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  4. Recombinant Mouse High mobility group protein 20A (Hmg20a)

Recombinant Mouse High mobility group protein 20A (Hmg20a)

  • 中文名稱：
    小鼠Hmg20a重組蛋白
  • 貨號：
    CSB-YP880566MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hmg20a重組蛋白
  • 貨號：
    CSB-EP880566MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hmg20a重組蛋白
  • 貨號：
    CSB-EP880566MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hmg20a重組蛋白
  • 貨號：
    CSB-BP880566MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hmg20a重組蛋白
  • 貨號：
    CSB-MP880566MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hmg20a
  • Uniprot No.：
  • 別名：
    Hmg20a; IbrafHigh mobility group protein 20A; HMG box-containing protein 20A; HMG domain-containing protein HMGX1; Inhibitor of BRAF35; iBRAF
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-346
  • 氨基酸序列
    MESLMASSTL PPLFADEDGS KESNDLATSG LTHPEGPYGS AATSTTNPEF VEDLSQGQLL QSEASNAVEG NEQRPEDEQR SKRGGWSKGR KRKKPLRDSN APKSPLTGYV RFMNERREQL RAKRPEVPFP EITRMLGNEW SKLPPEEKQR YLDEADRDKE RYMKELEQYQ KTEAYKVFSR KTQDRQKGKS HRQDAARQAT HDHEKETEVK ERSVFDIPIF TEEFLNHSKA REAELRQLRK SNMEFEERNA ALQKHVESMR TAVEKLEVDV IQERSRNTVL QQHLETLRQM LTSSFASMPL PGSGEIPTVD TIDSYMNRLH SIILANPQDN ENFIATVREV VNRLDR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4.
  • 基因功能參考文獻：
    1. ectopic expression of BRAP2 inhibits nuclear localization of HMG20A and NuMA1, and prevents nuclear envelope accumulation of SYNE2. PMID: 23707952
    2. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35 PMID: 20530487
    3. Ectopic expression of iBRAF induces neuronal differentiation through recruitment of MLL, resulting in increased histone H3K4 trimethylation and activation of neuronal-specific genes. PMID: 16227968
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in brain. Detected in mature neurons.
  • 數據庫鏈接：


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