在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse DNA- (apurinic or apyrimidinic site) lyase 2 (Apex2)

Recombinant Mouse DNA- (apurinic or apyrimidinic site) lyase 2 (Apex2)

  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-YP727875MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-EP727875MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-EP727875MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-BP727875MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse DNA-(apurinic or apyrimidinic site) lyase 2(Apex2)
  • 貨號：
    CSB-MP727875MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Apex2; Ape2DNA-(apurinic or apyrimidinic site) lyase 2; EC 3.1.-.-; EC 4.2.99.18; APEX nuclease 2; Apurinic-apyrimidinic endonuclease 2; AP endonuclease 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-516
  • 氨基酸序列
    MLRVVSWNIN GIRSPLQGLA CQEPSSCPTA LRRVLDELDA DIVCLQETKV TRDVLTEPLA IVEGYNSYFS FSRSRSGYSG VATFCKDSAT PVAAEEGLSG VFATLNGDIG CYGNMDEFTQ EELRVLDSEG RALLTQHKIR TLEGKEKTLT LINVYCPHAD PGKPERLTFK MRFYRLLQMR AEALLAAGSH VIILGDLNTA HRPIDHCDAS SLECFEEDPG RKWMDGLLSN PGDEAGPHIG LFMDSYRYLH PKQQRAFTCW SVVSGARHLN YGSRLDYVLG DRALVIDTFQ ASFLLPEVMG SDHCPVGAVL NVSCVPAKQC PALCTRFLPE FAGTQLKILR FLVPLEQEPV REQQVLQPSH QIQAQRQPRK ACMHSTRLRK SQGGPKRKQK NLMSYFQPSS SLSQTSGVEL PTLPLVGPLT TPKTAEEVAT ATVLEEKNKV PESKDEKGER TAFWKSMLSG PSPMPLCGGH REPCVMRTVK KTGPNFGRQF YMCARPRGPP SDPSSRCNFF LWSRPS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
  • 基因功能參考文獻：
    1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis. PMID: 25158232
    2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (AID)-independent damage. PMID: 24935922
    3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 and up-regulation of APE2 expression in germinal center B cells. PMID: 24927551
    4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte transition, due to a p53-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1. PMID: 21228350
    5. may participate in postreplicative base excision repair PMID: 12573260
    6. APEX2 is required for proper cell cycle progression of proliferating lymphocytes. PMID: 15319281
    7. Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination. PMID: 18025127
    8. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair. PMID: 18585982
    9. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes. PMID: 19556307

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Mitochondrion. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
  • 蛋白家族：
    DNA repair enzymes AP/ExoA family
  • 組織特異性：
    Expressed in lymphocytes, thymocytes and splenocytes (at protein level). Highly expressed in the thymus and weakly expressed in the bone marrow, spleen, eye, kidney, lung, brain and uterus.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲 综合 校园 欧美 制服| 俺去俺来也在线www色官网| 成人毛片100免费观看| 国产日韩在线时看高清视频| 国产免费观看黄av片| 中文字幕在线亚洲日韩6页| 久久久橹橹橹久久久久| 人妻丰满熟妇岳av无码区hd| 国产sm主人调教女m视频| 国产精品久久国产精品99盘| 久久综合九色综合欧洲98| 亚洲熟女少妇一区二区| 欧美性生交大片免费看| 国产亚洲欧洲日韩在线...| 国产日产欧产美韩系列影片| 18禁黄网站禁片免费观看| 欧美熟妇性开放| 久久精品人人槡人妻人人玩av | 亚洲欧美日韩二三区在线| a欧美爰片久久毛片a片| 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 成年性午夜无码免费视频| 五月天天天综合精品无码| 领导边摸边吃奶边做爽在线观看| 国产精品成人久久久久久久| 中文字幕av无码不卡免费| 大香伊人久久精品一区二区| 小sao货水好多真紧h视频| 内射巨臀欧美在线视频| 久久青青草原精品国产app| 色噜噜狠狠色综合av| 伊人色综合一区二区三区| 久久www成人_看片免费不卡| 337p日本欧洲亚洲大胆艺术图| 18级成人毛片免费观看| 国产免费mv大片人人电影播放器| 中文字幕乱码一区av久久| 成人a片产无码免费视频在线观看| 人妻少妇av中文字幕乱码| 日日狠狠久久8888偷偷色| 国产精品96久久久久久av网址|