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  4. Recombinant Mouse Eukaryotic translation initiation factor 2 subunit 2 (Eif2s2)

Recombinant Mouse Eukaryotic translation initiation factor 2 subunit 2 (Eif2s2)

  • 中文名稱：
    小鼠Eif2s2重組蛋白
  • 貨號：
    CSB-YP859550MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Eif2s2重組蛋白
  • 貨號：
    CSB-EP859550MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Eif2s2重組蛋白
  • 貨號：
    CSB-EP859550MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Eif2s2重組蛋白
  • 貨號：
    CSB-BP859550MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Eif2s2重組蛋白
  • 貨號：
    CSB-MP859550MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Eif2s2
  • Uniprot No.：
  • 別名：
    Eif2s2Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eIF-2-beta
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-331
  • 氨基酸序列
    SGDEMIFDP TMSKKKKKKK KPFMLDEEGD AQTEETQPSE TKEVEPEPTE EKDVDADEED SRKKDASDDL DDLNFFNQKK KKKKTKKIFD IDEAEEAIKD VKIESDAQEP AEPEDDLDIM LGNKKKKKKN VKFPEEDEIL EKDEALEDED SKKDDGISFS SQTAWAGSER DYTYEELLNR VFNIMREKNP DMVAGEKRKF VMKPPQVVRV GTKKTSFVNF TDICKLLHRQ PKHLLAFLLA ELGTSGSIDG NNQLVIKGRF QQKQIENVLR RYIKEYVTCH TCRSPDTILQ KDTRLYFLQC ETCHSRCSVA SIKTGFQAVT GKRAQLRAKA N
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
  • 基因功能參考文獻：
    1. This study provides evidence that even a mild mutation in eIF2B, leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs. PMID: 28306143
    2. BMP-2 stimulates differentiation of myoblasts into osteoblasts via the PERK-eIF2alpha-ATF4 pathway but in addition stimulates Tmem119, which itself increases ATF4 PMID: 24362451
    3. Study found that the incidence of testicular germ cell tumor in affected males was reduced 2-fold in mice that were partially deficient for Eif2s2 and embryonic lethality occurred near the time of implantation in mice that were fully deficient for Eif2s2. PMID: 19168544
  • 蛋白家族：
    EIF-2-beta/eIF-5 family
  • 數據庫鏈接：


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