在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Chloride channel protein 1 (Clcn1), partial

Recombinant Mouse Chloride channel protein 1 (Clcn1), partial

  • 中文名稱：
    Recombinant Mouse Chloride channel protein 1(Clcn1) ,partial
  • 貨號：
    CSB-YP717540MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Chloride channel protein 1(Clcn1) ,partial
  • 貨號：
    CSB-EP717540MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Chloride channel protein 1(Clcn1) ,partial
  • 貨號：
    CSB-EP717540MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Chloride channel protein 1(Clcn1) ,partial
  • 貨號：
    CSB-BP717540MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Chloride channel protein 1(Clcn1) ,partial
  • 貨號：
    CSB-MP717540MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Clcn1
  • Uniprot No.：
  • 別名：
    Clcn1; Clc1Chloride channel protein 1; ClC-1; Chloride channel protein; skeletal muscle
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Voltage-gated chloride channel. Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction.
  • 基因功能參考文獻：
    1. Data show that Muscleblind-like 1 (Mbnl1) and Muscleblind-Like 3 (Mbnl3) bind skeletal muscle chloride channel CIC-1 (Clc-1) mRNA. PMID: 26501102
    2. Sex hormones at high concentration can rapidly modulate ClC-1 in mouse skeletal muscle fibers in vitro. PMID: 23625574
    3. Myotonia (delayed muscle relaxation) is the most commonly observed symptom in DM1 patients and is caused by aberrant splicing of the skeletal muscle chloride channel (CLCN1) gene PMID: 23828222
    4. Myotonia in adult human skeletal actin transgenic mice may be explained on the basis of a mosaic expression of ClC-1 channels in different fibres and/or on alterations of other conductances. PMID: 23247112
    5. The expression of the muscle chloride channel, ClC-1, in Huntington disease muscle was compromised by improper splicing and a corresponding reduction in total Clcn1 (gene for ClC-1) mRNA. PMID: 23671115
    6. the majority of functional ClC-1 channels localize to the sarcolemma and provide essential insight into the basis of myofiber excitability in normal and diseased skeletal muscle. PMID: 21078869
    7. Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy PMID: 12150905
    8. The A331T mutation causes an unprecedented alteration of ClC-1 gating and reveals novel processes defining transitions between open and closed states in ClC chloride channels PMID: 12196568
    9. A distinct autosomal recessive myotonic mouse in the C57BL/6 background (line B6MT)is reported in which the Clc-1 gene shows polymorphism with no functional consequences. PMID: 12370472
    10. CLC-1 deficiency not only affects muscle relaxation (myotonia) but also modulates diaphragm performance during the contractile phase of the contraction-relaxation cycle PMID: 16959550
    11. alternative splicing is a posttranscriptional mechanism regulating chloride conductance during muscle development, and the chloride channelopathy in a transgenic mouse model of DM1 results from a failure to execute a splicing transition for CLCN1. PMID: 17135300
    12. These results support a molecular mechanism for myotonia in myotonic dystrophy type 1 in which a reduction in both the number of functional sarcolemmal ClC-1 and maximal channel open probability. PMID: 17158949
    13. Clc1 expression was dramatically decreased in Znf9+/- mice. PMID: 17335846
    14. genetic CLC-1 chloride channel deficiency in mice not only produces myotonia but also substantially worsens the isotonic contractile performance of diaphragm muscle. PMID: 17483199
    15. These observations indicate that the myotonia and chloride channelopathy observed in DM both result from abnormal alternative splicing of ClC-1 PMID: 18008009

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-1/CLCN1 subfamily
  • 組織特異性：
    Predominantly expressed in skeletal muscles.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产人成视频在线视频| 九九精品99久久久香蕉| 亚洲色欲色欲www在线观看| 国产又粗又猛又大爽又黄| 琪琪电影午夜理论片八戒八戒| 手机看黄av免费网址| av大片在线无码免费| 性欧美vr高清极品| 最新国产乱人伦偷精品免费网站| 亚洲色大成网站www永久麻豆| 少妇爽到呻吟的视频| 精品久久久久久久无码| 国产亚洲日韩欧美另类第八页| 国产乱子伦精品免费女| 亚洲男人的天堂成人www| 揉着我的奶从后面进去视频| 一性一交一口添一摸视频| 久久99久久99小草精品免视看| 亚洲成年轻人电影网站www| 国产精品久久久久aaaa| 野外做受又硬又粗又大视频| 欲求不满邻居的爆乳在线播放| 国产精品青青青高清在线 | 国产成人亚洲综合图区| 亚洲一区在线观看尤物| 亚洲 欧美 偷自乱 图片| 亚洲在av人极品无码| 天天躁夜夜躁狠狠综合2020| 色窝窝无码一区二区三区色欲| 亚洲午夜精品a片久久www慈禧 | 又黄又湿啪啪响18禁| 国产精品日本一区二区不卡视频| 国产农村妇女精品一二区| 特黄做受又大又粗又长大片| 久久精品99久久香蕉国产| 九九九免费观看视频| 国产免费一卡二卡三卡四卡| av性色在线乱叫| 国产女人和拘做受视频免费| 狠狠躁夜夜躁人人爽天天| 久久99久久99久久综合|