在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Class E basic helix-loop-helix protein 22 (Bhlhe22)

Recombinant Mouse Class E basic helix-loop-helix protein 22 (Bhlhe22)

  • 中文名稱：
    Recombinant Mouse Class E basic helix-loop-helix protein 22(Bhlhe22)
  • 貨號：
    CSB-YP806494MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Class E basic helix-loop-helix protein 22(Bhlhe22)
  • 貨號：
    CSB-EP806494MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Class E basic helix-loop-helix protein 22(Bhlhe22)
  • 貨號：
    CSB-EP806494MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Class E basic helix-loop-helix protein 22(Bhlhe22)
  • 貨號：
    CSB-BP806494MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Class E basic helix-loop-helix protein 22(Bhlhe22)
  • 貨號：
    CSB-MP806494MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Bhlhe22
  • Uniprot No.：
  • 別名：
    Bhlhe22; Bhlhb5Class E basic helix-loop-helix protein 22; bHLHe22; Class B basic helix-loop-helix protein 5; bHLHb5; Protein BETA3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-355
  • 氨基酸序列
    MERGLHLGAA AASEDDLFLH KSLGTSAAKR LEAAFRSTPP GMDLSLAPPT RERPASSSSP LGCFEPADPE GAGLRLPPPG GGGGASGGGG GVSVPGLLVG SAGVGGEPSL SSLPAGAALC LKYGESAGRG SVAESSGGEQ SPDDDSDGLC ELVLRAGGPD PRASPRAGGG SAKVAEGCSN AHLHGGSGLP PGGPTSGGGS GGGGGGSSKK SKEQKALRLN INARERRRMH DLNDALDELR AVIPYAHSPS VRKLSKIATL LLAKNYILMQ AQALEEMRRL VAYLNQGQAI SAASLPSSAA AAAAAAALHP ALGAYEQAAG YPFSAGLPPA ASCPEKCALF NSVSSSLCKQ CTEKP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA. In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.
  • 基因功能參考文獻：
    1. Bhlhb5 is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus during development. Mice lacking Bhlhb5 had a diminished number of neurons. A Bhlhb5::flpo allele also genetically labels numerous other regions of the nervous system processing sensory input, including the dorsal horn, the retina, and the nucleus of the lateral olfactory tract. PMID: 27151208
    2. hypothesis that neuropathic itch in BHLHB5-deficient animals can be treated by restoring inhibitory controls through spinal cord transplantation and integration of precursors of inhibitory interneurons derived from embryonic medial ganglionic eminence PMID: 25003193
    3. Bhlhb5 is broadly expressed throughout retinogenesis, and is required for the subtype development of amacrine and bipolar cells. PMID: 24123365
    4. These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11. PMID: 22284184
    5. Atonal-related transcription factor Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritis, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch. PMID: 20346763
    6. BETA3 function is linked to the establishment rather than the initiation of neuronal fates PMID: 12175497
    7. Mouse Bhlhb5 can strongly repress a human PAX6 promoter. A single exon encodes a 355-amino-acid bHLH protein. PMID: 12213201
    8. Localization of Bhlhb5 mRNA expression in the central nervous system and sensory organs of the mouse embryo. PMID: 14643684
    9. The results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes. PMID: 17092954
    10. These results show Bhlhb5's function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. PMID: 18957218

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Brain-specific, with the highest expression in the cerebellum.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 欧美另类videossexo高潮| 无码专区丰满人妻斩六十路| 天天躁人人躁人人躁狂躁| 五月av综合av国产av| 毛片tv网站无套内射tv网站| 国产亚洲日韩在线aaaa| 国产av一二三无码影片| 丰满少妇被猛烈进入无码| 亚洲国产成人片在线观看无码 | 国产精品99爱免费视频| 性欧美欧美巨大69| 尤物yw193无码点击进入| 香蕉久久av一区二区三区app| 影音先锋啪啪av资源网站| 国产成人精品视频ⅴa片软件竹菊 免费精品99久久国产综合精品 | 久久青青草原国产精品最新片| 精品国产高清毛片a片看| 黄网在线观看免费网站| 中文字幕乱码无码人妻系列蜜桃| 亚洲国产成人精品无码一区二区| av无码免费岛国动作片不卡| 天天摸天天碰天天添| 色婷婷五月综合久久| 国产亚洲精品自在久久蜜tv| 草草久久久无码国产专区| 色狠狠色噜噜av天堂一区| 最近中文字幕免费mv在线 | 亚洲精品成a人在线观看| 亚洲日韩av一区二区三区中文| 国产精品无码久久av不卡| 国产大学生粉嫩无套流白浆| 国产精品露脸国语对白| 久久av无码aⅴ高潮av喷吹| 把腿张开老子臊烂你多p视频| 国产精品久久久久久超碰| 国产亚洲情侣一区二区无| 中文字幕av伊人av无码av狼人| 极品美女扒开粉嫩小泬| 欧美丰满大乳大屁股流白浆| 亚洲精品无码久久久久yw| 在线观看国产精品普通话对白精品|