在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse DEP domain-containing mTOR-interacting protein (Deptor)

  • 中文名稱:
    Recombinant Mouse DEP domain-containing mTOR-interacting protein(Deptor)
  • 貨號:
    CSB-YP687983MO
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse DEP domain-containing mTOR-interacting protein(Deptor)
  • 貨號:
    CSB-EP687983MO
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mouse DEP domain-containing mTOR-interacting protein(Deptor)
  • 貨號:
    CSB-EP687983MO-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse DEP domain-containing mTOR-interacting protein(Deptor)
  • 貨號:
    CSB-BP687983MO
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse DEP domain-containing mTOR-interacting protein(Deptor)
  • 貨號:
    CSB-MP687983MO
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Deptor; Depdc6; Kiaa4200; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-409
  • 氨基酸序列
    MEEGSSGGSG SSDSNAGGSG GVQQRELERM AEVLVTGEQL RLRLHEEKVI KDRRHHLKTY PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH VCDEHKEFKD VKLFYRFRKD DGTFALDSEV KAFMRGQRLY EKLMSPETTL LQPREEEGVK YERTFMASEF LDWLVQEGEA TTRKEAEQLC HRLMDHGIIQ HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNETSPSSQE THDSPFCLRK QSHDSRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC HIQAVDPSGP AAAAGMKVCQ FVVSVNGLNV LNVDYRTVSN LILTGPRTIV MEVMEELDC
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
  • 基因功能參考文獻:
    1. Hepatic DEPTOR accelerates the inhibition of mTORC1 during the transition to fasting to adjust metabolism to the nutritional status. PMID: 28462079
    2. Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease. PMID: 27224922
    3. These results support the idea that other neuronal populations are responsible for these phenotypes. Nonetheless, we observed a mild elevation in fasting blood glucose, insulin resistance, and alterations in liver glucose and lipid homeostasis in mice overexpressing DEPTOR in POMC neurons. Taken together, these results show that DEPTOR overexpression in POMC neurons does not affect energy balance regulation but could modu PMID: 27097662
    4. The present study indicates that regulation of DEPTOR/mTOR signaling may be an important mechanism for glutamine in prevention against the development of colitis-associated colorectal cancer (CAC): the chemopreventive effect of dietary glutamine on CAC is, at least in part, associated with the induction of autophagy. PMID: 27144580
    5. DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65. PMID: 27179948
    6. p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation. PMID: 26795633
    7. DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells PMID: 25258312
    8. DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis. PMID: 22883231
    9. Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR kinase substrates, 4E-BP1 and S6K1, and concomitantly increased protein synthesis. PMID: 21607293

    顯示更多

    收起更多

  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产成人三级在线视频网站观看 | 日本免费人成视频播放| 国产精品最新免费视频| 中文字幕 欧美精品 第1页| 中国精学生妹品射精久久| 色一情一乱一伦| 亚洲精品国产av天美传媒| 免费能直接看黄的视频| 色婷婷av一区二区三区浪潮| 欧美性xxxxx极品老少| 精品一卡二卡三卡| 在线观看免费人成视频网| 国产成人精选在线观看不卡| 欧美人与动牲交a精品| 娇妻被黑人粗大高潮白浆| 中国精品无码免费专区午夜 | 亚洲一区二区三区播放| 成人区人妻精品一区二区不卡视频 | 亚洲人成影院在线观看| 亚洲国产精品一区二区久久| 亚洲人成人一区二区三区| 欧美18videosex性欧美黑吊| 精品久久久久久久久久中文字幕| 亚洲va无码va在线va天堂| 亚州性无码不卡免费视频| 风流少妇又紧又爽又丰满| 四虎影视久久久免费观看| 国产精品特黄aaaa片在线观看 | 日本少妇三级hd激情在线观看 | 77777亚洲午夜久久多喷| 好男人社区影院www| 337p粉嫩大胆噜噜噜| 无码少妇一区二区浪潮免费| 国产精品卡一卡2卡3卡4| 国产真实乱人偷精品人妻| 久久久亚洲欧洲日产国码606| 欧美大胆作爱视频欣赏人体| 中文字幕乱码熟女人妻水蜜桃| 隔壁老王国产在线精品| 成人性欧美丨区二区三区| 人妻丰满熟妇av无码区app|