在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse E3 ubiquitin-protein ligase RNF146 (Rnf146)

Recombinant Mouse E3 ubiquitin-protein ligase RNF146 (Rnf146)

  • 中文名稱：
    小鼠Rnf146重組蛋白
  • 貨號：
    CSB-YP863476MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rnf146重組蛋白
  • 貨號：
    CSB-EP863476MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rnf146重組蛋白
  • 貨號：
    CSB-EP863476MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rnf146重組蛋白
  • 貨號：
    CSB-BP863476MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rnf146重組蛋白
  • 貨號：
    CSB-MP863476MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rnf146
  • Uniprot No.：
  • 別名：
    Rnf146; E3 ubiquitin-protein ligase RNF146; EC 2.3.2.27; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-359
  • 氨基酸序列
    MEMAGCGEID HSINMLPTNK KANESCSNTA PSLTVPECAI CLQTCVHPVS LPCKHVFCYL CVKGASWLGK RCALCRQEIP EDFLDKPTLL SPEELKAASR GNGEYAWYYE GRNGWWQYDE RTSRELEDAF SKGKKNTEML IAGFLYVADL ENMVQYRRNE HGRRRKIKRD IIDIPKKGVA GLRLDCDTNT VNLARESSAD GADSGSAQTG ASVQLAVPSS TRPLTSVDGQ LTSPVTPSPD AGISLEDSFA HLQLSGDSIA ERSHRGEGEE DHESPSSGRV PDTSVEETES DASSDSEDAP VVVAQHSLTQ QRPLVPNGNQ TVADQSDRSG TDRSVAGGGT MSVNVRSRRP DGQCTVTEV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation.
  • 基因功能參考文獻：
    1. These findings indicate that RNF146 is required to coordinate beta-catenin signaling within the osteoblast lineage during embryonic and postnatal bone development PMID: 28581440
    2. RANKL represses the transcription of the E3 ubiquitin ligase RNF146 through an NF-kappaB-related inhibitory element in the RNF146 promoter. PMID: 28287403
    3. a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported. PMID: 27521426
    4. Modulation of PARP-1-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes PMID: 24842055
    5. Iduna acts as a potential antioxidant by improving mitochondrial function and inhibiting oxidative stress-induced parthanatos, and these protective effects are dependent on the involvement of ubiquitin-proteasome system. PMID: 23333241

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 組織特異性：
    Expressed at relatively high levels in the brain. Also present in spleen, heart, kidney, testis and liver. In the brain, expressed in the cerebellum, hippocampus, striatum, cortex, frontal cortex and, at lowest levels, in olfactory bulb (at protein level)
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品久久久一区二区三区| 新区乱码无人区二精东| 好硬好湿好爽好深视频| 色综合伊人丁香五月桃花婷婷| 亚洲日韩aⅴ在线视频| 日韩乱码人妻无码中文字幕视频| 国产精品久久无码不卡黑寡妇| 亚洲国产码专区| 中文字幕无码乱人伦| 无遮挡aaaaa大片免费看 | 无码人妻丰满熟妇区bbbbxxxx| 免费人妻av无码专区| 精品视频一区二区三三区四区| 国语自产精品视频在 视频| 亚洲免费观看视频| 亚洲 自拍 另类 欧美 综合| 国产影片av级毛片特别刺激| 奇米影视色777四色在线首页| 亚洲一区二区三区四区五区六区 | 中文字幕无线码中文字幕免费| 久久99精品久久久久久动态图| 老色鬼永久视频网站| 宅男色影视亚洲人在线| 久久精品国产99国产精品| 日本少妇高潮喷水视频| 亚洲中文字幕无码av正片| 国产高清不卡一区二区| 久久伊人五月丁香狠狠色| 韩国无码av片在线观看| 五 月 丁 香 综合中文| 试看120分钟做受小视频| 亚洲aⅴ无码国精品中文字慕| 国产在线看片无码人精品| 97久久综合亚洲色hezyo| 99久久久无码国产精品免费| 亚洲精品久久国产精品浴池| 亚洲最大成人av在线天堂网| 妺妺窝人体色www聚色窝仙踪| 国产成人精品久久久久精品日日| 正在播放国产乱子伦最新视频| 少妇极品熟妇人妻无码|