在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Calsequestrin-1 (Casq1)

Recombinant Mouse Calsequestrin-1 (Casq1)

  • 中文名稱：
    Recombinant Mouse Calsequestrin-1(Casq1)
  • 貨號：
    CSB-YP004556MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calsequestrin-1(Casq1)
  • 貨號：
    CSB-EP004556MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calsequestrin-1(Casq1)
  • 貨號：
    CSB-EP004556MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Calsequestrin-1(Casq1)
  • 貨號：
    CSB-BP004556MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calsequestrin-1(Casq1)
  • 貨號：
    CSB-MP004556MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Casq1
  • Uniprot No.：
  • 別名：
    Casq1Calsequestrin-1; Calmitine; Calsequestrin; skeletal muscle isoform
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    35-405
  • 氨基酸序列
    EDGLDF PEYDGVDRVI NVNAKNYKNV FKKYEVLALL YHEPPEDDKA SQRQFEMEEL ILELAAQVLE DKGVGFGLVD SEKDAAVAKK LGLTEEDSVY VFKGDEVIEY DGEFSADTLV EFLLDVLEDP VELIEGEREL QAFENIEDEI KLIGYFKSKD SEHYKAYEDA AEEFHPYIPF FATFDSKVAK KLTLKLNEID FYEAFMEEPM TIPDKPNSEE EIVSFVEEHR RSTLRKLKPE SMYETWEDDL DGIHIVAFAE EADPDGYEFL ETLKAVAQDN TENPDLSIIW IDPDDFPLLV PYWEKTFDID LSAPQIGVVN VTDADSIWME MDNEEDLPSA DELEDWLEDV LEGEINTEDD DDDDDDDDDD DDDDD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.
  • 基因功能參考文獻：
    1. Authors hypothesize that the protective effect of aerobic training is essentially mediated by a reduction in oxidative stress during exposure of CASQ1-null mice to adverse environmental conditions. PMID: 29849896
    2. These results suggest that common molecular mechanisms underlie malignant hyperthermia (MH) crises and exertional HS in mice.- PMID: 28465322
    3. Calcium entry activated by ablation of both JP45-CASQ1 and JP45-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles. PMID: 27189940
    4. Transient knockdown of annexin A6 and calsequestrin 1 protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001). PMID: 24505100
    5. results support the view that in skeletal muscles, CASQ1 plays a key role in both Ca(2+) homeostasis and terminal cisternae structure PMID: 22049211
    6. The results presented in this paper unmask a differential effect of CASQ1&2 ablation in fast versus slow fibers PMID: 21941434
    7. Calsequestrin not only stores Ca(2+), but also varies its affinity in ways that progressively increase the ability of the store to deliver Ca(2+) as it becomes depleted, a novel feedback mechanism of potentially valuable functional implications. PMID: 20713548
    8. effect of nockdown of CSQ1 in adult mouse skeletal muscle on Store-operated Ca(2+) entry PMID: 20816068
    9. knocking down CSQ2, but not CSQ1, leads to reduced Ca2+ storage and release in C2C12 myotubes PMID: 16595676
    10. CSQ1 is essential for the normal development of the sarcoplasmic reticulum (SR) and its calcium release units and for the storage and release of appropriate amounts of SR Ca(2+). PMID: 17627988
    11. Data report that calsequestrin-1-null mice exhibit increased spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death, and show that CASQ1 deficiency alters proper control of ryanodine receptor function. PMID: 19237502
    12. In dystrophin-deficient mdx mice the calsequestrin is overpression in laryngeal muscles. PMID: 19301368
    13. ablation of CASQ1 results in malignant hyperthermia- and exertional/environmental heat stroke-like lethal episodes PMID: 19417098

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix.
  • 蛋白家族：
    Calsequestrin family
  • 組織特異性：
    Detected in skeletal muscle (at protein level). Detected in skeletal muscle.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲精品久久久口爆吞精| 永久免费毛片在线播放| 国产亚洲日韩欧美另类丝瓜app| 成人无码av一区二区| 日本高清aⅴ毛片免费| 丁香激情综合久久伊人久久| 国产成人亚洲精品狼色在线| 最新国产精品好看的精品| 午夜大片男女免费观看爽爽爽尤物 | 亚洲中文字幕无码卡通动漫野外| 国产午夜永久福利视频在线观看 | 午夜成人理论福利片| 天天摸日日摸爽爽狠狠| 亚洲超碰无码色中文字幕97| 欧美三级a做爰在线观看| 免费无码国产v片在线观看 | 97se狼狼狼狼狼亚洲网| 人人人妻人人人妻人人人| 9l国产精品久久久久尤物| 人妻少妇-嫩草影院| 老湿机香蕉久久久久久| 黄a大片av永久免费| 国产又色又爽无遮挡免费| 亚洲精品无码久久久影院相关影片| 纯爱无遮挡h肉动漫在线播放| 久激情内射婷内射蜜桃| 国产美女嘘嘘嘘嘘嘘| 久青草国产97香蕉在线视频| 美女脱了内裤张开腿让男人桶网站| 妇女性内射冈站hdwww000| 精品一卡2卡三卡4卡乱码精品视频| 草的我好爽视频| 艳妇臀荡乳欲伦69调教视频| 亚洲第一狼人天堂久久| 久久97超碰色中文字幕总站| 髙清国产性猛交xxxand| 久久综合九色综合欧美就去吻| 亚洲a∨无码国产精品久久网| 大地资源网中文第五页| 久久影院九九被窝爽爽| 日本乱妇乱子视频|