精品自在久久蜜tv| 久久久久久久久蜜桃| r级无码视频在线观看| 色九月亚洲综合网| 久久婷婷五月综合色奶水99啪 | 国内老熟妇乱子伦视频| 国产精品美女久久久| 高清无码一区二区在线观看吞精| 久久久久久无码日韩欧美| 无码一区二区三区av在线播放| 欧美牲交a欧牲交aⅴ久久| 天天做天天爱天天综合网2021| 国内一区二区三区香蕉aⅴ| 无码午夜福利片| 欧美 日韩 人妻 高清 中文| 成在人线av无码免费高潮水老板| 午夜人成免费视频| 99国产精品久久久久久久成人热 | 无码国产精品一区二区免费i6 | 乱中年女人伦av三区| 午夜理论片yy44880影院| 亚洲日韩小电影在线观看| 国产第一页浮力影院草草| 国产熟女一区二区三区五月婷| 亚洲一二三四2021不卡| 国产亚洲人成无码网在线观看| 又色又爽又黄的视频网站| 日本黄页网站免费观看|