在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Golgin subfamily A member 2 (Golga2), partial

Recombinant Mouse Golgin subfamily A member 2 (Golga2), partial

  • 中文名稱：
    小鼠Golga2重組蛋白
  • 貨號：
    CSB-YP852845MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Golga2重組蛋白
  • 貨號：
    CSB-EP852845MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Golga2重組蛋白
  • 貨號：
    CSB-BP852845MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Golga2重組蛋白
  • 貨號：
    CSB-MP852845MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Golga2Golgin subfamily A member 2; 130 kDa cis-Golgi matrix protein; GM130
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis. Also plays a key role in spindle pole assembly and centrosome organization. Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle. Regulates the meiotic spindle pole assembly, probably via the same mechanism. Also regulates the centrosome organization. Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins.
  • 基因功能參考文獻：
    1. Deletion of GM130 in neurons causes fragmentation. PMID: 28028212
    2. Therefore, we confirmed the associations among Golgi function, fibrosis, and autophagy. Moreover, GOLGA2 knockout mice may be a potentially valuable animal model for studying autophagy-induced fibrosis. PMID: 29128360
    3. the GM130-deficient mouse provides a valuable model for investigating the etiology of human globozoospermia. PMID: 28055014
    4. In oocyte meiosis, GM130 localization and expression patterns are regulated by FMNL1. PMID: 26083584
    5. GM130 regulates microtubule organization and might cooperate with the MAPK pathway to play roles in spindle organization, migration and asymmetric division during mouse oocyte maturation PMID: 21552007

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    GOLGA2 family
  • 組織特異性：
    Detected in brain, lung, liver, thymus and pancreas. Detected in spermatocytes. Present in oocytes during all oocyte meiotic maturation (at protein level).
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 92国产精品午夜福利| 亚洲精品嫩草研究院久久| 亚洲人成网站色www| 夜夜夜夜猛噜噜噜噜噜| 野外亲子乱子伦视频丶 | 黑人玩弄出轨人妻松雪| 777精品久无码人妻蜜桃| 国产午夜aaaaa片在线影院| 免费无遮挡在线观看网站| 免费国产午夜视频在线| 亚洲第一成人网站| 免费观看全黄做爰的视频| 伊人精品一本久久综合| 99久热国产精品视频尤物| 亚洲爆乳精品无码一区二区| 国产人妻人伦精品1国产丝袜| 久久久精品久久久久久96| 国产又粗又猛又爽的视频a片| 免费观看又色又爽又湿的软件 | 久久天天躁狠狠躁夜夜av浪潮 | 好男人www社区视频在线资源| 亚洲日韩一中文字暮av| 制服丝袜中文字幕在线| 性欧美丰满熟妇xxxx性久久久 | 精品人妻伦一二三区久久aaa片| 欧美中日韩免费观看网站| 国产成人欧美综合在线影院| 国内精品九九久久久精品| 国产三级aⅴ在在线观看| 精品久久久无码中文字幕天天| 国产妇女馒头高清泬20p多毛| 午夜伦yy44880影院| 最近中文字幕mv在线视频2018 | 10000部拍拍拍免费视频| 中文字幕无码专区一va亚洲v专区在线 | 国产亚洲精品久久yy5099| 精品久久久久中文字幕app| 亚洲爆乳无码专区| 国产亚洲精品久久久久久小说| 女人高潮抽搐潮喷视频开腿| 国产98在线 | 欧美|