在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Crumbs homolog 1 (Crb1), partial

Recombinant Mouse Crumbs homolog 1 (Crb1), partial

  • 中文名稱：
    Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
  • 貨號：
    CSB-YP855357MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
  • 貨號：
    CSB-EP855357MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
  • 貨號：
    CSB-EP855357MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
  • 貨號：
    CSB-BP855357MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
  • 貨號：
    CSB-MP855357MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Crb1; Protein crumbs homolog 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.; May play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization.
  • 基因功能參考文獻(xiàn)：
    1. This study showed that The geographic distribution of subretinal microglia/macrophages changes with age in both Crb1 rd8/rd8 and C57BL mice, but the total number of microglia only increases in Crb1 rd8/rd8 mice,and pro-inflamatory phenotype. PMID: 25588310
    2. The retinal phenotype of Grk1-/- mice is compromised by a Crb1 rd8 mutation. PMID: 26664249
    3. Presence of rd8 (Crb1) mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model carrying the Ctrp5 mutation. PMID: 25814825
    4. Results show that Crb1rd8/rd8 mutation is necessary, but not sufficient for the development of all the degenerative features. PMID: 25147295
    5. Study showed that CRB1 and CRB2 in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 influences the severity of the murine Crb1-linked retinal dystrophies. PMID: 24565864
    6. These findings suggest that CRB1 and CRB2 suppress late progenitor pool expansion by regulating multiple proliferative signaling pathways. PMID: 24339791
    7. The C57BL/6NJ-Crb1(rd8) mutation and its associated retinal phenotypes were corrected efficiently by TALEN-mediated homology-directed repair. PMID: 24346171
    8. This study demonistrated that the Rd8 mutation in the Crb1 gene of CD11c-eYFP transgenic reporter mice results in abnormal numbers of CD11c-positive cells in the retina. PMID: 23860032
    9. Data show the deletion of Pals1 leads to the disruption of the apical localization of Crb polarity complex proteins Crb1, Crb2 and Crb3 in retinal progenitors and the adult retina. PMID: 22398208
    10. CRB1 mutations lead to early-onset severe loss of vision with thickened, disorganized, nonseeing retina. Impaired peripheral vision can persist in late disease stages. PMID: 21757580
    11. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. PMID: 11744384
    12. During light exposure Crb1 is essential to maintain, but not assemble, adherens junctions between photoreceptors and Muller glia cells and prevents retinal disorganization and dystrophy. PMID: 15316081
    13. RNA interference-induced silencing of the Crb1-interacting-protein Pals1 (protein associated with Lin7; Mpp5) in Muller glial cells resulted in loss of Crb1, Crb2, Mupp1 and Veli3 protein localization and partial loss of Crb3. PMID: 16885194
    14. The extracellular domain of Crb1 positively regulates pituitary tumor transforming gene 1 (Pttg1) transcript levels. PMID: 17234588
    15. We propose that Crb1 is required to regulate number and size of these Muller glia cell villi. The subsequent loss of retinal integrity resulted in neovascularization, in which blood vessels of the choroid protruded into the neural retina. PMID: 17705196

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells.
  • 亞細(xì)胞定位：
    [Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Secreted. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.; [Isoform 3]: Secreted. Cytoplasm. Cell junction, focal adhesion.
  • 蛋白家族：
    Crumbs protein family
  • 組織特異性：
    [Isoform 1]: Expressed in the kidney, lung, stomach and testis. Expressed in the brain. Expressed in the retina of the eye. Expressed in the outer nuclear layer, photoreceptor layer and inner nuclear layer of the retina. Expressed in Mueller cell radial p
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 插插插精品亚洲一区| 无码人妻视频一区二区三区| 脱岳裙子从后面挺进去在线观看| 日韩av在线观看免费| 亚洲已满18点击进入在线观看| 久久天天躁狠狠躁夜夜爽| 久久精品aⅴ无码中文字字幕蜜桃| 久久无码av三级| 亚洲人成无码网www电影麻豆 | 狠狠躁夜夜躁人人爽天天古典 | 日韩精品亚洲色大成网站| 国产成人麻豆亚洲综合精品| 4399理论片午午伦夜理片| 国产精品无码成人午夜电影| 国内大量揄拍人妻在线视频| 日本少妇被黑人xxxxx| 欧美xxxx做受欧美| 中国精品偷拍区偷拍无码| 人人爽久久涩噜噜噜av| 中国少妇内射xxxhd| 亚洲精品亚洲人成在线下载| 国产乱人无码伦av在线a| 久久久久国精品产熟女久色| a 'v片欧美日韩在线| 久久精品青青草原伊人| 久久av一区二区三区| 精品人妻少妇嫩草av无码专区 | 免费的av网站在线观看国产精品| 精品一区二区三区在线播放视频 | 国产98在线 | 免费| 中文字幕人妻无码系列第三区| 国产精品多人p群无码| 18禁区美女免费观看网站| 九九九精品成人免费视频小说 | 狠狠色综合网丁香五月| 伊人久久大香线蕉av最新| 亚洲人成电影在线天堂色| 成年美女黄网站色大免费视频| 久久发布国产伦子伦精品| 小12萝裸体自慰出白浆| 亚洲旡码欧美大片|