在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Deoxyribonuclease-1 (Dnase1)

Recombinant Mouse Deoxyribonuclease-1 (Dnase1)

  • 中文名稱：
    小鼠Dnase1重組蛋白
  • 貨號：
    CSB-YP007049MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Dnase1重組蛋白
  • 貨號：
    CSB-EP007049MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Dnase1重組蛋白
  • 貨號：
    CSB-EP007049MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Dnase1重組蛋白
  • 貨號：
    CSB-BP007049MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Dnase1重組蛋白
  • 貨號：
    CSB-MP007049MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Dnase1
  • Uniprot No.：
  • 別名：
    Dnase1; Dnl1Deoxyribonuclease-1; EC 3.1.21.1; Deoxyribonuclease I; DNase I
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    23-284
  • 氨基酸序列
    LRIAAFNI RTFGETKMSN ATLSVYFVKI LSRYDIAVIQ EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE QYLFVYRPDQ VSILDSYQYD DGCEPCGNDT FSREPAIVKF FSPYTEVQEF AIVPLHAAPT EAVSEIDALY DVYLDVWQKW GLEDIMFMGD FNAGCSYVTS SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG ALLQAAVVPN SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.
  • 基因功能參考文獻：
    1. DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps. PMID: 29191910
    2. HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors. PMID: 23775126
    3. Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI by transcriptional interference. PMID: 23273922
    4. silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis PMID: 22479529
    5. Data show that deletion of DNaseI hypersensitive sites does not have an obvious impact on the IgH locus or B cell development. PMID: 21085586
    6. Reduction in renal Dnase1 expression and activity is limited to mice and SLE patients with signs of membranoproliferative nephritis, and may be a critical event in the development of severe forms of lupus nephritis. PMID: 20856893
    7. A conserved sequence located 211 kilobases upstream of class II major histocompatibility complex transcriptional coactivator (CIITA) promoter III is hypersensitive to DNase I. PMID: 20363966
    8. The impact of antibodies to dsDNA, renal Dnase1 and matrix metalloprotease (MMP) mRNA levels and enzyme activities on early and late events in murine lupus nephritis, was determined. PMID: 20041189
    9. serum Dnase1 in cooperation with the plasminogen system guarantees a fast and effective breakdown of chromatin during necrosis by the combined cleavage of DNA as well as of DNA binding proteins. PMID: 15188364
    10. DNase I is essential for kidney injury induced by cisplatin PMID: 15647342
    11. Results describe chromatin disposal during necrosis and the involvement of Deoxyribonuclease 1 in this process with respect to its possible role in the prevention of anti-nuclear auto-immunity. PMID: 16352456
    12. Inhibition of Dnase1 by actin may serve as a self-protection mechanism against premature DNA degradation during cell damage. PMID: 17468836
    13. Overexpression of DNase I in cultured mouse tubular epithelial cells also induced EndoG. Both DNase I and EndoG mediate cisplatin injury to tubular epithelial cells. PMID: 17675668
    14. serum contains two nucleases, DNase1 and DNase1l3, which may substitute or cooperate with each other during DNA degradation, providing effective clearance after exposure or release from dying cells. PMID: 19154352
    15. Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis. PMID: 19246681
    16. The combined down-regulation of Dnase1 and the increased number of apoptotic cells may together be responsible for the transformation of mild mesangial lupus nephritis into severe membranoproliferative, end-stage organ disease. PMID: 19528352
    17. Data demonstrate the importance of DNase I and EndoG in host cell defense against gene and RNA delivery to renal tubular epithelial cells in vitro. PMID: 19558214

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Zymogen granule. Nucleus envelope.
  • 蛋白家族：
    DNase I family
  • 組織特異性：
    Highly expressed in the parotid and submandibular gland as well as in the kidney and duodenum (at protein level). Expressed at intermediate level in the ileum, mesenterial lymph nodes, liver, ventral prostate, epididymis, ovary and stomach (at protein lev
  • 數據庫鏈接：


主站蜘蛛池模板： 成人性做爰aaa片免费看| 欧美人与动牲交zooz| 欧美3p两根一起进高清视频| 在线观看肉片av网站免费| 人人妻人人澡人人爽| 又粗又大又硬毛片免费看| 久久综合九色综合97网| 极品少妇被猛得白浆直喷白浆小说 | а天堂中文地址在线| 精品国产免费一区二区三区香蕉| 伊在人天堂亚洲香蕉精品区| 韩国久久久久久级做爰片| 国产精品人妻在线观看| 欧美影院成年免费版| 色欲av无码一区二区人妻 | 亚洲中文字幕无码一久久区| 永久免费的av在线电影网| 亚洲欧洲日产无码中文字幕| 超碰97久久国产精品牛牛| 夜夜高潮夜夜爽高清完整版1| 色猫咪av在线观看| 亚洲欧洲自拍拍偷精品网| 国产女人抽搐喷浆视频| 国内露脸少妇精品视频| аⅴ天堂中文在线网官网| 天天爽亚洲中文字幕| 国产精品日本亚洲欧美| 午夜天堂一区人妻| 暖暖视频日本在线观看| 五月丁香六月激情综合在线视频 | 精品人妻中文无码av在线| 免费观看的av在线播放| 日韩免费人妻av无码专区蜜桃| 国产香蕉97碰碰久久人人| 国产精品xxx在线| 成人看片黄a免费看在线| 99r在线精品视频在线播放| 男女啪啪高清无遮挡免费| 丰满爆乳一区二区三区| 久久精品国产9久久综合| 情侣激情18内射骚话国产|