在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Growth factor receptor-bound protein 14 (Grb14)

  • 中文名稱:
    小鼠Grb14重組蛋白
  • 貨號:
    CSB-YP009888MO
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Grb14重組蛋白
  • 貨號:
    CSB-EP009888MO
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Grb14重組蛋白
  • 貨號:
    CSB-EP009888MO-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Grb14重組蛋白
  • 貨號:
    CSB-BP009888MO
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Grb14重組蛋白
  • 貨號:
    CSB-MP009888MO
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Grb14
  • Uniprot No.:
  • 別名:
    Grb14; Growth factor receptor-bound protein 14; GRB14 adapter protein
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-538
  • 氨基酸序列
    TTSLQDGQS AAGRAGAQDS PLAVQVCRVA QGKGDAQDPA QVPGLHALSP ASDATLRGAI DRRKMKDLDV LEKPPIPNPF PELCCSPLTS VLSAGLFPRA NSRKKQVIKV YSEDETSRAL EVPSDITARD VCQLLILKNH YVDDNSWTLF EHLSHIGLER TVEDHELPTE VLSHWGVEED NKLYLRKNYA KYEFFKNPMY FFPEHMVSFA AEMNGDRSPT QILQVFLSSS TYPEIHGFLH AKEQGKKSWK KAYFFLRRSG LYFSTKGTSK EPRHLQLFSE FSTSHVYMSL AGKKKHGAPT PYGFCLKPNK AGGPRDLKML CAEEEQSRTC WVTAIRLLKD GMQLYQNYMH PYQGRSACNS QSMSPMRSVS ENSLVAMDFS GEKSRVIDNP TEALSVAVEE GLAWRKKGCL RLGNHGSPSA PSQSSAVNMA LHRSQPWFHH RISRDEAQRL IIRQGPVDGV FLVRDSQSNP RTFVLSMSHG QKIKHYQIIP VEDDGELFHT LDDGHTKFTD LIQLVEFYQL NRGVLPCKLK HYCARMAV
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
  • 基因功能參考文獻:
    1. Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways. PMID: 27215388
    2. The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor signaling. PMID: 24350791
    3. Grb14 is a normal physiological modulator of CNG channel function in vivo. PMID: 20890309
    4. Grb14 functions in vivo as a tissue-specific modulator of insulin action, most likely via repression of IR-mediated IRS-1 tyrosine phosphorylation PMID: 14749734
    5. regulation of Grb14 expression in adipose tissue may play a physiological role in insulin sensitivity PMID: 15059968
    6. Grb14 exerts a dual role on the regulation by insulin of hepatic metabolism. It inhibits insulin receptor catalytic activity, and as a sterol regulatory element binding protein-1c maturation. PMID: 18339716
    7. These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation. PMID: 19438210
    8. Grb10 and Grb14 have roles in regulation of insulin signaling and glucose homeostasis PMID: 19541746

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族:
    GRB7/10/14 family
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美性猛交xxxx乱大交蜜桃| 麻豆精品国产精华精华液好用吗| 色护士极品影院| 97成人碰碰久久人人超级碰oo| 伊人蕉影院久亚洲高清| 女上男下啪啪激烈高潮无遮盖 | 国产开嫩苞实拍在线播放视频 | 精品一区二区三区免费毛片爱 | 欧美潮喷少妇100| 国产精品成熟老女人| 又大又黄又粗又爽的免费视频| 最新精品视频2019在线视频| 成人爽a毛片在线视频淮北| 伊人久久综合色| 成人无码一区二区三区| 日本一道综合久久aⅴ久久| 精品一卡2卡三卡4卡乱码精品视频 | 天天做天天欢摸夜夜摸狠狠摸| 牛和人交videos欧美| 免费裸体美女网站| 亚洲综合在线另类色区奇米| 黄网站色视频免费观看| 国产免码va在线观看免费| 成在人线av无码免费| 国产av久久人人澡人人爱| 精品免费国偷自产在线视频| 亚洲无av在线中文字幕| 国产suv精品一区二人妻| 无码国产玉足脚交极品网站| 天天天天躁天天爱天天碰| 性开放的女人aaa片| 边吃奶边添下面好爽| 亚洲日韩va在线视频| 亚洲熟妇丰满多毛xxxx| 色五月五月丁香亚洲综合网| 久久亚洲精品成人无码网站夜色| 无码毛片一区二区本码视频| 57pao成人国产永久免费视频| 亚洲va综合va国产产va中文| 亚洲精品美女久久777777| 欧美人妻aⅴ中文字幕|