在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Fanconi-associated nuclease 1 (Fan1), partial

In Stock
  • 中文名稱:
    小鼠Fan1重組蛋白
  • 貨號:
    CSB-EP734764MO
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    Fan1
  • Uniprot No.:
  • 別名:
    (FANCD2/FANCI-associated nuclease 1)(mFAN1)(Myotubularin-related protein 15)
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    21.4 kDa
  • 表達區域:
    893-1020aa
  • 氨基酸序列
    IHSAPAESLRAWVGEAWQAQQGRVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRRLAADFRHCRGGLPDLVVWNSQSHHCKLVEVKGPSDRLSCKQMIWLYELQKLGADVEVCHVVAVGAKSKGLG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps.
  • 基因功能參考文獻:
    1. FAN1 plays important role in protecting against somatic expansions but is either not involved in protecting against intergenerational repeat expansions or is redundant with other related enzymes. PMID: 29990673
    2. Our data show that Fan1 is involved in the physiologic response of kidney tubular cells to DNA damage, which contributes to the pathogenesis of chronic kidney disease. Moreover, Fan1(-/-) mice provide a new model with which to study the pathomechanisms of chronic kidney disease PMID: 27026368
    3. Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy PMID: 26980188
    4. ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance. PMID: 26980189
    5. Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health. PMID: 26797144

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    FAN1 family
  • 數據庫鏈接:


主站蜘蛛池模板: 奇米影视第4色| 精品国产成人高清在线观看| 极品美女扒开粉嫩小泬| 人妻中文无码久热丝袜| 成人亚洲a片v一区二区三区蜜臀| www国产成人免费观看视频| 免费国产黄网站在线观看| 欧洲熟妇性色黄| 亚洲综合色噜噜狠狠网站超清| 欧美极品色午夜在线视频| 无码人妻精品一二三区免费 | 粉嫩粉嫩的18在线观看| 伊人久久大香线蕉aⅴ色| 爱情岛论坛网亚洲品质| 使劲快高潮了国语对白在线| 成人做爰100部片免费下载| 人妻出差精油按摩被中出| 日本黄网站免费| 精品一区二区不卡无码av| 五月丁香六月激情综合在线视频| 极品少妇被弄得高潮不断| 成人无码一区二区三区网站| 欧美mv日韩mv国产网站| 欧美深性狂猛ⅹxxx深喉| 国产美女被遭强高潮网站下载| 久久好在线视频| 在线观看特色大片免费网站| 精品无码av不卡一区二区三区| 色777狠狠狠综合| 国产欧美va欧美va香蕉在线| 欧美精品国产aⅴ一区二区在线| 极品无码av国模在线观看 | 久久综合av免费观看| 国产国语老龄妇女a片| 免费看成人aa片无码视频| av边做边流奶水无码免费| 无码人妻精品一区二区三18禁| 亚洲欧美日韩中文无线码| 亚洲人成无码网www动漫| 少妇伦子伦精品无吗| 国产精品538一区二区在线|