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  4. Recombinant Mouse Complement decay-accelerating factor, GPI-anchored (Cd55)

Recombinant Mouse Complement decay-accelerating factor, GPI-anchored (Cd55)

  • 中文名稱：
    Recombinant Mouse Complement decay-accelerating factor, GPI-anchored(Cd55)
  • 貨號：
    CSB-YP720250MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Complement decay-accelerating factor, GPI-anchored(Cd55)
  • 貨號：
    CSB-EP720250MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Complement decay-accelerating factor, GPI-anchored(Cd55)
  • 貨號：
    CSB-EP720250MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Complement decay-accelerating factor, GPI-anchored(Cd55)
  • 貨號：
    CSB-BP720250MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Complement decay-accelerating factor, GPI-anchored(Cd55)
  • 貨號：
    CSB-MP720250MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cd55; Cd55a; Daf; Daf1Complement decay-accelerating factor; GPI-anchored; DAF-GPI; CD antigen CD55
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    35-362
  • 氨基酸序列
    DCGPPP DIPNARPILG RHSKFAEQSK VAYSCNNGFK QVPDKSNIVV CLENGQWSSH ETFCEKSCVA PERLSFASLK KEYLNMNFFP VGTIVEYECR PGFRKQPPLP GKATCLEDLV WSPVAQFCKK KSCPNPKDLD NGHINIPTGI LFGSEINFSC NPGYRLVGVS STFCSVTGNT VDWDDEFPVC TEIHCPEPPK INNGIMRGES DSYTYSQVVT YSCDKGFILV GNASIYCTVS KSDVGQWSSP PPRCIEKSKV PTKKPTINVP STGTPSTPQK PTTESVPNPG DQPTPQKPST VKVSATQHVP VTKTTVRHPI RTSTDKGEPN TG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.
  • 基因功能參考文獻：
    1. CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow. PMID: 27929130
    2. regulates self-renewal and cisplatin resistance in endometrioid tumors PMID: 28838952
    3. Results show that definitive endoderm (DE) expressing Daf1 are slowly proliferating and adhesive cells suggesting that Daf1 is a marker of late stage DE. PMID: 27245320
    4. these data show a key role for HIF-1alpha in regulating the expression of CD55 on airway epithelium. PMID: 27494303
    5. CD55 is produced by the synovium and deposited on local collagen fiber meshwork, where it protects against immune complex-mediated arthritis. PMID: 25596646
    6. Fibrosis in Daf1-/- mice was accompanied by high expression of alpha-smooth muscle actin. PMID: 25032961
    7. the downregulation of CD55 expression precedes, and has an important role regarding, the activation of C3 in the occurrence and development of DNP. PMID: 25377281
    8. IFN-gamma-producing NKT cells enhance C5a generation via IL-10-mediated inhibition of CD55 expression on neutrophils, thereby exacerbating sepsis. PMID: 24723363
    9. CD55 downregulates CD97 surface expression on circulating leukocytes by a process that requires physical forces. PMID: 23447688
    10. Trypanosoma cruzi-inoculated DAF-deficient mice provide a useful model for studying T-cell mediated immunity in skeletal muscle tissues. PMID: 22987701
    11. These data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense. PMID: 21984892
    12. DAF suppressed T-cell immunity as a complement regulator in the context of inflammation but did not play an intrinsic role on T cells or antigen-presenting cells PMID: 21652682
    13. These data suggest an intriguing effect of reduced DAF expression on host responses following in vivo mouse cytomegalovirus infection. PMID: 21166665
    14. Murine cytomegalovirus infection augments morbidity and mortality post-allo-bone marrow transplantion by reducing surface DAF expression. PMID: 20840652
    15. DAF1 expression is maintained until differentiation day 12 in ES cell-derived definitive endoderm cells. PMID: 20526042
    16. DAF has a role in conferring ocular immune privilege for successful corneal engraftment PMID: 20055803
    17. These findings demonstrate that the absence of Daf1 exacerbates IFN-gamma-dependent murine mercury-induced autoimmunity (mHgIA), with changes in the profile of expressed cytokines. PMID: 20408894
    18. Decay-accelerating factor control of C3a and C5a generation and prevention of the binding of these activation fragments to the C3a and C5a receptors are critical for the biological response to vascular injury. PMID: 20299685
