在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Cyclin-dependent kinase 7 (Cdk7)

Recombinant Mouse Cyclin-dependent kinase 7 (Cdk7)

  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinase 7(Cdk7)
  • 貨號：
    CSB-YP005075MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinase 7(Cdk7)
  • 貨號：
    CSB-EP005075MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinase 7(Cdk7)
  • 貨號：
    CSB-EP005075MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinase 7(Cdk7)
  • 貨號：
    CSB-BP005075MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinase 7(Cdk7)
  • 貨號：
    CSB-MP005075MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cdk7; Cak; Cdkn7; Crk4; Mo15; Mpk-7Cyclin-dependent kinase 7; EC 2.7.11.22; EC 2.7.11.23; 39 kDa protein kinase; P39 Mo15; CDK-activating kinase; CR4 protein kinase; CRK4; Cell division protein kinase 7; Protein-tyrosine kinase MPK-7; TFIIH basal transcription factor complex kinase subunit
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-346
  • 氨基酸序列
    AVDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM CSLPDYVTFK SFPGVPLQHI FIAAGDDLLE LIQGLFLFNP CTRTTASQAL KTKYFSNRPG PTPGCQLPRP NCPVEALKEP ANPTVATKRK RAEALEQGIL PKKLIF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
  • 基因功能參考文獻：
    1. the cyclin-dependent kinase CDK7 is regulated by miR-210 and is necessary for normal NP cell-cycle progression. Our findings demonstrate that miRNAs are essential for normal NP proliferation and cell-cycle progress during neocortical development PMID: 27411104
    2. Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis. PMID: 27693251
    3. Whereas Cdk7 was completely dispensable for global transcription, it was essential for the cell cycle via phosphorylation of Cdk1 and Cdk2. In vivo, Cdk7 was indispensable for cell proliferation except during the first stages of embryonic development. PMID: 22505032
    4. investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells PMID: 20231280
    5. Cdk7 kinase activity and cell cycle kinetics were found to be comparable in wild-type and Hint(-/-) mouse embryonic fibroblasts, suggesting that Hint may not be a key regulator of Cdk7 activity PMID: 12748294
    6. results demonstrate that the Cdk7 submodule of transcription factor IIH acts as a physiological roadblock to adipogenesis by inhibiting PPARgamma activity PMID: 18981214
    7. Inhibition of SF-1-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1. PMID: 19015234

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 国产鲁鲁视频在线观看| 欧美亚洲色欲色一欲www| 亚洲精品无码成人av电影网| 国产亚洲精品久久久久的角色| 日本熟妇人妻中出| 久久男人av资源站| 另类亚洲小说图片综合区| 无码av永久免费专区麻豆| 久人人爽人人爽人人片av| 又粗又硬整进去好爽视频| 日本欧美一区二区三区高清| 真正免费毛片在线播放| 极品少妇被啪到呻吟喷水| 亚洲国产成人精品一区刚刚| 日本工口里番无遮█彩色| 最新亚洲人成无码网站| 亚洲精品国产一区二区贰佰信息网| 色婷婷六月亚洲婷婷丁香| 插插插精品亚洲一区| 国产又粗又猛又爽又黄| 邻居少妇张开腿让我爽了在线观看| 热久久美女精品天天吊色| 国产亚洲香蕉线播放αv38| 大伊香蕉精品视频在线直播| 日日噜噜夜夜狠狠va视频v| 在线播放国产精品三级网| 无码av不卡免费播放| 国产内射爽爽大片| 人人妻人人澡人人爽人人dvd| 182tv午夜福利在线地址二| 亚洲国产一成人久久精品| 老熟妇性老熟妇性色| 色拍拍在线精品视频| 亚洲综合久久无码色噜噜赖水| 熟女人妻av完整一区二区三区| 少妇无码吹潮| 野花社区在线www日本| 精品国产中文字幕在线视频| 亚洲aⅴ男人的天堂在线观看| 日本丰满少妇xxxx| 蜜臀av国产精品久久久久|