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  4. Recombinant Mouse DNA-binding protein inhibitor ID-4 (Id4)

Recombinant Mouse DNA-binding protein inhibitor ID-4 (Id4)

  • 中文名稱：
    小鼠Id4重組蛋白
  • 貨號：
    CSB-YP010970MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Id4重組蛋白
  • 貨號：
    CSB-EP010970MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Id4重組蛋白
  • 貨號：
    CSB-EP010970MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Id4重組蛋白
  • 貨號：
    CSB-BP010970MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Id4重組蛋白
  • 貨號：
    CSB-MP010970MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Id4; Id-4; Idb4; DNA-binding protein inhibitor ID-4; Inhibitor of DNA binding 4; Inhibitor of differentiation 4
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-161
  • 氨基酸序列
    MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP PAPPLHPAGA CPVAPPRTPL TALNTDPAGA VNKQGDSILC R
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.
  • 基因功能參考文獻：
    1. ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states PMID: 28087628
    2. results indicate that Id4 marks spermatogonial stem cells in the mouse testis. PMID: 26621350
    3. ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation. PMID: 25813983
    4. Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary PMID: 25038044
    5. ID4 promotes mammary gland development by suppressing p38MAPK activity. PMID: 22069192
    6. Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis. PMID: 21098398
    7. Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types. PMID: 20628571
    8. ID4 has a role in adipocyte differentiation and the implications of this regulation for adipose tissue formation PMID: 20460371
    9. Id4 has a unique and complex function in regulating neural stem cell proliferation and differentiation PMID: 15469968
    10. Id4 has a critical role in regulating neural precursor cell proliferation and differentiation PMID: 15882580
    11. these data support the role of Id4 as oligodendrocyte differentiation inhibitor PMID: 16862533

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：


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