在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Complement component receptor 1-like protein (Cr1l), partial

In Stock
  • 中文名稱:
    Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial
  • 貨號:
    CSB-EP717575MO1
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP717575MO1 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cr1l.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP717575MO1 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cr1l.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Cr1l
  • Uniprot No.:
  • 別名:
    Cr1l; Crry; CryComplement component receptor 1-like protein; Complement regulatory protein Crry; Protein p65
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    44.5 kDa
  • 表達區域:
    41-405aa
  • 氨基酸序列
    ELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
  • 基因功能參考文獻:
    1. CRRY role in the retinal epithelium and photoreceptor degeneration PMID: 28348233
    2. this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells. PMID: 24850152
    3. Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines. PMID: 21380996
    4. Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease. PMID: 21151910
    5. Crry is clearly present in the placentas from spontaneous abortions in mice. PMID: 20484840
    6. Crry is the only membrane-bound complement regulator expressed on the basolateral surface of murine renal tubular epithelial cells under in vitro culture conditions. PMID: 20675597
    7. Data show that a single-nucleotide polymorphism in the first short consensus repeat of Sle1c Crry introduced a novel N-linked glycosylation site likely responsible for structural alteration. PMID: 20660348
    8. mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition. PMID: 19740350
    9. Long-term complement blockade with Crry, a C3 convertase inhibitor overexpressed in a transgenic mouse line, reduces renal disease and improves survival in lupus-prone MRL/lpr mice. PMID: 11907125
    10. the role of crry in regulating complement regulation PMID: 11915940
    11. Crry is indispensable for erythrocyte protection from spontaneous complement attack PMID: 11986227
    12. Crry plays a more dominant role than DAF in regulating the alternative pathway of complement C3 activation, whereas DAF and Crry are equally effective in preventing antibody-induced runaway complement activation. PMID: 12393518
    13. X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig) PMID: 12767833
    14. Mice transgenic for murine complement inhibitor Crry are largely protected from developing collagen-induced arthritis. PMID: 12902517
    15. Data demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury. PMID: 12973023
    16. The dual function of Crry as a complement regulatory protein and as a T cell costimulator illustrates the importance of complement regulatory proteins as links between innate and adaptive immunity. PMID: 16301324
    17. Results suggest that altered expression of Crry within the tubular epithelium appears to be a critical factor permitting activation of the alternative pathway of complement after ischemia/reperfusion. PMID: 16444293
    18. both a high level expression and a more potent anti-alternative pathway complement activity of Crry contributed to its indispensable role on murine erythrocytes PMID: 17015743
    19. Our data suggest complement provides some protection of mature oligodendrocytes during cuprizone treatment but may be critical for subsequent remyelination events. PMID: 17674370
    20. DAF and Crry double deficiency led to rapid clearance of platelets from circulation in a complement- and macrophage-dependent manner; redundant role of DAF and Crry in platelet survival PMID: 18524992
    21. Membrane complement regulator Crry helps to maintain homeostasis of the complement alternative pathway (AP) and demonstrates that Crry-deficient mice can be rescued on a partial as well as on a complete factor B- or C3-deficient maternal background. PMID: 18684964
    22. Pak1 is an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases. PMID: 19124833
    23. Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. PMID: 19136662
    24. Crry and CD59 are critical in protecting Treg cells from complement mediated injuries. PMID: 19281793

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Receptors of complement activation (RCA) family
  • 組織特異性:
    Ubiquitously expressed (at protein level).
  • 數據庫鏈接:

    KEGG: mmu:12946

    UniGene: Mm.301652



主站蜘蛛池模板: 明星性猛交ⅹxxx乱大交| 日本xxxx少妇高清hd| 亚洲一区二区三区四区五区六区| 2018国产大陆天天弄| 日日橹狠狠爱欧美超碰| 日本又色又爽又黄的视频免| 国产精品 亚洲一区二区三区| 一本色道久久88精品综合| 日韩免费视频| 日本特黄特色特爽大片| 蜜桃日本免费观看mv| 男女边吃奶边做边爱视频 | 国产精品无码人妻一区二区在线 | 国产无套护士在线观看| 国产午夜精品一二区理论影院| 少妇愉情理伦片bd| 无码av波多野结衣久久| 国产真实伦在线观看视频 | 成人免费毛片内射美女-百度| av色综合久久天堂av色综合在| 国产成人亚洲精品无码电影| 国产亚洲精品一区二三区| a亚洲va欧美va国产综合| 狂野欧美性猛xxxx乱大交| 国产白丝精品爽爽久久蜜臀| 骚动漫十八禁在线观看| 久久99精品久久久大学生| 性大毛片视频| 天天摸天天做天天爽天天弄| 国产老熟女狂叫对白| 日本三级吃奶头添泬无码苍井空| 7777精品久久久大香线蕉| 人人妻碰人人免费| 五十路熟女丰满大屁股| 国产亚洲精品a在线无码| 国产成人精品福利一区二区三区| 最美女人体内射精一区二区 | 99热成人精品热久久| 精品国产三级在线观看| 人妻少妇久久中文字幕456| 中文字幕v亚洲日本在线电影|