在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Cytoplasmic dynein 1 heavy chain 1 (Dync1h1), partial

Recombinant Mouse Cytoplasmic dynein 1 heavy chain 1 (Dync1h1), partial

  • 中文名稱：
    小鼠Dync1h1重組蛋白
  • 貨號：
    CSB-YP888299MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Dync1h1重組蛋白
  • 貨號：
    CSB-EP888299MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Dync1h1重組蛋白
  • 貨號：
    CSB-EP888299MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Dync1h1重組蛋白
  • 貨號：
    CSB-BP888299MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Dync1h1重組蛋白
  • 貨號：
    CSB-MP888299MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Dync1h1
  • Uniprot No.：
  • 別名：
    Dync1h1; Dhc1; Dnch1; Dnchc1; DyhcCytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain; cytosolic
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression.
  • 基因功能參考文獻：
    1. demonstrate that the outward transport of dynein from soma to axon terminal is driven by direct interactions with the anterograde motor kinesin-1. PMID: 27210554
    2. The Swl/Swl mutation of Dync1h1 gene led to embryonic mal-development and lethality, whereas the Swl/+ DRG neurons demonstrated deficient retrograde transport in dynein-driven cargos and excessive apoptosis during mid- to late-developmental stages. PMID: 27080913
    3. The Loa heterozygote phenotype is morphometrically depleted; in addition to dendritic axonal defects, the Loa mutation in a mouse model for mixed motor-sensory loss considers the entire neuraxis and is not a model for sensory loss. PMID: 22684941
    4. Data show that amyloid precursor protein (APP) levels are well-correlated with the amount of the light chain of kinesin-1 (KLC1). PMID: 22582169
    5. neuromuscular junction defects in mice with mutation of dynein heavy chain 1 PMID: 21346813
    6. Results provide genetic evidence that dynein plays a key role in lipid metabolism and thermogenesis. PMID: 20887786
    7. These results suggest a potential role for the dynein tail in motor function, and provide direct evidence for a link between single-motor processivity and disease. PMID: 21102439
    8. results show that missense point mutations result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, resembling key features of human pathology PMID: 12730604
    9. Results describe the gene encoding the dynein axonemal light intermediate chain Dnali1, and suggest that the C-terminal part of the cytoplasmic dynein heavy chain 1 is a putative interacting polypeptide of Dnali1. PMID: 16496424
    10. This study provide in vivo evidence that distinct mutations in cytoplasmic dynein can either result in a pure sensory neuropathy or in a sensory neuropathy with motor neuron involvement. PMID: 18160659
    11. A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function. PMID: 18373888
    12. Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease. PMID: 18952079

    顯示更多

    收起更多

  • 相關疾病：
    Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons.
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Dynein heavy chain family
  • 數據庫鏈接：


主站蜘蛛池模板： 红桃av一区二区三区在线无码av| 67194熟妇在线观看线路1| 成人永久免费网站在线观看 | 中文字幕无码热在线视频| 欧美黑人激情性久久| 中文字幕亚洲欧美日韩在线不卡| а√天堂资源官网在线资源| 日本两人免费观看的视频| 国产做a爰片久久毛片a片美国 | 国产乡下妇女做爰| 久久97国产超碰青草| 亚洲成αv人片在线观看| 国产公开免费人成视频| 97久久精品无码一区二区天美| 亚洲综合激情另类小说区| 六月丁香亚洲综合在线视频| 少妇高潮太爽了在线视频| 全黄性性激高免费视频| 84pao国产成视频永久免费| 无码国产精成人午夜视频| 中文字幕人妻互换av久久| 又黄又爽又猛的视频免费| 久久亚洲国产精品123区| 潮喷大喷水系列无码| 97久久精品亚洲中文字幕无码| 中文字幕久久综合伊人| 狂野欧美激情性xxxx在线观看 | 一个人看的视频www在线| 女人扒开屁股桶爽30分钟| 国产亚洲精品久久久久久久软件 | 天天做天天大爽天天爱| 日韩做a爰片久久毛片a片| 综合亚洲伊人午夜网| 无码国产乱人伦偷精品视频| 成人爽a毛片免费看| 免费的av网站手机版| 成人性生交片无码免费看| 纯肉无遮挡无码日本动漫| 99热成人精品热久久| 久久精品一区二区三区四区| 美女把尿囗扒开让男人添|