在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse C-C motif chemokine 5 (Ccl5)

Recombinant Mouse C-C motif chemokine 5 (Ccl5)

  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 5(Ccl5)
  • 貨號：
    CSB-YP004800MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 5(Ccl5)
  • 貨號：
    CSB-EP004800MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 5(Ccl5)
  • 貨號：
    CSB-EP004800MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 5(Ccl5)
  • 貨號：
    CSB-BP004800MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 5(Ccl5)
  • 貨號：
    CSB-MP004800MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ccl5; Scya5C-C motif chemokine 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    24-91
  • 氨基酸序列
    SPYGSDT TPCCFAYLSL ALPRAHVKEY FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
  • 基因功能參考文獻：
    1. the results show that Broadleaf Mahonia is a novel effective antiinflammatory herb in vitro and ex vivo, and that CCL5 may be closely associated with Granulomatous lobular mastitispathogenesis PMID: 29138800
    2. miR-155 enhances venous neointima formation through the autocrine and paracrine effects of smooth muscle-like cell-derived RANTES in a nuclear factor kappaB-dependent manner in arteriovenous shunts. PMID: 29477204
    3. Taken together, our data suggest that CCR5 regulates insulin signaling in hypothalamus which contributes to systemic insulin sensitivity and glucose metabolism. PMID: 27898058
    4. identifies the essential role of the chemoattractive cytokine CCL5 for liver disease progression and especially hepatocellular carcinoma development PMID: 28011329
    5. Breast cancer cell CCL5 mediates bone marrow independent angiogenesis via paracrine signaling. PMID: 27863423
    6. Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis. PMID: 29216863
    7. RANTES levels were associated with TMS measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity. PMID: 26733422
    8. study found that the inflammatory chemokine CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN-expressed D6. PMID: 28674178
    9. A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis. PMID: 27576490
    10. This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation. PMID: 26873938
    11. Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4(+) and CD8(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP-intoxicated mice. PMID: 27226559
    12. CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis. PMID: 27337700
    13. RANTES produced by renal tubular cells act as a key chemokine in acute kidney injury and HIF-1alpha regulated LncRNA-PRINS might be involved in RANTES production. PMID: 26725683
    14. Neutralization of circulating RANTES decreased liver neutrophilic infiltration PMID: 26799785
    15. CCL5 signaling through CCR5 may increase platelet counts during physiological stress. PMID: 26647394
    16. An intriguing finding was that S1P induced c-Fos-inhibited CCL5 directly and also indirectly through inhibition of the IFN-beta amplification loop PMID: 26246404
    17. platelet-derived CCL5 is an important link between platelet activation and neutrophil recruitment in acute colitis PMID: 26089223
    18. Nuclear FAK is associated with chromatin and exists in complex with transcription factors and their upstream regulators that control Ccl5 expression. Furthermore, FAK's immuno-modulatory nuclear activities may be specific to cancerous squamous epithelial cells, as normal keratinocytes do not have nuclear FAK. PMID: 26406376
    19. PRDX6 promotes lung tumor development via its mediated and CCL5-associated activation of the JAK2/STAT3 pathway. PMID: 25582888
    20. High levels of CCL5 expression in mouse and human cell lines might accelerate diffuse large Bcell lymphoma formation in diabetes mellitus. PMID: 24938715
    21. IL-17A contributes significantly to the pathogenesis of renal fibrosis by regulating RANTES-mediated inflammatory cell infiltration PMID: 25158055
    22. decreased CCL5 mRNA expression was observed in kidneys of lupus-prone mice with reduced Fli-1 expression. CCL5 protein expression was significantly decreased in endothelial cells transfected with Fli-1-specific small interfering RNA. PMID: 25098295
    23. We evaluated the mRNA expression of angiogenic and migration factors in MSC and found the expression of CCL5 mRNA was higher in AT-MSC than in BM-MSC or DT-MSC. PMID: 24171667
    24. These results show that IL-32gamma effectively promotes migration of activated T cells via CCL5 production in DCs. PMID: 24882804
    25. TLR4, rather than TLR2, regulates wound healing through TGF-beta and CCL5 expression PMID: 24252748
    26. HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways PMID: 24244375
    27. WT1 regulates the expression levels of Cxcl10 and Ccl5 in epicardial cells directly and indirectly through increasing the levels of IRF7. PMID: 23900076
    28. this study identifies a new role for SARM in CCL5 expression in macrophages. PMID: 24711619
    29. we found that IRF1 was essential for IL-1-induced expression of the chemokines CXCL10 and CCL5 PMID: 24464131
    30. CCL5 is a target gene for AhR, and might be associated with the pathology of dioxin exposure. PMID: 23810773
    31. These data provide in vivo evidence supporting the previously suggested role of Ccl5 in bone remodeling. PMID: 23553711
    32. Taken together the data presented strongly suggest that 4T1 mammary tumor cell invasion in vitro is promoted by D1 mesenchymal stem cell secretions, especially the chemokines CCL5 and CCL9. PMID: 23722213
    33. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation. PMID: 23935096
    34. Study uncovers a novel, chemokine-independent activity of the hematopoietically derived CCL5 that promotes mammary tumor progression via generating MDSCs in the bone marrow in cooperation with tumor-derived colony-stimulating factors. PMID: 23266888
    35. Alloreactive memory CD4(+) T cells contribute to increased expression and secretion of RANTES, and to the Tm and other inflammatory cells migration into the graft. PMID: 23498790
    36. Data indicate that enhanced tumorigenesis is dependent on microbiota-induced chemokine CCL5-driven inflammation, which in turn promotes epithelial activation of the IL-6 pathway, leading to cancer formation. PMID: 23696660
    37. Peptide inhibition of CXCL4-CCL5 interactions may represent a viable translational strategy to limit progression of abdominal aortic aneurysms. PMID: 23288157
    38. Attenuated behavioral hypersensitivity in CCL5-deficient mice observed in the current study could be a result of decreased macrophage infiltration, mobilization, and functional ability at injured sites in neuropathic pain. PMID: 22494919
    39. Chinese herbal antidotes A, H and C in combination can significantly inhibit the RANTES expression in serum and renal tissue of MRL/lpr mice. PMID: 21302497
    40. findings show that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta; impaired accumulation was in part attributable to the epigenetic silencing of key T cell-attracting inflammatory chemokine genes in decidual stromal cells PMID: 22679098
    41. Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes. PMID: 22797700
    42. shikonin can effectively enhance anti-tumor potency of a gene-based cancer vaccine via the induction of RANTES expression at the skin immunization site. PMID: 22494696
    43. CCL5 functions within the glioblastoma microenvironment through CCR1 and CCR5 in a redundant manner. PMID: 22425022
    44. IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells. PMID: 22447977
    45. These data confirm CCL5 is an essential factor for optimal pneumococcal adaptive immunity and show CD4(+) T cell responses to PspA(199-246) are largely resistant to CCL5 deficiency. PMID: 22178100
    46. the involvement of CCL5 in the pathogenesis of colorectal carcinoma PMID: 22205974
    47. Data identify the CCL5/CCR5 interaction as a possible novel molecular target for modulation of neovascularization and eventual tissue repair. PMID: 22214846
    48. Interferon alpha/beta control RANTES production during pneumococcal pneumonia in mice. PMID: 22156592
    49. RANTES/CCL5 mediates trafficking and homing of T lymphocytes, monocytes, and other leukocytes, and has been implicated in arterial injury and atherosclerosis. PMID: 21680945
    50. an important role for RANTES in sustaining CD8 T cell responses during a systemic chronic viral infection. PMID: 21814510

