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  4. Recombinant Mouse Extracellular sulfatase Sulf-2 (Sulf2), partial

Recombinant Mouse Extracellular sulfatase Sulf-2 (Sulf2), partial

  • 中文名稱：
    小鼠Sulf2重組蛋白
  • 貨號：
    CSB-YP806530MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Sulf2重組蛋白
  • 貨號：
    CSB-EP806530MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Sulf2重組蛋白
  • 貨號：
    CSB-EP806530MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Sulf2重組蛋白
  • 貨號：
    CSB-BP806530MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Sulf2重組蛋白
  • 貨號：
    CSB-MP806530MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Sulf2
  • Uniprot No.：
  • 別名：
    Sulf2; Extracellular sulfatase Sulf-2; mSulf-2; EC 3.1.6.-
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
  • 基因功能參考文獻：
    1. Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord PMID: 28490013
    2. sulfate 6-O-endosulfatase 2 expression in type II alveolar epithelial cells plays a protective role in epithelial injury, inflammation and mortality PMID: 28657777
    3. Sulf1 and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation. PMID: 26764203
    4. Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development. PMID: 25370455
    5. It is proposed that Sulf1, Sulf2 and ErbB1 are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system. PMID: 25448158
    6. Sulf1/, but not Sulf2/, mice, exhibited a marked delay in healing of corneal epithelial wounds. PMID: 23950901
    7. SULF2 regulates tissue regeneration in part via the activation of a novel WNT-GLI1-CYCLIN D1 pathway. PMID: 23740243
    8. Sulf1 and Sulf2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate. PMID: 22298771
    9. Heparan sulfate sulfatase SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma PMID: 22293178
    10. Sulf-1 and Sulf-2 are essential regulators of GDNF signaling in the SSC niche and direct downstream targets of Sertoli cell-specific transcriptional factor Wilm's tumor 1. PMID: 20855470
    11. SULF2 is an unexpected suppressor of atherogenic lipoprotein clearance by hepatocytes PMID: 21049473
    12. These results reveal that Sulf1 and Sulf2 fulfil non-redundant functions in vivo in the development and maintenance of the murine nervous system. PMID: 20394677
    13. results show that Sulf1 and Sulf2 play overlapping yet critical roles in mouse development and are redundant and essential for neonatal survival PMID: 17593974
    14. Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment PMID: 12368295
    15. Sulf2 may have roles in several tissues but that there is compensation by and/or redundancy with Sulf1. PMID: 17116694
    16. SULF1 is expressed in GDNF-expressing esophageal muscle and SULF2 in innervating neurons, establishing their direct functions in esophageal innervation. PMID: 17720696
    17. Results establish Sulfs 1 and 2 as essential regulators of heparan sulfate-dependent growth factor signaling in the adult muscle stem cell niche. PMID: 17920055
    18. Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 in fine-tuning rather than regulating the development of skeletal structures. PMID: 18213582
    19. has an oncogenic effect in hepatocellular carcinoma, mediated in part through up-regulation of fibroblast growth factor signaling and glypican 3 expression PMID: 18318435
    20. Sulf1 and Sulf2 are two heparan sulfate 6-O-endosulfatases that regulate the activity of multiple growth factors, such as fibroblast growth factor and Wnt, and are essential for mammalian development and survival PMID: 18687675

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  • 亞細胞定位：
    Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface.
  • 蛋白家族：
    Sulfatase family
  • 數據庫鏈接：

    KEGG: mmu:72043

    STRING: 10090.ENSMUSP00000085405

    UniGene: Mm.1011



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