在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse General transcription factor II-I repeat domain-containing protein 1 (Gtf2ird1), partial

Recombinant Mouse General transcription factor II-I repeat domain-containing protein 1 (Gtf2ird1), partial

  • 中文名稱：
    小鼠Gtf2ird1重組蛋白
  • 貨號：
    CSB-YP888303MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Gtf2ird1重組蛋白
  • 貨號：
    CSB-EP888303MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Gtf2ird1重組蛋白
  • 貨號：
    CSB-EP888303MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Gtf2ird1重組蛋白
  • 貨號：
    CSB-BP888303MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Gtf2ird1重組蛋白
  • 貨號：
    CSB-MP888303MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Gtf2ird1; Ben; General transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; Binding factor for early enhancer
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.
  • 基因功能參考文獻：
    1. The mis-regulation of genes downstream of GTF2IRD1, including TbetaR2 and BMPR1b, also individually promoted mammary cancer development, and silencing of TbetaR2 suppressed GTF2IRD1-driven tumor promotion. PMID: 27239038
    2. the absence of GTF2IRD1 is associated with increased expression of genes involved in cellular proliferation, including growth factors consistent with the observed phenotype of extreme thickening of the epidermis. PMID: 27295951
    3. Gtf2ird1 is essential for Mkx transcription, while also linking mechanical forces to Mkx-mediated tendon homeostasis and regeneration. PMID: 26884464
    4. Gtf2ird1 is expressed in a number of cell types within the cochlea. Gtf2ird1 null mice showed higher auditory thresholds. PMID: 25248400
    5. findings suggest an important role for GTF2IRD1 in regulating the level and topology of rod and cone gene expression, and in maintaining normal retinal function. PMID: 25392503
    6. GTF2IRD2 has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones. PMID: 22899722
    7. This study presented that role for GTF2IRD1 in the motoric and anxiety-related abnormalities seen in Williams-Beuren syndrome, and suggests basal ganglia and potentially cerebellar abnormalities in Gtf2ird1 mice. PMID: 22652393
    8. Widespread and robust expression of Gtf2ird1 protein in the developing rodent brain, is reported. PMID: 21909369
    9. Data show the existence of a negative autoregulatory mechanism that controls the level of GTF2IRD1 transcription via direct binding of the GTF2IRD1 protein to a highly conserved region of the GTF2IRD1 promoter containing an array of three binding sites. PMID: 20007321
    10. The presence of different domains in 11 alternatively spliced isoforms of Gtf2ird1 indicates that the activity exerted by this molecule influences multiple promoters active in mouse skeletal muscle. PMID: 12780350
    11. TFII-I (Mus-TRD1) has a role in regulating immunoglobulin promoter activity PMID: 14645227
    12. First systematic and unbiased analysis of individual GTF2I-like repeats with regard to DNA binding PMID: 15987678
    13. GTF2IRD1 is a genetic determinant of mammalian craniofacial and cognitive development PMID: 16293761
    14. During development, a dynamic pattern of GTF2IRD1 expression is found predominantly in musculoskeletal tissues, the pituitary, craniofacial tissues, the eyes and tooth buds. PMID: 17239664
    15. GTF2IRD1 knockout mice showed a reduced size of the corpus callosum PMID: 17270452
    16. These transcription factors may influence fear and social behavior through the alteration of neurochemical pathways PMID: 17680805
    17. expression of TFII-I gene family were mapped in embryonic tooth germs; at bud stage, Gtf2ird1 & Gtf2ird2 were expressed in epithelial buds; at early bell stage, expression of Gtf2ird1 & Gtf2ird2 was observed in preameloblasts & preodontoblasts PMID: 17823943
    18. analysis of the consensus binding site for TFII-I family member BEN PMID: 18326499
    19. homozygous loss of Gtf2ird1 or Gtf2i results in multiple phenotypic manifestations, including embryonic lethality; brain hemorrhage; and vasculogenic, craniofacial, and neural tube defects; defects in yolk sac vasculogenesis and angiogenesis PMID: 19109438

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    TFII-I family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 久久精品国产网红主播| 亚洲女人色综合小说| 再深点灬舒服灬太大了在线视频| 国产狂喷潮在线观看| 色 亚洲 日韩 国产 综合| 亚洲国产精品国语在线| 久久九九精品国产av片国产| 久久中文字幕人妻熟女| 牛牛视频一区二区三区| 国内精品久久久久影院薰衣草| 亚洲欧洲国产综合aⅴ无码| 久久久精品94久久精品| 67194成是人免费无码| 日本三级理论久久人妻电影 | 亚洲—本道 在线无码av发| 日韩不卡1卡2卡三卡2021精品推荐 | 欧美韩中文精品有码视频在线| 国产成人亚洲精品无码青青草原| 国产三级做爰在线播放| 久久无码av三级| 夜夜精品无码一区二区三区| 国产成年无码久久久免费| 亚洲人成网站在线观看69影院 | 国产av无码国产av毛片| 欧美激情内射喷水高潮| 天天做天天爱天天要天天| 亚洲精品揄拍自拍首页一| 欧洲亚洲精品久久久久| 久久久久青草线综合超碰| 久久精品日日躁夜夜躁| 真人无码作爱免费视频| 久久精品中文闷骚内射| 麻豆成人久久精品二区三区免费 | 国产人成视频在线视频| 久久亚洲国产精品亚洲老地址| 大帝a∨无码视频在线播放| 国产国产乱老熟女视频网站97| 日本午夜免费啪视频在线| 国产av国片精品一区二区| 国产精品一区二区熟女不卡| 国产69精品久久久久777|