在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial

In Stock
  • 中文名稱:
    Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial
  • 貨號:
    CSB-MP009438MO1d9
  • 規(guī)格:
    ¥828
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • The purity of Gipr was greater than 95% as determined by SEC-HPLC
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Glucose-dependent insulinotropic polypeptide receptor
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    42.3 kDa
  • 表達(dá)區(qū)域:
    19-134aa
  • 氨基酸序列
    ETDSEGQTTTGELYQRWEHYGQECQKMLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGFVFRQCGSDGQWGSWRDHTQCENPEKNGAFQDQTLILERLQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal hFc1-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能參考文獻(xiàn):
    1. The study provides evidence that the insulinotropic action of zfGIP in mammalian systems involves activation of both the GLP-1 and the GIP receptors but not the glucagon receptor PMID: 29157578
    2. Microarray analysis revealed that pregnancy-specific glycoprotein 17 (Psg17), a potential CD9-binding partner, was significantly decreased in GIP receptor-knockout (Gipr-/-) testes. PMID: 28430907
    3. GIPR signaling in adipose tissue plays a critical role in high fat diet-induced insulin resistance and hepatic steatosis in vivo, which may involve IL-6 signaling. PMID: 28096257
    4. Genetic deletion of both GLP-1 and GIP receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose. PMID: 27020250
    5. Results suggest the beneficial effects of glucose-dependent insulinotropic polypeptide on periodontal disease. PMID: 27181102
    6. Gipr(-/-) offspring of mice exposed to high fat diet(HFD) during pregnancy/lactation became insulin resistant and obese and exhibited increased adipose tissue inflammation and decreased peripheral tissue substrate utilization after reintroduction of HFD. PMID: 26631738
    7. Beta-cell Gipr KO mice exhibit lower levels of meal-stimulated insulin secretion, decreased expansion of adipose tissue mass and preservation of insulin sensitivity and decreased TCF1 expression. PMID: 26642437
    8. Gipr is expressed in healthy arteries, predominantly in endothelial cells. PMID: 26395740
    9. These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity PMID: 25760229
    10. Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice. PMID: 25688757
    11. our data demonstrate that the expression of GLP-1R and GIPR is regulated by glucose concentrations in MC3T3-E1 cells undergoing differentiation induced by BMP-2. PMID: 24866833
    12. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
    13. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
    14. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
    15. Gipr is essential for adrenal steroidogenesis and links high fat (HF) feeding to increased levels of corticosterone, reduced glucocorticoid levels do not significantly contribute to the enhanced metabolic phenotypes in HF-fed Gipr(-/-) mice. PMID: 22043004
    16. GIPR(dn) transgenic mice show a disturbed expansion of the endocrine pancreas, due to perturbed islet neogenesis. PMID: 21818396
    17. GIP receptors play an important role in cognition, neurotransmission, and cell proliferation. PMID: 21273318
    18. Both GIPR protein and mRNA expression increased during cell differentiation, and this increase was associated with upregulation of nuclear levels of SREBP-1c and PPARgamma, as well as acetylation of histones H3/H4. PMID: 21245029
    19. GIPR(-/-) mice exhibit altered islet structure and topography and increased islet sensitivity to glucagon-like peptide-1 despite a decrease in pancreatic insulin content and gene expression PMID: 12540373
    20. Results demonstrate that glucose intolerance was additively increased during oral glucose absorption when both gastric inhibitory polypeptide receptors and glucagon-like peptide 1 receptors were inactivated. PMID: 14966573
    21. intact signaling of G-protein coupled receptors is involved in postnatal islet and beta-cell development and neogenesis of the pancreatic islets PMID: 15582721
    22. Adult GIP receptor knock-out mice exhibit a significantly lower number of newborn cells in the hippocampal dentate gyrus compared with wild-type mice. PMID: 15716418
    23. long term activation of the GIP receptor by daily treatment with N-AcGIP(LysPAL37) improved glucose tolerance due to enhancement of pancreatic beta cell glucose responsiveness and insulin secretion. PMID: 16181707
    24. Both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2. PMID: 17681422
    25. relative reduction of truncated GIPR expression may be involved in hypersensitivity of GIPR and hyperinsulinemia in diet-induced obese mice PMID: 17971513
    26. Double incretin receptor knockout mice exhibit enhanced insulin action compared with wild-type mice when fed a regular diet and are protected from high-fat diet-induced obesity and insulin resistance. PMID: 17977951
    27. Gastric inhibitory peptide receptor interacts with estrogens in the hypothalamic regulation of food intake in mice. PMID: 18505834
    28. Results suggest that activation of the gastric inhibitory polypeptide receptor can improve diabetes control in high-fat-fed mice. PMID: 19073224
    29. Analyses with GIPR-deficient mice suggest a role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush; injury of GIPR-deficient mouse sciatic nerve revealed impaired axonal regeneration. PMID: 19170165
    30. Report differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice. PMID: 19766644

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 2 family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 人妻熟女av一区二区三区 | 亚洲国产精品日韩av不卡在线| 久久精品人人槡人妻人人玩av | 国产日韩另类综合11页| 亚洲国产品综合人成综合网站| 亚洲日本在线电影| av天堂永久资源网| 国产69囗曝吞精在线视频| 国产精品主播一区二区三区| 久久婷婷五月综合色奶水99啪| 欧美饥渴熟妇高潮喷水水| 另类老妇奶性生bbwbbw| 专干熟肥老妇人视频在线看| 青青草国产精品人人爱| 成年女人毛片免费观看97| 国产产区一二三产区区别在线| 亚洲高清乱码午夜电影网| 又粗又硬又黄又爽的视频永久| 中文字幕无码家庭乱欲| 国内最真实的xxxx人伦| 无码av天天av天天爽| 国产精品亚洲二区在线播放| 亚洲综合成人av一区在线观看| 久久精品蜜芽亚洲国产av| 免费无码一区二区三区a片| 亚洲乱码av中文一区二区软件| 久久精品国产久精久精| 国产精品亚洲а∨天堂2021| 国产亚洲综合区成人国产| 99久久九九社区精品| 宅女午夜福利免费视频| 国产9 9在线 | 中文| 成人午夜电影福利免费| 国产在线视频主播区| 欧美日本国产va高清cabal| 日韩 欧美 国产 一区三| 中文字幕乱码免费专区| 精品成人av一区二区三区| 亚洲人成网77777色在线播放| 国产高清乱理伦片| 老头把我添高潮了a片|