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  4. Recombinant Mouse Chorion-specific transcription factor GCMb (Gcm2)

Recombinant Mouse Chorion-specific transcription factor GCMb (Gcm2)

  • 中文名稱：
    小鼠Gcm2重組蛋白
  • 貨號：
    CSB-YP009324MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Gcm2重組蛋白
  • 貨號：
    CSB-EP009324MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Gcm2重組蛋白
  • 貨號：
    CSB-EP009324MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Gcm2重組蛋白
  • 貨號：
    CSB-BP009324MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Gcm2重組蛋白
  • 貨號：
    CSB-MP009324MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Gcm2
  • Uniprot No.：
  • 別名：
    Gcm2; GcmbChorion-specific transcription factor GCMb; mGCMb; GCM motif protein 2; Glial cells missing homolog 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-504
  • 氨基酸序列
    MPADSTQDED AVLSYGMKLT WDINDPQMPQ EPTHFDHFRE WPDGYVRFIY SSQEKKAQRH LSGWAMRNTN NHNGHILKKS CLGVVVCARA CALKDGSHLQ LRPAICDKAR LKQQKKACPN CHSPLELVPC RGHSGYPVTN FWRLDGNAIF FQAKGVHDHP RPESKSETEG RRSALKRQMA SFYQPQKRRS EEPEARSTQD IRGHLNSTAA LEPTELFDMT ADTSFPIPGQ PSPSFPNSDV HRVTCDLPTF QGDIILPFQK YPNPSIYFPG PPWGYELASS GVTGSSPYST LYKDSSVVPD DPDWIPLNSL QYNVSSYGSY ERTLDFTARY HSWKPTHGKP SLEEKVDCEQ CQAVPTSPYY NLELPCRYLP VPAAGTQALQ TVITTTVAYQ AYQHPALKHS DSMQEVSSLA SCTYASENLP MPIYPPALDP QEGVIQAASP SGRAPLKVPG DCQAPRPTLD FPQEADPSGT DGADVWDVCL SGVGSVMGYL DRTGQPFSFD NEDF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.
  • 基因功能參考文獻：
    1. results suggest that MafB regulates later steps of parathyroid development, that is, separation from the thymus and migration toward the thyroid. MafB also regulates the expression of PTH in cooperation with Gcm2 PMID: 21713993
    2. Gcm2 (glial cells missing 2) are involved in the epigenetic regulation of Hes5 transcription by DNA demethylation independently of DNA replication. PMID: 21765423
    3. role of Shh signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium PMID: 21349263
    4. GCM domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain. PMID: 12297286
    5. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. PMID: 17382312

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：


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