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  4. Recombinant Mouse Cytochrome P450 1B1 (Cyp1b1)

Recombinant Mouse Cytochrome P450 1B1 (Cyp1b1)

  • 中文名稱：
    Recombinant Mouse Cytochrome P450 1B1(Cyp1b1)
  • 貨號：
    CSB-YP720672MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytochrome P450 1B1(Cyp1b1)
  • 貨號：
    CSB-EP720672MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytochrome P450 1B1(Cyp1b1)
  • 貨號：
    CSB-EP720672MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytochrome P450 1B1(Cyp1b1)
  • 貨號：
    CSB-BP720672MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytochrome P450 1B1(Cyp1b1)
  • 貨號：
    CSB-MP720672MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cyp1b1; Cyp1-b1Cytochrome P450 1B1; EC 1.14.14.1; CYPIB1; Cytochrome P450CMEF; Cytochrome P450EF; Hydroperoxy icosatetraenoate dehydratase; EC 4.2.1.152
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-543
  • 氨基酸序列
    MATSLSADSP QQLSSLSTQQ TTLLLLFSVL AAVHLGQWLL RQWQRKPWSS PPGPFPWPLI GNAAAVGQAS HLYFARLARR YGDVFQIRLG SCPVVVLNGE SAIHQALVQQ GSIFADRPPF ASFRVVSGGR SLAFGHYSEH WKTQRRSAYS TMRAFSTRHP RSRGLLEGHA LAEARELVAV LVRRCAGGAF LDPTQPVIVA VANVMSAVCF GCRYNHDDAE FLELLSHNEE FGRTVGAGSL VDVLPWLQLF PNPVRTTFRK FEQLNRNFSN FVLDKFLRHR ESLVPGAAPR DMTDAFILSA EKKASGAPGD DSSGLDLEDV PATITDIFGA SQDTLSTALL WLLILFTRYP DVQARVQAEL DQVVGRDRLP CMSDQPNLPY VMAFLYESMR FSSFLPVTIP HATTANTFVL GYYIPKNTVV FVNQWSVNHD PAKWPNPEDF DPARFLDKDG FINKALASSV MIFSVGKRRC IGEELSKMLL FLFISILAHQ CNFKANQNES SNMSFSYGLT IKPKSFRIHV SLRESMELLD NAVKKLQTEE GCK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2. Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites. May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system. Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2. Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products. Plays an important role in retinal vascular development. Under ambient/hyperoxic O2 conditions, promotes angiogenesis and capillary morphogenesis of retinal endothelial cells and pericytes, likely by metabolizing the oxygenated products symptomatic of oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
  • 基因功能參考文獻：
    1. Hepc decreases in Cyp1b1-/- and gestational vitamin A deficiency mice resulted in stellate activation and lipogenesis suppression. PMID: 28583802
    2. Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, the study tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. hCYP1B1 genotype did not impact lung tumor multiplicity, but tended to enhance incidence compared to Cyp1b1 wild-type mice (P = 0.07). PMID: 26990437
    3. CYP1B1 contributed to the development of Ang II-induced abdominal aortic aneurysm and associated pathogenic events in mice, likely by enhancing oxidative stress and associated signaling events PMID: 27301358
    4. Miroestrol suppressed beta-naphthoflavone increases in CYP1B1. PMID: 26893163
    5. Findings provide evidence that CYP1B1 is directly involved in the development of cardiac hypertrophy. PMID: 28251434
    6. Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha and PPARalpha. PMID: 27036855
    7. hypertension, and associated pathogenesis in ApoE(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids. PMID: 26573711
    8. Follicle stimulating hormone functions via p38 MAPK-induced dephosphorylation at Ser(727) of STAT1 to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles. PMID: 25315223
    9. Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice. PMID: 25870196
    10. Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II-induced hypertension. PMID: 25694484
    11. Data indicaate that adduct formation in cytochrome P450 Cyp1b1 knockout mice was significantly reduced compared to wild-type mice receiving dibenzo[def,p]chrysene (DBC). PMID: 25868132
    12. Cyp1b1 deletion substantially alters the expression of genes associated with fatty acid homeostasis PMID: 25703193
