在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Growth/differentiation factor 5 (Gdf5)

  • 中文名稱:
    小鼠Gdf5重組蛋白
  • 貨號:
    CSB-EP009349MO
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Gdf5; Bmp14; Bp; Gdf-5Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14; BMP-14
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    17.6kDa
  • 表達區域:
    376-495aa
  • 氨基酸序列
    APLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
  • 基因功能參考文獻:
    1. Microarray analysis of satellite cells showed that expression of growth differentiation factor 5 (Gdf5) mRNA was markedly increased in Dnmt3a-KO mice. The DNA methylation level of the Gdf5 promoter was markedly decreased in Dnmt3a-KO satellite cells. PMID: 29146735
    2. spatiotemporal dynamics of Gdf5 expression may instruct lineage divergence. PMID: 27292641
    3. he large array of modular enhancers for Gdf5 provide a new foundation for studying the spatial specificity of joint patterning in vertebrates, as well as new candidates for regulatory regions that may also influence osteoarthritis risk in human population PMID: 27902701
    4. Growth differentiation factor 5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation. PMID: 26878848
    5. Dach2 and Hdac9 mediate the effects of muscle activity on muscle reinnervation; Myog and Gdf5 appear to stimulate muscle reinnervation through parallel pathways PMID: 26483211
    6. Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis. PMID: 26141957
    7. GDF5 might play a critical role in 3T3-L1 preadipocyte differentiation PMID: 25078108
    8. These results suggest that PI3K/Akt signals play a role in the GDF5-mediated brown adipogenesis through a mechanism related to activation of the Smad pathway. PMID: 24944017
    9. These results suggest that brown adipogenesis and energy homeostasis are both positively regulated by the GDF5/BMPR/Smad/PGC-1alpha signaling pathway in adipose tissues. PMID: 24062245
    10. apical and basal dendritic arbours of pyramidal cells throughout the hippocampus were stunted in both homozygous and heterozygous Gdf5 null mutants, indicating that dendrite size and complexity are sensitive to the level of endogenous GDF5 synthesis. PMID: 24173804
    11. This work implicates SOX11 as a potential regulator of GDF5 expression in joint maintenance and suggests a possible role in the pathogenesis of osteoarthritis PMID: 23356643
    12. A novel molecular mechanism of a GDF5 mutation affecting chondrogenesis and osteogenesis, is reported. PMID: 21976273
    13. Data show that revealed notochord cells in Gdf-5-null mice correctly form nuclei pulposi. PMID: 21278629
    14. Although GDF-5 deficiency did not compromise long-term fracture healing, a delay in cartilage formation and remodeling supports roles for GDF-5 in the early phase of bone repair. PMID: 21590487
    15. data suggest that decreased GDF5 levels in mice can contribute to osteoarthritis development by different mechanisms including altered loading and subchondral bone changes. PMID: 20805298
    16. potential target gene of HOXA13 PMID: 20034107
    17. These observations indicate that GDF-5 regulates differentiation of both dental papilla and follicle during odontogenesis, co-operatively with other growth factors such as BMP-2. PMID: 19909214
    18. GDF5 deficiency caused a 17% increase in medium diameter (100-225 nm) collagen fibrils in tail tendon, at the expense of larger fibrils. Thus, GDF5 may play a role in tendon homeostasis in mice. PMID: 11913489
    19. GDF-5-deficient femora were weaker (-31%) and more compliant (-57%) than controls when tested to failure in torsion. PMID: 11996912
    20. GDF-5 induced cell cycle arrest in the G1 phase before the appearance of apoptosis in mouse B cell hybridoma HS-72 cells PMID: 12464389
    21. role of single and double mutations in the mouse Gdf6 and Gdf5 genes in multiple joint and skeletal patterning defects PMID: 12606286
    22. GDF5 regulates expression of connexin 43 promoter in osteoblasts ans embryos PMID: 12881039
    23. GDF-5 may play an important role in modulating tendon repair. Data are consistent with previously posited roles for GDF-5 in cell recruitment, migration/adhesion, differentiation, proliferation, and angiogenesis. PMID: 12919870
    24. concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis PMID: 14613311
    25. GDF-5 synergistically enhances de novo bone formation capability of bone marrow mesenchymal cells in hyaluronan composites in rats. PMID: 14661262
    26. GDF5 has a role in growth of developing joints, including early joint interzones, adult articular cartilage, and the joint capsule PMID: 15492776
    27. Excessive apoptosis in the absence of GDF5 results in developmental failure of the phalanges. PMID: 15542031
    28. Deficiency in knockout mice affects biomechanical behavior and ultrastructure of mouse skin. PMID: 16112556
    29. Results describe 2 mutations in growth and differentiation factor 5 (GDF5) that alter receptor-binding affinities. PMID: 16127465
    30. Results suggest that CDMP1/GDF5 requires cleavage by two distinct proteolytic enzymes. PMID: 16829522
    31. Study further highlights a critical role of GDF5 in joint formation and the development of osteoarthritis (OA), and this should serve as a good model for OA. PMID: 17656374
    32. association of Gdf5-mediated signaling pathways with Trps1 and the phenotypic changes of ATDC5 cells due to over-expression or suppression of Trps1 PMID: 18363966
    33. Absence of GDF5 does not interfere with lipopolysaccharides toll-like receptor signaling in a mouse model of arthritis. PMID: 19604444

    顯示更多

    收起更多

  • 相關疾病:
    Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton.
  • 亞細胞定位:
    Secreted. Cell membrane.
  • 蛋白家族:
    TGF-beta family
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美成人免费va影院高清| 日韩激情无码免费毛片| 秋霞午夜久久午夜精品| 国产精品亚洲专区无码老司国 | 思思久久99热只有频精品66 | 国产精品无码天天爽视频| 人妻 日韩 欧美 综合 制服| 乱人伦xxxx国语对白| 2019亚洲午夜无码天堂| 成人午夜亚洲精品无码区| 区二区欧美性插b在线视频网站| 国产xxxx做受性欧美88| 国产偷窥熟精品视频| 美女又色又爽视频免费| 欧美另类videosbestsex日本| 国产又爽又黄又不遮挡视频| 国产成人无码av在线播放不卡| 一本热久久sm色国产| 国産精品久久久久久久| 国产午夜亚洲精品不卡| 999久久久精品国产消防器材| 国产情侣一区二区| 欧美在线 | 亚洲| 天堂网www天堂在线资源| 在线观看片免费人成视频无码| 亚洲精品一区二区三区四区乱码| 少妇人妻综合久久中文字幕| 国产免费人成在线视频网站| 亚洲成av人片在线观看下载| 国产成人av无码精品| 国产做爰xxxⅹ高潮视频12p| 亚洲人成网站18禁止| 午夜理论片yy6080私人影院| 中文www新版资源在线| 七妺福利精品导航大全| 女人扒开屁股爽桶30分钟| 亚洲综合无码一区二区三区| 亚洲欧美另类成人综合图片| 免费国产线观看免费观看| 国产成人亚洲综合无码| 亚洲 日韩 欧美 成人 在线观看|