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  4. Recombinant Mouse CpG-binding protein (Cxxc1)

Recombinant Mouse CpG-binding protein (Cxxc1)

  • 中文名稱：
    Recombinant Mouse CpG-binding protein(Cxxc1)
  • 貨號：
    CSB-YP871915MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse CpG-binding protein(Cxxc1)
  • 貨號：
    CSB-EP871915MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse CpG-binding protein(Cxxc1)
  • 貨號：
    CSB-EP871915MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse CpG-binding protein(Cxxc1)
  • 貨號：
    CSB-BP871915MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse CpG-binding protein(Cxxc1)
  • 貨號：
    CSB-MP871915MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cxxc1
  • Uniprot No.：
  • 別名：
    Cxxc1; Cgbp; Pccx1CXXC-type zinc finger protein 1; CpG-binding protein; PHD finger and CXXC domain-containing protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-660
  • 氨基酸序列
    MEGDGSDLEP PDAGDDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKCR ERDGSERAGS EPRDEGGGRK RPASDPELQR RAGSGTGVGA MLARGSASPH KSSPQPLVAT PSQHHHQQQQ QQQQQIKRSA RMCGECEACR RTEDCGHCDF CRDMKKFGGP NKIRQKCRLR QCQLRARESY KYFPSSLSPV TPSEALPRPR RPPPTQQQPQ QSQKLGRIRE DEGTVLSSVV KEPPEATATP EPLSDEDLAL DPDLYQDFCA GAFDDHGLPW MSDAEESPFL DPALRKRAVK VKHVKRREKK SEKKKEERYK RHRQKQKHKD KWKHPERADA KDPASLPQCL GPGCVRAAQP GSKYCSDDCG MKLAANRIYE ILPQRIQQWQ QSPCIAEEHG KKLLERIRRE QQSARTRLQE MERRFHELEA IILRAKQQAV REDEENNEND SDDTDLQIFC VSCGHPINPR VALRHMERCY AKYESQTSFG SMYPTRIEGA TRLFCDVYNP QSKTYCKRLQ VLCPEHSRDP KVPADEVCGC PLVRDVFELT GDFCRLPKRQ CNRHYCWEKL RRAEVDLERV RVWYKLDELF EQERNVRTAM TNRAGLLALM LHQTIQHDPL TTDLRSSADR
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that CXXC finger protein 1 (Cfp1) is necessary for hematopoietic stem and multi-potential progenitor cell function and for the developmental potential of differentiating hematopoietic cells. PMID: 25470594
    2. NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A. PMID: 23851690
    3. The results demonstrated that Cfp1 is a specificity factor that integrates multiple signals, including promoter CpG content and gene activity, to regulate genome-wide patterns of H3K4me3. PMID: 22855832
    4. a primary function of non-methylated CpG islands is to genetically influence the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins PMID: 20393567
    5. embryonic stem cells lacking Cfp1 (CXXC1(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 functions to inhibit or restrict the activity of the Setd1A histone H3K4 methyltransferase complex. PMID: 19951360
    6. findings show that CGBP is essential for normal epigenetic modification of the genome by cytosine methylation and for cellular differentiation, consistent with the requirement for CGBP during early mammalian development PMID: 15923607
    7. expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1 PMID: 19433449

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  • 亞細(xì)胞定位：
    Nucleus speckle. Nucleus.
  • 組織特異性：
    Expressed in seminiferous tubules and in both germ cells and Sertoli cells. Highly expressed in spermatogonia, weakly expressed in leptonema and zygonema, and then again high expression in pachynema and diplonema, decreasing to undetectable levels in sper
  • 數(shù)據(jù)庫鏈接：


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