Recombinant Mouse DnaJ homolog subfamily B member 6 (Dnajb6)

中文名稱：

小鼠Dnajb6重組蛋白
貨號(hào)：

CSB-YP007012MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Dnajb6重組蛋白
貨號(hào)：

CSB-EP007012MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Dnajb6重組蛋白
貨號(hào)：

CSB-EP007012MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dnajb6重組蛋白
貨號(hào)：

CSB-BP007012MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Dnajb6重組蛋白
貨號(hào)：

CSB-MP007012MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dnajb6
Uniprot No.：

O54946
別名：

Dnajb6; Hsj2; MrjDnaJ homolog subfamily B member 6; Heat shock protein J2; HSJ-2; MRJ; mDj4
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-365
氨基酸序列

VDYYEVLGV QRHASPEDIK KAYRKQALKW HPDKNPENKE EAERKFKQVA EAYEVLSDAK KRDIYDKYGK EGLNGGGGGG GIHFDSPFEF GFTFRNPDDV FREFFGGRDP FSFDFFEDPF DDFFGNRRGP RGNRSRGAGS FFSTFSGFPS FGSGFPAFDT GFTPFGSLGH GGLTSFSSTS FGGSGMGNFK SISTSTKIVN GKKITTKRIV ENGQERVEVE EDGQLKSLTI NGVADENALA EECQRRGQPT PALAPGPAPA PVRVPSQARP LAPTPAPTPA PTPAPAPAQT PAPSVSTRPQ KPPRPAPTAK LGSKSNWEDD EQDRQRVPGN WDAPMTSAGL KEGGKRKKQK QKEDLKKKKS TKGNH
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
基因功能參考文獻(xiàn)：
1. Mrj(-/-) chorions at embryonic day 8.5 have expanded Rhox4b expression domains and do not form normal layers of gene expression suggesting that chorion patterning requires Mrj. PMID: 21972064
2. Data show that Mrj(-/-) embryos exhibit neural tube defects independent of the placenta phenotype, including exencephaly and thin-walled neural tubes, and suggest that Mrj plays an important role in neural stem cell self-renewal. PMID: 19777589
3. NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj PMID: 16260608
4. Study demonstrates here that, in the developing placenta of the mouse, the absence of the Mrj co-chaperone prevents proteasome degradation of keratin 18 intermediate filaments, resulting in the formation of keratin inclusion bodies. PMID: 17409114
亞細(xì)胞定位：

Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:23950

STRING: 10090.ENSMUSP00000008733

UniGene: Mm.290110