在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Gasdermin-D (Gsdmd), partial

Recombinant Mouse Gasdermin-D (Gsdmd), partial

  • 中文名稱：
    小鼠Gsdmdc1重組蛋白
  • 貨號(hào)：
    CSB-YP866713MO1
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Gsdmdc1重組蛋白
  • 貨號(hào)：
    CSB-EP866713MO1-B
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Gsdmdc1重組蛋白
  • 貨號(hào)：
    CSB-BP866713MO1
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Gsdmdc1重組蛋白
  • 貨號(hào)：
    CSB-MP866713MO1
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Gsdmdc1
  • Uniprot No.：
  • 別名：
    Gsdmdc1; GsdmdGasdermin-D; Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D; N-terminal; GSDMD-NT); Gasdermin-D; C-terminal; GSDMD-CT)]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 表達(dá)區(qū)域：
    277-487
  • 氨基酸序列
    GIDEEELIEAADFQGLYAEVKACSSELESLEMELRQQILVNIGKILQDQPSMEALEASLGQGLCSGGQVEPLDGPAGCILECLVLDSGELVPELAAPIFYLLGALAVLSETQQQLLAKALETTVLSKQLELVKHVLEQSTPWQEQSSVSLPTVLLGDCWDEKNPTWVLLEECGLRLQVESPQVHWEPTSLIPTSALYASLFLLSSLGQKPC
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis.; Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4/CASP11 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature IL1B and triggering pyroptosis. Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity. Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes. Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation. Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine.
  • 基因功能參考文獻(xiàn)：
    1. Because DFNA5-induced secondary necrosis and GSDMD-induced pyroptosis are dependent on CASP3 activation, we propose that they are forms of programmed necrosis. PMID: 28045099
    2. the gasdermin-D pore: Executor of pyroptotic cell death PMID: 27557502
    3. Results implicate pyroptosis induced by the CASP11/4-GSDMD pathway in the pathogenesis of alcoholic hepatitis PMID: 29108122
    4. The present study not only contributes to our understanding of GSDMD recognition by inflammatory caspases but also reports a specific inhibitor for these caspases that can serve as a tool for investigating inflammasome signaling. PMID: 29891674
    5. This study reveals the pore-forming activity of GSDMD and channel-forming activity of MLKL determine different ways of plasma membrane rupture in pyroptosis and necroptosis. PMID: 27573174
    6. Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta in both canonical and non-canonical inflammasome responses. PMID: 26611636
    7. identification of gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease screens of caspase-11- and caspase-1-mediated pyroptosis in mouse bone marrow macrophages PMID: 26375003
    8. gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation PMID: 26375259
    9. This study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation. PMID: 18693275

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Gasdermin-D]: Cytoplasm, cytosol. Inflammasome.; [Gasdermin-D, N-terminal]: Cell membrane; Multi-pass membrane protein. Secreted.; [Gasdermin-D, C-terminal]: Cytoplasm, cytosol.
  • 蛋白家族：
    Gasdermin family
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 日韩人妻无码精品一专区| 极品尤物一区二区三区| 可以看三级的网站| 亚洲精品久久久久久婷婷| 韩国午夜福利片在线| 性色av无码专区一ⅴa亚洲| 中文字幕乱码熟妇五十中出色欲| 午夜在线观看免费线无码视频| 色一情一乱一伦一视频免费看| 久久综合九色综合97伊人| 伊人久久大香线蕉综合影院首页| 一个人看的免费视频www中文字幕 手机在线看永久av片免费 | 久久久精品国产sm调教网站| 色欲天天婬色婬香综合网完整版 | 影音先锋在线资源无码| 成人影院yy111111在线| 激情射精爽到偷偷c视频无码| 亚洲日韩久久综合中文字幕 | 日日碰狠狠躁久久躁9| 上司的丰满人妻中文字幕| 国产亚洲美女精品久久久| 亚洲欧美综合一区二区三区| 亚洲蜜芽在线精品一区| 牛牛视频一区二区三区| 九九九国产精品成人免费视频| 夜夜添无码试看一区二区三区| 国产顶级熟妇高潮xxxxx| 国产激情久久久久影院老熟女| 国产99在线 | 免费| 久久精品www人人做人人爽 | 伊人久久大香线蕉在观看| 欧美40老熟妇色xxxxx| 无码av免费一区二区三区| 少妇高潮流白浆在线观看| 国产乱子伦精品免费视频| 国产三级精品三级| 国产av麻豆mag剧集| 男女无遮挡猛进猛出免费观看视频| 综合色一色综合久久网| 欧美三根一起进三p| 国产成人综合久久精品推下载|