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  4. Recombinant Mouse Cellular retinoic acid-binding protein 2 (Crabp2)

Recombinant Mouse Cellular retinoic acid-binding protein 2 (Crabp2)

  • 中文名稱：
    Recombinant Mouse Cellular retinoic acid-binding protein 2(Crabp2)
  • 貨號：
    CSB-YP005936MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cellular retinoic acid-binding protein 2(Crabp2)
  • 貨號：
    CSB-EP005936MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cellular retinoic acid-binding protein 2(Crabp2)
  • 貨號：
    CSB-EP005936MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cellular retinoic acid-binding protein 2(Crabp2)
  • 貨號：
    CSB-BP005936MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cellular retinoic acid-binding protein 2(Crabp2)
  • 貨號：
    CSB-MP005936MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Crabp2
  • Uniprot No.：
  • 別名：
    Crabp2; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-138
  • 氨基酸序列
    MPNFSGNWKI IRSENFEEML KALGVNMMMR KIAVAAASKP AVEIKQENDT FYIKTSTTVR TTEINFKIGE EFEEQTVDGR PCKSLVKWES GNKMVCEQRL LKGEGPKTSW SRELTNDGEL ILTMTADDVV CTRVYVRE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
  • 基因功能參考文獻：
    1. The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR. PMID: 25320093
    2. Results show that acetylation status of CRABPII directly influences embryonic stem cell differentiation in response to retinoic acid. PMID: 25155613
    3. CRABP2 controls mRNA stabilization by HuR. PMID: 24687854
    4. all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma PMID: 23833249
    5. CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells. PMID: 23383201
    6. observations emphasize the important role of CRABP-II in regulating the transcriptional activity of RA through RAR, and they demonstrate that repression of this gene is critical for allowing adipogenesis to proceed PMID: 20228061
    7. Localization revealed epithelial-mesenchymal interactions, differentiation differences within the retinoic acid biosynthesis and signaling pathway, and observations on nuclear versus cytoplasmic locations of Crabp2 and RA receptors (alpha, beta, gamma). PMID: 17363914
    8. TIS7 inhibits CRABP II expression during axonal regeneration, thereby modulating retinoic acid signalling. Hence, neurite initiation and branching are regulated by a negative feedback mechanism involving TIS7 and CRABP II. PMID: 18052984

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  • 亞細胞定位：
    Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 組織特異性：
    Embryo and skin of adult mouse.
  • 數據庫鏈接：


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