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  4. Recombinant Mouse Chromosome-associated kinesin KIF4 (Kif4), partial

Recombinant Mouse Chromosome-associated kinesin KIF4 (Kif4), partial

  • 中文名稱：
    小鼠Kif4重組蛋白
  • 貨號(hào)：
    CSB-YP329234MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kif4重組蛋白
  • 貨號(hào)：
    CSB-EP329234MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kif4重組蛋白
  • 貨號(hào)：
    CSB-EP329234MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kif4重組蛋白
  • 貨號(hào)：
    CSB-BP329234MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kif4重組蛋白
  • 貨號(hào)：
    CSB-MP329234MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kif4
  • Uniprot No.：
  • 別名：
    Kif4; Kif4a; Kns4Chromosome-associated kinesin KIF4; Chromokinesin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Required for mitotic chromosomal positioning and bipolar spindle stabilization.
  • 基因功能參考文獻(xiàn)：
    1. KIF4 was first found in neuron, then in chromatin and later in cytoplasm. It is expressed in various types of cells including cancer cells and germ cells. KIF4 also showed dynamic changes throughout the cell cycle. It is abnormally expressed in many cancers. [review] PMID: 30081192
    2. Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age PMID: 28125646
    3. the silencing of Kif4 regulated VRGFR1 mRNA transcription and sVEGFR1 production in monocytes via the PI3K/Akt signaling pathway, which may be one of the mechanisms responsible for these processes. PMID: 28350061
    4. Kif4 is necessary for efficient migration of cells. PMID: 24658398
    5. Closure of the backdoor by ATP binding and hydrolysis stabilizes two mobile regions, switch I and switch II, to generate the phosphate tube from which hydrolyzed phosphate is released. PMID: 23500491
    6. Results suggest that KIF4 controls the activity-dependent survival of postmitotic neurons by regulating PARP-1 activity in brain development. PMID: 16630823
    7. Embryonic stem cells genetically depleted of KIF4 support anchorage-independent growth and form tumors in nude mice. PMID: 16890532
    8. KIF4 is involved in the anterograde trafficking of ribosomal constituents to axons PMID: 19158085

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Chromokinesin subfamily
  • 組織特異性：
    Expressed in pyramidal cells in juvenile hippocampus, granular cells in juvenile cerebellar cortex and in adult spleen.
  • 數(shù)據(jù)庫(kù)鏈接：


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