在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Dedicator of cytokinesis protein 8 (Dock8), partial

In Stock
  • 中文名稱:
    小鼠Dock8重組蛋白
  • 貨號(hào):
    CSB-YP807451MO1
  • 規(guī)格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Dock8
  • Uniprot No.:
  • 別名:
    Dock8Dedicator of cytokinesis protein 8
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    Yeast
  • 分子量:
    21.2kDa
  • 表達(dá)區(qū)域:
    561-730aa
  • 氨基酸序列
    RNLLYVYPQRLNFASKLASARNITIKIQFMCGEDPSNAMPVIFGKSSGPEFLQEVYTAITYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASGESLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVFNIEVQAV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
  • 基因功能參考文獻(xiàn):
    1. DOCK8 and WASp are in the same signaling pathway that links T-cell receptors (TCRs) to the actin cytoskeleton in TCR-driven actin assembly. PMID: 27599296
    2. LRCH1 as a novel effector to restrain PKCalpha-DOCK8-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE). PMID: 28028151
    3. DOCK8-deficient mice have poor control of primary cutaneous herpes simplex lesions and this is associated with increased virus loads. Furthermore, DOCK8-deficient mice showed a lack of CD4(+) T-cell infiltration into HSV-infected skin. PMID: 25776845
    4. DOCK8 expression in the haematopoietic compartment is required for protective immunity and its deficiency results in drastic reduction of RORgammat+ innate lymphoid cells in the GI tract PMID: 25091235
    5. conclude that DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function PMID: 25713392
    6. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin. PMID: 25422492
    7. DOCK8 is required for the development and survival of mature NKT cells. PMID: 23929855
    8. DOCK8 regulates interstitial DC migration by controlling Cdc42 activity spatially. PMID: 22461490
    9. Characterisation of the DOCK8-deficient mouse revealed T-cell lymphopenia, with increased T-cell turnover and decreased survival. PMID: 21969276
    10. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 T cells. PMID: 22006977
    11. Mutation of the DOCK8 protein in mice has profound effects on humoral immunity with a failure to sustain the antibody response and failure of germinal center B cell persistence. (Review) PMID: 21178273
    12. Humoral immunodeficiency due to Dock8 mutation provides evidence that organization of the immunological synapse is critical for signaling the survival of B cell subsets required for long-lasting immunity. PMID: 19898472

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    DOCK family
  • 組織特異性:
    Expressed in T cells. Expressed in bone marrow-derived dendritic cells.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产亚洲精品美女久久久久| 丰满人妻被黑人连续中出 | 亚洲中文字幕无码av永久| 色悠久久久久久久综合网伊人 | 日本在线a一区视频| 久久精品女同亚洲女同| 久久精品水蜜桃av综合天堂| 亚洲精品久久久中文字幕痴女| 亚洲一区激情校园小说| 成人做爰视频www网站| 亚洲一区二区三区乱码在线欧洲| 国内揄拍高清国内精品对白| 国内精品久久久久久久影视| 免费啪视频在线观看视频日本 | 337p日本欧洲亚洲大胆艺术图| 亚洲伊人久久大香线蕉av| 欧美精品videosex性欧美| 亚洲va中文字幕无码久久| 午夜福利不卡在线视频| 久久经精品久久精品免费观看| 性生交大片免费看女人按摩| 免费无码一区二区三区a片| 色惰日本视频网站www| 日日噜狠狠噜天天噜av| 欧洲熟妇色xxxx欧美老妇多毛网站 | 天美麻花果冻视频大全英文版| 国内精品伊人久久久久777| 久久综合97丁香色香蕉| 在线播放偷拍一区精品| 亚洲 欧美 激情 小说 另类| 无码av免费毛片一区二区| 99久久免费国产精品| 国产区精品福利在线社区| 亚洲熟妇av乱码在线观看| 日本高清熟妇老熟妇| 美女扒开腿让男人桶爽app免费看 精品国产免费人成电影在线看 | 久久国产亚洲高清观看| 久久免费的精品国产v∧| 亚洲第一无码专区天堂| 无码骚夜夜精品| 国产日韩欧美|