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    T-cell and macrophage specific.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 四虎影视永久地址www成人| 性无码一区二区三区在线观看 | 成人网站在线进入爽爽爽| 欧美疯狂性受xxxxx喷水| 曰本极品少妇videossexhd| 日本熟妇美熟bbw| 久久精品无码一区二区三区免费| 伦人伦xxx国产对白| 国产又色又爽又黄好看的视频| 国产免费爽爽视频在线观看| 网禁拗女稀缺资源在线观看| 亚洲天堂男人影院| 国产在线 | 欧洲| 精品久久久无码中文字幕一丶| 内射白嫩少妇超碰| аⅴ天堂中文在线网| 国产午费午夜福利200集| 亚洲精品久久一区二区无卡| 少妇又紧又深又湿又爽视频| 躁躁躁日日躁| 中文天堂最新版在线www| 2021精品亚洲中文字幕| 午夜精品一区二区三区在线观看| 日本老妇人乱xxy| 九色综合九色综合色鬼| 久久不见久久见www电影免费| 精品久久久无码人妻字幂| 久久精品人人槡人妻人| 狠狠躁夜夜躁人人爽天天bl| 日本va在线视频播放| 亚洲精品白浆高清久久久久久| 亚洲综合最新无码专区| 久久精品中文字幕有码| 国产麻豆天美果冻无码视频| 色综合天天视频在线观看| 久久无码中文字幕免费影院| 色婷婷综合缴情综免费观看| 亚洲国产精品特色大片观看完整版 | 99r在线精品视频在线播放| 午夜一区一品日本| 国产精品亚洲片夜色在线|