在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Cubilin (Cubn), partial

Recombinant Mouse Cubilin (Cubn), partial

  • 中文名稱：
    Recombinant Mouse Cubilin(Cubn) ,partial
  • 貨號：
    CSB-YP884949MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cubilin(Cubn) ,partial
  • 貨號：
    CSB-EP884949MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cubilin(Cubn) ,partial
  • 貨號：
    CSB-EP884949MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cubilin(Cubn) ,partial
  • 貨號：
    CSB-BP884949MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cubilin(Cubn) ,partial
  • 貨號：
    CSB-MP884949MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cubn
  • Uniprot No.：
  • 別名：
    Cubn; Ifcr; Cubilin; Intrinsic factor-cobalamin receptor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
  • 基因功能參考文獻：
    1. Cubilin is involved in 25(OH) vitamin D uptake by adipocytes. PMID: 29186386
    2. In adult mouse testes, strong Cubn immunoreactivity was found in the elongating spermatids. In Sertoli cells and peritubular cells, Cubn immunoreactivity was weak throughout the testis development. In the inter-stitium, Cubn immunoreactivity was found in foetal Leydig cells, was weak to negligible in the stem cells and progenitor Leydig cells and was strong in immature and adult Leydig cells. PMID: 26148765
    3. Cubilin deficiency reduces renal salvage and delivery back to the blood of albumin and apolipoprotein (apo)A-I, which decreases blood levels of albumin and apoA-I/HD PMID: 24357674
    4. cubilin and megalin mRNA expression is under epigenetic control PMID: 23773363
    5. plasma membrane binding of Fgf8, and most likely of the Fgf8 family members Fgf17 and Fgf18, to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity. PMID: 23592779
    6. Impaired protein endocytosis caused by invalidation of ClC-5 primarily reflects a trafficking defect of megalin and cubilin in PTC. PMID: 12815097
    7. Cubilin expression is pronounced in the extraembryonic visceral endoderm of embryos. Cubilin, is also expressed by a subpopulation of cells dispersed within the embryonic endoderm having a migratory morphology. PMID: 14983511
    8. Amn is an essential component of the Cubn receptor complex PMID: 15342463
    9. Cubilin is required for embryonic development and is essential for the formation of somites, and definitive endoderm. PMID: 16787536

    顯示更多

    收起更多

  • 亞細胞定位：
    Apical cell membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, coated pit. Endosome. Lysosome membrane; Peripheral membrane protein.
  • 組織特異性：
    Expressed in kidney, thymus, ileum, placenta, small intestine and yolk sac. In kidney expressed on the apical brush border surface of proximal tubular cells, in particular in endosomes and recycling membranes vesicles, so-called dense apical tubules, whic
  • 數據庫鏈接：


主站蜘蛛池模板： 人妻少妇无码精品视频区| 欧美成人午夜免费全部完| 日本不卡一区二区三区在线| 三上悠亚精品一区二区久久| 少妇的丰满3中文字幕| 久久久综合九色综合鬼色| 1313午夜精品理论片| 萝卜视频高清免费视频日本| 久久久久久亚洲精品不卡| 国产亚洲精品aaaa片小说| 在线中文字幕乱码英文字幕正常| 国产精品白丝久久av网站| 成年女人片免费视频播放a| 人人妻人人澡av天堂香蕉| 中文字幕人妻中文av不卡专区| 午夜理论片yy8860y影院| 色v99在线影院| 18禁黄网站禁片免费观看女女| 国产aⅴ夜夜欢一区二区三区| 亚洲一区二区三区影院| 少妇把腿扒开让我爽爽视频| 国产素人在线观看人成视频| 亚洲手机在线人成网站| 色诱视频在线观看| 国产日韩精品中文字无码| 成人免费视频在线观看| 一区二区狠狠色丁香久久婷婷| 久久人人97超碰国产公开| 97碰碰碰人妻无码视频| 美女张开腿黄网站免费下载| 欧美日韩亚洲tv不卡久久| 97免费人妻在线视频| 无码熟妇αⅴ人妻又粗又大| 精品人伦一区二区三区潘金莲 | 午夜福利理论片在线观看播放| 人人妻人人澡人人爽欧美一区九九 | 精品国产自在现线看久久| 亚洲国产精品久久精品| 毛片tv网站无套内射tv网站| 亚洲成av人在线观看天堂无码| 亚洲综合成人av一区在线观看|