在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Contactin-associated protein 1 (Cntnap1), partial

Recombinant Mouse Contactin-associated protein 1 (Cntnap1), partial

  • 中文名稱：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 貨號：
    CSB-YP005692MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 貨號：
    CSB-EP005692MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 貨號：
    CSB-EP005692MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 貨號：
    CSB-BP005692MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 貨號：
    CSB-MP005692MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cntnap1
  • Uniprot No.：
  • 別名：
    Cntnap1; Nrxn4Contactin-associated protein 1; Caspr; Caspr1; MHDNIV; NCP1; Neurexin IV; Neurexin-4; Paranodin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
  • 基因功能參考文獻：
    1. E. coli exploits Caspr1 as a host receptor for penetration of the blood-brain barrier, resulting in meningitis PMID: 29895952
    2. In Caspr1 mutants, there was a reduction in conductive properties of peripheral myelinated fibers and neuromuscular junction disintegration. PMID: 28370195
    3. Caspr as a novel key regulator that controls the temporal specification of cell fate in radial glial cells of the developing cerebral cortex through Notch signaling PMID: 26740489
    4. Simultaneous deletion of Caspr and Caspr2 disrupts the internodal organization of Kv1.2. PMID: 25378149
    5. Caspr co-localizes and interacts with APP. Amyloid-beta (Abeta) 40 and Abeta42 generation were also reduced in HEK-APP cells by Caspr overexpression. PMID: 23748076
    6. Caspr labeling was observed through much of the retina, including horizontal, bipolar, amacrine, and ganglion cells. PMID: 21031018
    7. Clustering of Caspr at initial contact sites between OL processes and the axon requires glial expression of NF155 but not of contactin. Expression of membrane proteins along the axolemma is determined by the type of the contacting glial cells. PMID: 19565653
    8. These results suggest that Caspr serves as a "transmembrane scaffold" that stabilizes the Caspr/contactin adhesion complex at the paranodal junction by connecting it to cytoskeletal components within the axon. PMID: 12082082
    9. F3/contactin and caspr/paranodin traffic to the cell surface via a non-conventional pathway PMID: 12972410
    10. Nogo-A interacts in trans with axonal Caspr at CNS paranodes, an interaction that may have a role in modulating axon-glial junction architecture and possibly K(+)-channel localization during development. PMID: 14592966
    11. the Caspr/Cont complex is essential for the formation of axoglial SJ PMID: 17549747
    12. Caspr protein is required for recruitment and retention of KCNQ4 at calyceal synapses in vestibular hair cells. PMID: 19279247
    13. The Caspr gene has been identified in the neurological mutant shambling (shm) mouse and shown to encode the contactin-associated protein, which is a major component of the paranodal junction in myelinated nerves. PMID: 19816196
    14. These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction. PMID: 11395000
    15. Both NCP1 and CGT mutants develop large swellings accompanied by cytoskeletal disorganization and degeneration in the axons of cerebellar Purkinje neurons. PMID: 16551741

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction.
  • 蛋白家族：
    Neurexin family
  • 組織特異性：
    Expressed in brain. In myelinated nerve fibers predominantly found in paranodal axoglial junctions. In the internodal region of myelinated axons in the CNS and the PNS also found as a thin line apposing the inner mesaxon of the myelin sheath. In PNS neuro
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品无码嫩草地址更新| 国产精品无码2021在线观看| 野外被强j到高潮免费观看| 国产成人一区二区三区app| 高潮毛片无遮挡高清免费| 99久久久无码国产精品试看| 两性色午夜视频免费老司机| 成 人 网 站 免费 在线| 人妻无码一区二区三区四区 | 一本一道色欲综合网中文字幕| 日韩精品人涩人| 无码免费h成年动漫在线观看| 丰满少妇69激情啪啪无| 好男人社区神马在线观看www| 全球成人中文在线| 884aa四虎影成人精品| 亚洲国产欧洲综合997久久| 国产成人免费97在线观看| 新版天堂8中文在线最新版官网| 一本久道综合色婷婷五月| 18禁成人网站免费观看| 亚洲看片lutube在线观看| 亚洲 制服丝袜 中文字幕 在线| 农村老熟妇乱子伦视频| 国产精品对白交换视频| 亚洲欧美精品综合在线观看| 啪一啪射一射插一插| 久久久久黑人强伦姧人妻| 日本特黄特黄刺激大片| 亚洲精品国产一区二区在线观看| 国产精品美女久久久久av超清| 日韩超碰人人爽人人做人人添 | 亚洲中文字幕在线观看| 2021国产精品视频网站| 97熟女毛毛多熟妇人妻aⅴ| 国产精品国产亚洲精品看不卡| 亚洲乱亚洲乱少妇无码| 精品四虎国产在免费观看 | 国产成+人+综合+亚洲欧美丁香花 欧美性黑人极品hd另类 | 精品久久久久久无码人妻| 伊人无码一区二区三区|