在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Checkpoint protein HUS1 (Hus1)

  • 中文名稱:
    小鼠Hus1重組蛋白
  • 貨號:
    CSB-YP804843MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Hus1重組蛋白
  • 貨號:
    CSB-EP804843MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Hus1重組蛋白
  • 貨號:
    CSB-EP804843MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Hus1重組蛋白
  • 貨號:
    CSB-BP804843MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Hus1重組蛋白
  • 貨號:
    CSB-MP804843MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Hus1; Checkpoint protein HUS1; mHUS1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-280
  • 氨基酸序列
    MKFRAKIVDL ACLNHFTRVS NMIAKLAKTC TLRISPEKLN FILCDKLASG GVSMWCELEQ ENFFSEFQME GVSEENNEIY LELTSENLSR ALKTAQNSRA LKIKLTNKHF PCLTVSVELV SSSSSSRIVV HDIPIKVLPR RLWKDLQEPS IPDCDVSICL PALKMMKSVV EKMRNISNQL VIEANLKGEL NLKIETELVC VTTHFKDLEN PLLPSDSVSQ NRHPEDMAKV HIDIKKLLQF LAGQQVTPTK AVCNIVNNRT VHFDLLLEDV SLQYFIPALS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
  • 基因功能參考文獻:
    1. Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity. PMID: 25915840
    2. Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1 PMID: 22575700
    3. HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1. PMID: 23468651
    4. requirement for Hus1 in the survival and proliferation of mammary epithelium PMID: 19918068
    5. Hus1 is required specifically for one of two separable mammalian checkpoint pathways that respond to distinct forms of genome damage during S phase. PMID: 12529385
    6. Hus1-deficient mouse cells had an impaired S checkpoint after exposure to DNA strand break-inducing agents such as camptothecin or ionizing radiation PMID: 14762204
    7. we show a requirement for Rad17 and Hus1 to induce G(2) arrest as well as Vpr-induced phosphorylation of histone 2A variant X (H2AX) and formation of nuclear foci containing H2AX and breast cancer susceptibility protein 1 PMID: 15485898
    8. results indicate that the role of Hus1 affecting the sensitivity of cells to IR-induced killing is independent of nonhomologous end-joining but might be linked to homologous recombination repair PMID: 16278671
    9. Hus1 loss leads to chromosomal instability during DNA replication, triggering increased apoptosis and impaired proliferation through p53-independent mechanisms. PMID: 17215515
    10. identify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro culture, genotoxic stress responses, embryonic development, and adult homeostasis PMID: 17220276

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    HUS1 family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:


主站蜘蛛池模板: 中文无码第3页不卡av| 欧美色综合天天久久综合精品| 久久精品中文騷妇女内射| 国产成人亚洲精品另类动态 | 久久免费视频精品在线| 中日产幕无线码一区| 无码人妻精品一区二区三18禁 | 色噜噜狠狠狠狠色综合久| 无码人妻啪啪一区二区| 狠狠色丁香婷婷综合| 国产精品青青青在线观看| 色偷偷色噜噜狠狠网站年轻人| 精品国产av 无码一区二区三区| 亚洲乱码国产乱码精品精大量| 国内精品久久久久影院中文字幕| 久久久国产精品麻豆a片| 国产精品.xx视频.xxtv| 丰满大爆乳波霸奶| 韩国无码色视频在线观看| 国产精品调教视频一区| 国产精品美女久久久| 中文字幕乱码无码人妻系列蜜桃| 久久久欧美精品激情| 少妇爱做高清免费视频| 国产精品丰臀| 99精品久久久久久久婷婷| 午夜福利视频极品国产83| 天天爽天天爽天天片a| 青青草大香焦在线综合视频| 欧美成人一区二区三区| 男女下面一进一出好爽视频| 中文字幕久久精品波多野结百度| 国产精品特级毛片一区二区三区| 狠狠综合亚洲综合亚洲色| 久久99av无色码人妻蜜| 无套中出丰满人妻无码| 精品久久久久久综合日本| 99视频精品全部免费免费观看| 国产偷窥熟女精品视频| 樱花草在线社区www| 中文乱码字幕高清一区二区|