    13. Data indicate that hepatic stearoyl-CoA desaturase 1 (SCD1) expression was decreased in cytochrome P450 1B1 (CYP1B1)-null mice. PMID: 24684199
    14. Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38alpha-deficient and MSK1/2 double knockout mice, we show here that TNF-alpha potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade PMID: 25233930
    15. a direct role for mitochondrial CYP1B1 in PAH-mediated oxidative and chemical damage to mitochondria. PMID: 24497629
    16. Cyp1B1 expression in vascular cells plays an important role in the regulation of the cellular reductive state, thrombospondin (TSP)2 expression, and NF-kappaB activation. PMID: 24088896
    17. Metabolic activity of CYP1B1 contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of Postn expression. PMID: 23979599
    18. In the present study we show that [a] NQO1 protein locates to cytosol, ER and mitochondria. PMID: 23692925
    19. important role for Cyp1B1 expression in the regulation of pericyte proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappaB expression and/or activity PMID: 23568032
    20. Dexamethasone in combination with methylisobutylxanthine (DM) induces Cyp1b1 and a 6.7 kb mouse Cyp1b1 promoter-luciferase reporter in each cell type prior to adipogenesis. An 18 base sequence (at -6.11 kb) (PaxE) which was essential for this reporter stimulation in 3T3-L1 cells bound the transcription factor Pax6. PMID: 23376040
    21. in DOCA-salt hypertension in mice, cytochrome P450 1B1 plays a pivotal role in cardiovascular dysfunction, renal damage, and inflammation, and increased levels of catecholamines, vasopressin, and endothelin-1 PMID: 23108654
    22. CYP1B1-mediated estrogen metabolism promotes the development of pulmonary arterial hypertension, likely via the formation of mitogens, including 16alpha-hydroxyestrone. PMID: 22859684
    23. Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice. PMID: 22184325
    24. The results indicate that downregulation of testicular CYP1B1 by estradiol was independent of PKA activity and was not mediated by estrogen receptors in MA-10 cells. PMID: 21785971
    25. results identify protein kinase A as the major signaling pathway involved in the LH-mediated regulation of testicular CYP1B1 expression in Leydig tumor cells PMID: 21389345
    26. CYP1B1 gene plays an important role in the development of the anterior chamber angle. Deletion of this gene leads to abnormalities in the trabecular meshwork. PMID: 18953896
    27. Data suggest that cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiological changes. PMID: 20805442
    28. CYP1B1 and eNOS cooperate in different ways to lower oxidative stress and thereby to promote capillary morphogenesis in vitro and angiogenesis in vivo. PMID: 20032512
    29. CYP1A1 polymorphisms probably predispose to an earlier onset of breast cancer and might be associated with higher c-erbB-2 protein level, but further studies on a much larger group are required to substantiate our findings. PMID: 20088394
    30. CYP1B1-deficient mice exhibit abnormalities in their ocular drainage structure and trabecular meshwork that are similar to those reported in human PCG patients [review] PMID: 17914928
    31. Cyp1b1 bioactivation of dibenzo(a,1)pyrene occurs in fetal target tissues, following transplacental exposure, with the thymus and lung as primary and secondary targets, respectively. PMID: 19138945
    32. In the developing mouse embryo Cyp1b1 exhibits asymmetric expression along the axes of development. PMID: 15359218

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion.
  • 蛋白家族：
    Cytochrome P450 family
  • 組織特異性：
    Constitutively expressed in retinal and kidney pericytes cells. Expressed in retinal endothelial cells (at protein level). Expressed in cardiac, pulmonary and aortic endothelial cells. Constitutively expressed in trabecular meshwork of the eye (at protein
  • 數據庫鏈接：


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