在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse DNA- (apurinic or apyrimidinic site) lyase 2 (Apex2)

Recombinant Mouse DNA- (apurinic or apyrimidinic site) lyase 2 (Apex2)

  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-YP727875MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-EP727875MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-EP727875MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-BP727875MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-MP727875MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Apex2; Ape2DNA-(apurinic or apyrimidinic site) lyase 2; EC 3.1.-.-; EC 4.2.99.18; APEX nuclease 2; Apurinic-apyrimidinic endonuclease 2; AP endonuclease 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-516
  • 氨基酸序列
    MLRVVSWNIN GIRSPLQGLA CQEPSSCPTA LRRVLDELDA DIVCLQETKV TRDVLTEPLA IVEGYNSYFS FSRSRSGYSG VATFCKDSAT PVAAEEGLSG VFATLNGDIG CYGNMDEFTQ EELRVLDSEG RALLTQHKIR TLEGKEKTLT LINVYCPHAD PGKPERLTFK MRFYRLLQMR AEALLAAGSH VIILGDLNTA HRPIDHCDAS SLECFEEDPG RKWMDGLLSN PGDEAGPHIG LFMDSYRYLH PKQQRAFTCW SVVSGARHLN YGSRLDYVLG DRALVIDTFQ ASFLLPEVMG SDHCPVGAVL NVSCVPAKQC PALCTRFLPE FAGTQLKILR FLVPLEQEPV REQQVLQPSH QIQAQRQPRK ACMHSTRLRK SQGGPKRKQK NLMSYFQPSS SLSQTSGVEL PTLPLVGPLT TPKTAEEVAT ATVLEEKNKV PESKDEKGER TAFWKSMLSG PSPMPLCGGH REPCVMRTVK KTGPNFGRQF YMCARPRGPP SDPSSRCNFF LWSRPS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
  • 基因功能參考文獻：
    1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis. PMID: 25158232
    2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (AID)-independent damage. PMID: 24935922
    3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 and up-regulation of APE2 expression in germinal center B cells. PMID: 24927551
    4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte transition, due to a p53-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1. PMID: 21228350
    5. may participate in postreplicative base excision repair PMID: 12573260
    6. APEX2 is required for proper cell cycle progression of proliferating lymphocytes. PMID: 15319281
    7. Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination. PMID: 18025127
    8. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair. PMID: 18585982
    9. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes. PMID: 19556307

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Mitochondrion. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
  • 蛋白家族：
    DNA repair enzymes AP/ExoA family
  • 組織特異性：
    Expressed in lymphocytes, thymocytes and splenocytes (at protein level). Highly expressed in the thymus and weakly expressed in the bone marrow, spleen, eye, kidney, lung, brain and uterus.
  • 數據庫鏈接：


主站蜘蛛池模板： 久久天天躁狠狠躁夜夜躁2014| 欧美性白人极品1819hd| 婷婷丁香五月中文字幕| 妺妺窝人体色www在线| 日韩av一国产av一中文字慕| 精品少妇无码一区二区三批 | 欧美性猛交aaaa片黑人| 亚洲的天堂av无码| 久久精品国产一区二区三区| 夜夜澡人摸人人添人人看| 亚洲aⅴ天堂av天堂无码| 久久www免费人成一看片 | 国产理论剧情大片在线播放| 国产精品久久久久久久久久直播 | 又爆又大又粗又硬又黄的a片 | 国产人妻一区二区三区四区五区六| 少妇饥渴xxhd麻豆xxhd骆驼| 忘忧草日本在线www| 欧美日韩国产中文高清视频| 日本精品人妻无码免费大全| 日本japanese丰满白浆| 日本妇人成熟免费中文字幕| 乱人伦中文无码视频| 欧美成人精品三级网站| 亚洲高清国产拍精品网络战| 色欲天天天无码视频| 欧美大片aaaaa免费观看| 色偷偷色噜噜狠狠成人免费视频| 色爱情人网站| 欧美性生交xxxxx无码久久久| 国产成人高清精品亚洲| 一本一本久久aa综合精品| 免费女人裸体视频无遮挡免费网站| 丁香五月网久久综合| 三上悠亚ssⅰn939无码播放| 浮妇高潮喷白浆视频| 亚洲中文有码字幕日本| 国产亚洲美女精品久久久2020| 精品黑人一区二区三区| 日韩午夜理论免费tv影院| 老熟妇性老熟妇性色|