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  4. Recombinant Mouse C-Jun-amino-terminal kinase-interacting protein 4 (Spag9), partial

Recombinant Mouse C-Jun-amino-terminal kinase-interacting protein 4 (Spag9), partial

  • 中文名稱：
    小鼠Spag9重組蛋白
  • 貨號：
    CSB-YP691297MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Spag9重組蛋白
  • 貨號：
    CSB-EP691297MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Spag9重組蛋白
  • 貨號：
    CSB-EP691297MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Spag9重組蛋白
  • 貨號：
    CSB-BP691297MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Spag9重組蛋白
  • 貨號：
    CSB-MP691297MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Spag9
  • Uniprot No.：
  • 別名：
    Spag9; Jip4; Jsap2; Kiaa0516; Mapk8ip4; C-Jun-amino-terminal kinase-interacting protein 4; JIP-4; JNK-interacting protein 4; JNK-associated leucine-zipper protein; JLP; JNK/SAPK-associated protein 2; JSAP2; Mitogen-activated protein kinase 8-interacting protein 4; Sperm-associated antigen 9
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.
  • 基因功能參考文獻：
    1. JLP-deficiency impaired T-cell proliferation. PMID: 28521278
    2. data establish JSAP1 and JLP as positive regulators of kinesin-1-dependent axonal transport, which prevents neuronal degeneration. PMID: 25571974
    3. JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport PMID: 26320416
    4. JSAP1 and JLP, which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 localization to the midbody by forming a tripartite complex of JSAP1/JLP, active ARF6, and kinesin-1. PMID: 25130574
    5. JLP in skin basal keratinocytes plays an important role in UVB-induced apoptosis by modulating p38 MAPK signaling pathways. PMID: 24520900
    6. Data indicate a role of a scaffolding protein JLP in the regulation of surface CD40 expression and fine-tuning of dendritic cell (DC) function. PMID: 23182713
    7. A functional role for JLP in the gep oncogene-regulated neoplastic signaling pathway. PMID: 21472140
    8. describe a protein, JLP, which acts as a scaffolding protein to bring mitogen-activated protein kinases and their target transcription factors together for the execution of specific signaling pathways PMID: 12391307
    9. The JIP4 scaffold protein therefore appears to be a new component of the p38 MAP kinase signaling pathway PMID: 15767678
    10. analysis of a novel protein-protein interaction between KLC1 and JLP that involves leucine zipper-like domains PMID: 15987681
    11. Functions as component of multiprotein cell surface complex to promote myogenesis. PMID: 17074887
    12. Ablation of the scaffold protein JLP causes reduced fertility in male mice. PMID: 18574703
    13. Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. PMID: 19056739

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Lysosome membrane.
  • 蛋白家族：
    JIP scaffold family
  • 組織特異性：
    [Isoform 6]: Highly expressed in brain, kidney, liver, heart.
  • 數據庫鏈接：


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