在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Coxsackievirus and adenovirus receptor homolog (Cxadr), partial

Recombinant Mouse Coxsackievirus and adenovirus receptor homolog (Cxadr), partial

  • 中文名稱：
    Recombinant Mouse Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-YP006237MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-EP006237MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-EP006237MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-BP006237MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-MP006237MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cxadr; Car; Coxsackievirus and adenovirus receptor homolog; CAR; mCAR
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
  • 基因功能參考文獻：
    1. In blastocysts, CAR was expressed at the cell contacts within the inner cell mass as well as in the trophectoderm (TE) where CAR was found together with ZO1 at the apical contacts, suggesting that CAR builds up apical TJs in TE and mediates cell adhesion in TE and inner cell mass. CAR was expressed in TE of implanting embryos as well as endometrial epithelium. PMID: 27226313
    2. Coxsackievirus and Adenovirus Receptor and potentially an unidentified factor present in mouse serum might be important mediators of Human adenoviral serotype 5 transduction. PMID: 28381574
    3. Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response PMID: 26076477
    4. the intracellular domain of CAR differentially regulates AdV entry and trafficking. Our study highlights the mechanistic differences that a receptor can have for two viruses from the same family. PMID: 26136571
    5. Conclude that CXADR possesses no direct role in testicular physiology in vivo. PMID: 24625359
    6. with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction. PMID: 22282254
    7. novel modifier of ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia PMID: 24291282
    8. CAR belongs to the increasing list of cell surface molecules that undergo ectodomain shedding and that are substrates for -secretase-mediated RIP. PMID: 24015300
    9. These findings indicate that CAR plays an important role in the initiation of coxsackievirus B virus infections and is closely associated with hepatotropism and age-specific susceptibility. PMID: 23620416
    10. CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions. PMID: 22624044
    11. CAR exerts important functions in the physiology of several organs in vivo PMID: 21674029
    12. Data show for the first time that CAR upregulation in the adult mouse heart induces cardiac inflammation reminiscent of early viral myocarditis. PMID: 21352828
    13. increased CAR expression has a role in inducing cardiomyopathy PMID: 20144615
    14. crystal structure of junctional adhesion molecule-like protein (JAML) and coxsackie and adenovirus receptor; data show how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase to a JAML intracellular sequence motif PMID: 20813955
    15. Adoptive transfer of Tregs protected mice from coxsackievirus B3-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway. PMID: 20530002
    16. Blocking antibodies were found to inhibit neurite extension in retina organ and retinal explant cultures, whereas the application of extracellular CAR domains promoted neurite extension and adhesion to extracellular matrices. PMID: 20181587
    17. Review: Receptor for the group B coxsackieviruses and adenoviruses, CAR PMID: 11479928
    18. Coxsackievirus and adenovirus receptor (CAR) is found in complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX) PMID: 12468544
    19. The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene PMID: 12823902
    20. CAR provides positive survival signals to cardiomyocytes that are essential for normal heart development. PMID: 15864812
    21. CAR is a partner in a protein complex organized at specific subcellular sites by Ligand-of-Numb Protein-X2 PMID: 15979067
    22. During a specific temporal window, CAR expression on cardiomyocytes is essential for normal cardiac development. PMID: 16543498
    23. Attachment of mouse adenovirus type 1 (MAV-1) to Chinese hamster ovary (CHO) cells was not increased by stable transfection with mouse CAR, whereas binding efficiency of Ad2 was 20-fold higher in the mouse CAR-transfectant compared to wild type cells. PMID: 16806202
    24. CAR is an immunoglobulin domain-containing protein that bears homology to cell-adhesion molecules suggesting the possibility that it may participate in organization of the developing olfactory system. PMID: 16841169
    25. Overexpression of CAR may lead to physiological dysfunction by disturbing sarcolemmal integrity (through dystrophin deficiency), impairing sarcolemmal repair (through dysferlin deficiency), and interfering with normal signaling . PMID: 17148677
    26. present work shows that stable and transient expression of CAR in tumor cells reduced lung metastasis in an experimental lung metastasis model; CAR expression likely acts as a metastatic suppressor PMID: 17546646
    27. A function for CAR in testis morphogenesis and in migration of germ cells across the blood-testis barrier during spermatogenesis. PMID: 17690169
    28. Activation of STAT1 protein is an early event in coxsackievirus-induced myocarditis preceding enhanced CAR expression during tissue reorganization. PMID: 18329552
    29. CAR mediates atrioventricular-node function in the murine heart. PMID: 18636119
    30. Systemic delivery of PEGPE-adenovirus complex is an effective tool of adenoviral delivery as it overcomes limitation due to CAR deficiency of target cells while reducing hepatic uptake and enhancing adenoviral gene expression in tumors. PMID: 18779655
    31. Results indicate that CAR is not only relevant for virus uptake and cardiac remodeling but also has a previously unknown function in the propagation of excitation from the atrium to the ventricle. PMID: 18794341
    32. it is proposed that adenovirus CAV-2 transport in motor neuron is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis PMID: 19461877
    33. These results demonstrate a critical function for coxsackievirus and adenovirus receptor in the pathogenesis of group B coxsackievirus infection in vivo and in virus tropism for the heart and pancreas. PMID: 19616768
    34. CAR activation dramatically improves fatty liver and ameliorates hyperglycemia. PMID: 19850873
    35. This manuscript demonstrates a unique role for CAR in the AV-node related to localization of connexin 45 to the cell-cell junction. Atrioventricular node block occurs in the absence CAR. PMID: 18636119

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction.; [Isoform 3]: Secreted.
  • 組織特異性：
    Expressed in liver, kidney, heart, lung, and brain. In skeletal muscle is found at the neuromuscular junction. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks.
  • 數據庫鏈接：


主站蜘蛛池模板： 午夜福利午夜福利1000| 国产农村乱对白刺激视频| 国产一区二区三区在线蜜桃| 亚洲精品成人久久电影网| 欧美日韩一本的免费高清视频| 国产制服丝袜欧美在线观看| 色偷偷人人澡人人爽人人模| 欧美精品无码一区二区三区| 亚洲 精品 综合 精品 自拍| 大香线蕉伊人精品超碰| 亚洲综合天堂一区二区三区 | 99久久精品精品6精品精品 | 大香伊蕉在人线免费视频| 真实国产乱子伦对白在线播放| 国产精品门事件av| 成年女人毛片免费观看97| 亚洲综合无码精品一区二区三区| 久久久久人妻精品一区三寸| 国内精品伊人久久久久影院对白| 国产美女被遭高潮免费网站| 国产成年女人毛片80s网站| 成年女人毛片免费视频| 国产成人精品福利网站| 免费人成在线观看成人片| 成人无遮挡裸免费视频在线观看| 老司机在线精品视频播放| 国产乱子伦一区二区三区| 亚洲伊人久久大香线蕉| 把腿张开老子臊烂你多p视频| 久久综合狠狠综合久久激情| 成人伊人精品色xxxx视频| 亚洲日韩精品一区二区三区无码| 中文亚洲无线码49vv| 亚洲欧美第一成人网站7777| 国产精品久久人妻无码网站一区| 熟妇人妻无乱码中文字幕真矢织江| 免费看美女部位隐私网站| 激情国产一区二区三区四区| 综合 欧美 亚洲日本| 四虎国产精品永久免费网址 | 97se狼狼狼狼狼亚洲网|