    19. Insight into a role for CD55 interaction with CD97 in the pathogenesis of rheumatoid arthritis suggest that therapeutic strategies that disrupt CD55/CD97 may be clinically beneficial. PMID: 20131275
    20. dysfunction or down-regulation of CD55 may contribute to autoimmune disease pathogenesis and manifestation PMID: 12213736
    21. Mice that lack DAF are markedly more susceptible to anti-AChR-induced myasthenia gravis. PMID: 12417565
    22. In autoantibody-mediated nephritis, DAF serves as the primary barrier to classical complement pathway-mediated injury. PMID: 14764738
    23. Study of Daf1 gene-targeted mice demonstrates that DAF-dependent C3 convertase control of complement is important in regulating gut homeostasis, and consequently its activity may participate in protecting against inflammatory bowel disease. PMID: 15004190
    24. In a murine model using genetically engineered mice, CD55 plays a key role in preventing the initiation of the complement cascade after renal ischemia reperfusion injury. PMID: 15004194
    25. These studies demonstrate the physiologic role of DAF in preventing humoral rejection in the presence of low levels of natural antibodies PMID: 16421483
    26. CD55 has a role in prostate cancer growth and survival PMID: 16533428
    27. A study evaluating whether H. pylori utilizes DAF as a receptor and the role of DAF within H. pylori-infected gastric mucosa is presented. PMID: 16543227
    28. positive regulator of T cell immunity in Coxackievirus B3 myocariditis PMID: 16817758
    29. DAF(high)-Crry(-/-) erythrocytes were significantly more resistant than either DAF(low)-Crry(-/-), DAF(-/-) -Crry(+/+) or wild-type erythrocytes to classical pathway complement-mediated C3 deposition in vitro PMID: 17015743
    30. Results reveal multiple mechanisms of action for DAF in ameliorating systemic autoimmunity. PMID: 17392165
    31. Daf1 expression is closely associated with CD4+ T cell activation and the accumulation of CD44(high)(activated/memory),CD4+ T cells in both spontaneous and induced systemic autoimmune disease. PMID: 17530719
    32. These results demonstrate that DAF is an important regulator of CD8+ T cell immunity in viral infection and that it fulfills this role by acting as a complement inhibitor to prevent virus-triggered complement activation and C5aR signaling. PMID: 17709533
    33. results indicate that APC-expressed DAF regulates local production/activation of C5a following cognate T cell/APC interactions PMID: 17947652
    34. Novel candidate genes in T1D CD55 and Acadl were identified. PMID: 18178847
    35. CD55 plays an important role in tumorigenesis of breast cancer PMID: 18676748
    36. Local complement activation, regulated by donor DAF expression, exerts control over the strength of the direct alloreactive (CD8-positive) alloimmune repertoire, enhancing its pathogenicity. PMID: 18802060
    37. modulation of complement activation through induction of DAF represents an important component of the cytoprotective effects of HO-1 against vascular injury PMID: 19036700
    38. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. PMID: 19297024
    39. In BALB/c mice, DAF-deficient T cells mounted an immune response to local podocyte-bound heterologous IgG, resulting in clinical and pathological features of human focal and segmental glomerulosclerosis . PMID: 19349693
    40. These data provide further evidence that DAF suppresses autoreactive T cell responses in experimental autoimmune encephalomyelitis. PMID: 19660813
    41. The acceleration of lesion development in the absence of DAF provides confirmation of the proinflammatory and proatherosclerotic potential of complement activation in the Ldlr(-/-) mouse model. PMID: 19729477

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Receptors of complement activation (RCA) family
  • 組織特異性：
    Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node.
  • 數據庫鏈接：


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