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  4. Recombinant Mouse GRB2-related adapter protein (Grap)

Recombinant Mouse GRB2-related adapter protein (Grap)

  • 中文名稱：
    小鼠Grap重組蛋白
  • 貨號：
    CSB-YP875150MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Grap重組蛋白
  • 貨號：
    CSB-EP875150MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Grap重組蛋白
  • 貨號：
    CSB-EP875150MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Grap重組蛋白
  • 貨號：
    CSB-BP875150MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Grap重組蛋白
  • 貨號：
    CSB-MP875150MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Grap
  • Uniprot No.：
  • 別名：
    Grap; GRB2-related adapter protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-217
  • 氨基酸序列
    MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK NYIRVKPHPW YSGRISRQLA EETLMKRNHL GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREASGKYFL WEEKFNSLNE LVDFYRTTTI AKRRQIFLCD EQPLIKPSRA CFAQAQFDFS AQDPSQLSLR RGDIVEVVER EDPHWWRGRA GGRLGFFPRS YVQPVHL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing.
  • 基因功能參考文獻：
    1. Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta-induced tubule injury in diabetic kidney disease. PMID: 19836472
    2. Data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway. PMID: 11971956
    3. Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome. PMID: 15174222
    4. FcgammaRIIB docking site for the SH2 domain-containing adapters Grb2 and Grap PMID: 15456754
  • 亞細胞定位：
    Membrane; Peripheral membrane protein. Cell junction, synapse.
  • 蛋白家族：
    GRB2/sem-5/DRK family
  • 組織特異性：
    Expressed in inner ear, in neruonal fibers innervating cochlear and utricular auditory hair cells (at protein level).
  • 數據庫鏈接：


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